Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ECOLE NATIONALE VETERINAIRE TOULOUSE
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Effects of morphine on the rat lymphoid tissues and adrenal glands were investigated by means of histological, histometrical and enzyme histochemical methods. The experimental animals were treated with 5 mg/kg morphine hydrochloride at daily intervals for 30 days. Morphine treatment caused severe lymphoid cell depletion from spleen, thymus and lymph nodes whereas, ileal Peyer's patches were affected moderately. Both peripheral blood lymphocyte percentage and ANAE-positive lymphocyte frequency in the lymphocyte fraction decreased. The changes in lymphoid organs provide morphological evidence for morphine induced immune suppression. Along with these, observation of the thickening of the adrenal cortex and medulla might show that morphine induced immuno suppression may occur via increased glucocorticoid secretion.
Açıklama
Anahtar Kelimeler
Morphine, Rat, Lymphoid Organs, Adrenal Glands
Kaynak
Revue De Medecine Veterinaire
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
152
Sayı
10
Künye
Salbacak, A., Çelik, I., Karabulut, A. K., Özkan, Y., Uysal, I. I., Çiçekçibaşı, A. E., (2001). Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations. Revue De Medecine Veterinaire, 152(10), 691-698.
