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    Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations
    (ECOLE NATIONALE VETERINAIRE TOULOUSE, 2001) Salbacak, A.; Çelik, I.; Karabulut, A. K.; Özkan, Y.; Uysal, I. I.; Çiçekçibaşı, A. E.
    Effects of morphine on the rat lymphoid tissues and adrenal glands were investigated by means of histological, histometrical and enzyme histochemical methods. The experimental animals were treated with 5 mg/kg morphine hydrochloride at daily intervals for 30 days. Morphine treatment caused severe lymphoid cell depletion from spleen, thymus and lymph nodes whereas, ileal Peyer's patches were affected moderately. Both peripheral blood lymphocyte percentage and ANAE-positive lymphocyte frequency in the lymphocyte fraction decreased. The changes in lymphoid organs provide morphological evidence for morphine induced immune suppression. Along with these, observation of the thickening of the adrenal cortex and medulla might show that morphine induced immuno suppression may occur via increased glucocorticoid secretion.
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    Evaluation of the Potential Beneficial Effects of Ostrich Eggshell Combined With Eggshell Membranes in Healing of Cranial Defects in Rabbits
    (Sage Publications Ltd, 2003) Durmuş, Ercan; Çelik, İlhami; Öztürk, A.; Özkan, Y.; Aydın, M. F.
    Potential beneficial effects of outer and inner ostrich eggshell membranes alone and in combination with the shell powder on bone regeneration in cranial defects of 18 rabbits were investigated using radiological, clinical and histological methods. Three 6 mm wide, half-thickness defects were made in the calvarial bones of each rabbit. One defect remained empty as a control; prepared eggshell membranes were extended across the other two defects; and prepared eggshell powder was inserted inside the membrane in one case. Either alone or in combination with eggshell powder, the outer and inner ostrich eggshell membranes produced little adjunctive effect under the conditions and duration of this experiment.