Yazar "Ülgen, Mehmet S." seçeneğine göre listele

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  • Küçük Resim Yok
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    Aneroid sfigmomanometreyle ölçülen brakiyal arter basıncının santral aortik basınçla karşılaştırılması ve farka etki eden faktörler
    (2008) Kayrak, Mehmet; Ülgen, Mehmet S.; Yazıcı, Mehmet; Demir, Kenan; Doğan, Yıldız; Koç, Fatih; Zengin, Kadriye
    Amaç: Aneroid sfigmomanometreyle alınan brakiyal arter kan basıncı (KB) ölçümleri ile çıkan aorttan alınan KB ölçümleri karşılaştırılarak iki ölçüm yöntemi arasındaki sapmaya etki eden temel faktörler araştırıldı. Ça lış ma pla nı: Çalışmaya, rutin koroner anjiyografi işlemine alınan 463 hasta (177 kadın, 286 erkek, ort. yaş 6011) alındı. Tüm hastalarda çıkan aorttan pigtail kateter aracılığıyla yapılan invaziv KB ölçümleriyle eşzamanlı olarak, sağ koldan aneroid sfigmomanometre ile brakiyal arter KB ölçümleri yapıldı. Sistolik ve diyastolik KB değerlerinden, nabız basıncı (NB), fraksiyone NB ve pulsatilite indeksleri hesaplandı. Bul gu lar: Brakiyal sistolik ve diyastolik KB değerleri, çıkan aorttan alınan ölçümlerden sırasıyla -3.110 mmHg ve 3.07.1 mmHg farklılık gösterdi (p0.001). İki yöntemle ölçülen sistolik KB değerleri kadınlar ve erkekler arasında anlamlı farklılık göstermedi; ancak, brakiyal diyastolik KB kadınlarda anlamlı sapma gösterdi (4.8 mmHg, p0.0001). Sfigmomanometre ile yapılan ölçümde diyastolik KB düzeyindeki sapma 60 yaş ve üzerindeki hastalarda daha fazlaydı (sırasıyla 4.5 mmHg ve 1.1 mmHg, p0.0001). Hipertansiflerde sistolik KB için belirlenen sapma, normotansiflerdekinden fazlaydı (-4 mmHg ve -2.0 mmHg, p0.04). Sistolik KB düzeylerindeki sapma, çıkan aorttan ölçülen sistolik KB düzeyiyle birlikte artmaktaydı (p0.0001). Diyabet ve hipertansiyonun birlikte görüldüğü hastalarda, iki yöntem arasındaki sapma sistolik KB için -5.8 mmHg (p0.01), diyastolik KB için 4.2 mmHg (p0.03) bulundu. Beden kütle indeksi ve kol çevresi ile iki yöntem arasındaki sapma ilişkili değildi. So nuç: İki yöntemle elde edilen KB değerleri arasındaki anlamlı farkları etkilediği bulunan temel faktörler (cinsiyet, yaş, KB yüksekliği ve diyabet varlığı) klinik pratikte dikkate alınmalıdır.
  • Küçük Resim
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    Association Between A/C1166 Gene Polymorphism of the Angiotensin II Type 1 Receptor and Biventricular Functions in Patients With Acute Myocardial Infarction
    (Japanese Circulation Society, 2006) Ülgen, Mehmet S.; Öztürk, Önder; Yazıcı, Mehmet; Kayrak, Mehmet; Alan, Sait; Koç, Fatih; Tekes, Selahattin
    Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before. Methods and Results The study group comprised 132 consecutive patients who were admitted to the coronary care unit with their first acute anterior MI. Systolic and diastolic diameters, volumes, inflow properties, ejection fraction and myocardial performance index of both ventricles were measured. AT1R polymorphism was determined using polymerase chain reaction amplification. Based on A/C1166 polymorphism of ATIR, the patients were classified into 3 groups: group 1, A/A (n=91) genotype, group 2 A/C (n=28), and group 3 C/C (n=13) genotype. When the left ventricular and right ventricular echocardiographic functions were compared, all parameters of the 3 groups were found to be similar. No difference was detected in either the genotype distribution or allele frequencies between the patients and the controls for AT1R. Conclusions The results suggest that A/C1166 polymorphism of AT1R did not influence the risk of either acute MI or biventricular function after anterior MI.
