The Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü]

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dc.contributor.authorÜnal, M.
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorTuncer, Sema
dc.contributor.authorErol, Atilla
dc.contributor.authorAvunduk, M.
dc.contributor.authorÖkesli, S.
dc.date.accessioned2020-03-26T16:46:29Z
dc.date.available2020-03-26T16:46:29Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractExperimental studies indicate that repeated exposure to sevoflurane can be hepatotoxic. It may be either related with direct effect of this anaesthetic agent or with the degradation of sevoflurane by soda lime which is also known to produce toxic products. The aim of this study was to investigate the effects of repeated sevoflurane anaesthesia on liver in neonatal rats with or without soda lime. Twenty seven rats were used in the experiment (15-30 g weight). The rats were randomly divided into three groups (9 each). The rats were placed in a specially prepared transparant plastic box. Group C was the control group. They received 100% O2. In the anaesthesia circle without sodalime sevoflurane in 2.5-2.7 % concentration with O2 (100%) were administered directly in group S, while the same gas mixture was applied through the soda lime in group, SS. Repeated anaesthesia (five times) was applied to the rats for sixty minutes with two days intervals. SGOT, SGPT and ALP levels were measured from the blood samples. Following sacrifice on the day ten, liver tissue samples were examined using light microscopy for histopathological evaluation. SGOT, SGPT and ALP levels were increased especially in group SS. There were only minimal changes in histopathological evaluation of liver from both experimental groups which were not statistically significant. As a result repeated sevoflurane anaesthesia with or without sodalime has minimal effects on liver.en_US
dc.identifier.citationÜnal, M., Reisli, R., Tuncer, S., Erol, A., Avunduk, M., Ökesli, S., (2003). The Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü]. Türk Anesteziyoloji ve Reanimasyon, 31(1), 14-20.
dc.identifier.endpage20en_US
dc.identifier.issn1016-5150en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18662
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÜnal, M.
dc.institutionauthorReisli, Ruhiye
dc.institutionauthorTuncer, Sema
dc.institutionauthorErol, Atilla
dc.institutionauthorAvunduk, M.
dc.institutionauthorÖkesli, S.
dc.language.isotren_US
dc.relation.ispartofTürk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHepatotoxicityen_US
dc.subjectNeonatal Raten_US
dc.subjectSevofluraneen_US
dc.subjectSoda Limeen_US
dc.titleThe Effects of Repeated Sevoflurane Anaesthesia on Neonatal Rat Liver: the Role of Soda Lime [Tekrarlayan Sevofluran Anestezisinin Yavru Rat Karaciğeri Üzerine Etkileri: Sodalaym'in Rolü] en_US
dc.typeArticleen_US

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