Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations

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dc.contributor.authorSalbacak, A.
dc.contributor.authorÇelik, I.
dc.contributor.authorKarabulut, A. K.
dc.contributor.authorÖzkan, Y.
dc.contributor.authorUysal, I. I.
dc.contributor.authorÇiçekçibaşı, A. E.
dc.date.accessioned2020-03-26T16:37:07Z
dc.date.available2020-03-26T16:37:07Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractEffects of morphine on the rat lymphoid tissues and adrenal glands were investigated by means of histological, histometrical and enzyme histochemical methods. The experimental animals were treated with 5 mg/kg morphine hydrochloride at daily intervals for 30 days. Morphine treatment caused severe lymphoid cell depletion from spleen, thymus and lymph nodes whereas, ileal Peyer's patches were affected moderately. Both peripheral blood lymphocyte percentage and ANAE-positive lymphocyte frequency in the lymphocyte fraction decreased. The changes in lymphoid organs provide morphological evidence for morphine induced immune suppression. Along with these, observation of the thickening of the adrenal cortex and medulla might show that morphine induced immuno suppression may occur via increased glucocorticoid secretion.en_US
dc.identifier.citationSalbacak, A., Çelik, I., Karabulut, A. K., Özkan, Y., Uysal, I. I., Çiçekçibaşı, A. E., (2001). Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations. Revue De Medecine Veterinaire, 152(10), 691-698.
dc.identifier.endpage698en_US
dc.identifier.issn0035-1555en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage691en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17539
dc.identifier.volume152en_US
dc.identifier.wosWOS:000172514700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONALE VETERINAIRE TOULOUSEen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMorphineen_US
dc.subjectRaten_US
dc.subjectLymphoid Organsen_US
dc.subjectAdrenal Glandsen_US
dc.titleEffects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigationsen_US
dc.typeArticleen_US

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