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    Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels
    (Japanese Circulation Soc, 2010) Kayrak, Mehmet; Bacaksız, Ahmet; Vatankulu, Mehmet Akif; Ayhan, Selim S.; Taner, Alparslan; Ünlü, Ali; Yazıcı, Mehmet; Ülgen, Mehmet S.
    Background: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR. Methods and Results: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements >= 200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0 +/- 1.4 vs 2.6 +/- 1.1 mu mol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002). Conclusions: Serum ADMA levels might play a role in EBPR to exercise.
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    The Impact of Central Blood Pressure Levels on the Relationship Between Oscillometric and Central Blood Pressure Measurements: A Multicenter Invasive Study
    (WILEY, 2013) Alihanoğlu, Yusuf İzzettin; Kayrak, Mehmet; Ülgen, Mehmet S.; Yazıcı, Mehmet; Yılmaz, Remzi; Demir, Kenan
    The aim of this study was to investigate impact of central blood pressure (BP) levels and sex on the difference between central and upper arm oscillometric BP values. Oscillometric arterial BP measurements of 675 patients were simultaneously compared with values measured from the ascending aorta. The patients were divided into 3 groups according to systolic BP levels. The upper arm oscillometric device overestimated systolic BP (SBP) at low and medium BP levels but it underestimated SBP at high BP level. As for the effect of sex on differences in central and oscillometric BP, SBP was overestimated to a lesser degree in women than in men at low BP levels, but it was more highly underestimated in women than in men at high BP levels. The difference between oscillometric upper arm BP and aortic BP was directly affected by the patient's central BP level. In addition, the difference between central and oscillometric BP was also affected by sex factor.
  • Küçük Resim Yok
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    The relationship between angiotensin-converting enzyme (insertion/deletion) gene polymorphism and left ventricular remodeling in acute myocardial infarction
    (2007) Ülgen, Mehmet S.; Öztürk, Önder; Alan, Sait; Kayrak, Mehmet; Turan, Yaşar; Tekeş, Selahattin; Toprak, Nizamettin
    BACKGROUND: The development of left ventricular remodeling after acute myocardial infarction is a predictor of heart failure and mortality. The genetic influence on cardiac remodeling in the early period after acute myocardial infarction, is however, unclear. The aim ofthis study was to investigate the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and left ventricular remodeling in the early period in patients with anterior myocardial infarction. METHOD: The study population consisted of 142 patients with their first attack of acute anterior myocardial infarction. Echocardiographic examinations were performed within 24 h of the first attack (first evaluation) and on the fifth day of acute myocardial infarction (second evaluation). Left ventricular end systolic and diastolic diameters, left ventricular end systolic and diastolic volumes, ejection fraction, mitral flow velocities (E, A, E/A), deceleration time, isovolumic relaxation time and myocardial performance index were calculated. ACE I/D polymorphism was determined using polymerase chain reaction amplification. RESULTS: On the basis of polymorphism of the ACE gene, the patients were classified into the three groups: group 1, deletion/deletion (n=59) genotype, group 2 insertion/deletion (n=69), and group 3 insertion/insertion (n=14) genotype. When the first and second sets of echocardiographic results of the groups were compared, all parameters were not different among three groups. In group analysis, Left ventricular systolic diameters, left ventricular diastolic diameters, left ventricular end diastolic diameters, left ventricular ejection fraction and myocardial performance index between first and second echocardiographic results were significantly different in deletion/deletion group and only myocardial performance index and left ventricular ejection fraction in insertion/deletion group (P<0.05). CONCLUSIONS: ACE gene polymorphism may influence early cardiac remodeling after acute myocardial infarction. Patients with the deletion/deletion-insertion/deletion genotype may be particularly more sensitive to ACE-I treatment possibly owing to the more prominent role of the renin-angiotensin system. © 2007 Lippincott Williams & Wilkins, Inc.