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    The effect of allergen immunotherapy on serum periostin levels in children with allergic rhinitis
    (BILIMSEL TIP YAYINEVI, 2019) Ucaryilmaz, Hulya; Emsen, Ayca; Dikener, Ahmet Hakan; Akdam, Neriman; Unlu, Ali; Artac, Hasibe
    Objective: Periostin, an extracellular matrix protein, is related to the eosinophilic airway inflammation. There is no specific marker in allergen immunotherapy to evaluate clinical response. We aimed to investigate the serum periostin levels in the children who receive allergen immunotherapy. Materials and Methods: Sixteen patients between 8-18 years (12.7 +/- 2.8 years) with allergic rhinitis and/or asthma due to grass pollen hypersensitivity and 30 healthy subjects (11.7 +/- 2.6 years) were included. Demographic data, eosinophil counts, skin prick tests and the specific IgE levels of the patients are recorded. Symptom scores, visual analog scales, medication scores were determined and the serum periostin levels were measured in the beginning, 4th and 12th months of the allergen immunotherapy. Results: The symptom scores for rhinitis in the 4th month showed significant improvements in all of the patients (p< 0.05). Nine patients with allergic rhinitis accompanied by asthma, showed significant improvements in 12th month symptom score for asthma (p=0.018). A significant correlation was detected between the initial serum periostin levels and the symptom scores for the eye (r=0.668, p=0.005). No significant difference was found in serum periostin levels between the patient and the control groups. There were no significant differences in serum periostin levels in 4th and 12th months compared to the ones in the beginning. Conclusion: In this study, there were no significant differences in serum periostin levels of children during the allergen immunotherapy. The association of serum periostin levels with symptom scores for the eye needs to be confirmed in more children with allergic rhinoconjunctivitis.
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    The Impacts Of Who Regions, Gender, And Age On The Hiv Incidence In The World In Global Public Health By Log-Linear Models For Three-Way Contingency Tabl
    (Selçuk Üniversitesi, 2023 Eylül) Akdam, Neriman; İyit, Neslihan
    Purpose: Human Immunodeficiency Virus (HIV) incidence is defined as the number of new HIV cases at a time period calculated divided by the number of cases at risk of HIV infection. Contingency tables display frequencies for combinations of two or more categorical variables. In this study, it is aimed to investigate the impacts of WHO regions, gender, and age on HIV incidence all over the world in global public health by log-linear models for a three-way contingency table. Method: Log-linear models are constituted for investigating relationships between categorical variables. In this study, log-linear model for three-way contingency table is fitted to the HIV incidence data all over the world according to the World Health Organization (WHO) regions, gender, and age groups taken as the 2019 Global Burden of Disease (GBD) study data from Global Health Data Exchange website. Results: The main effects of age, gender and WHO regions, and also two-way interaction effects between age* gender, age* WHO region and gender* WHO regions; three-way interaction effect between age*gender*WHO regions are found statistically significant at ? ? 0.05 significant level. Conclusion: As a conclusion of this study, age, gender, and WHO regions are determined as the main effects with all interaction effects of these variables on the HIV incidence.
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    Retrospective Evaluation of Serum Zinc Levels in Patients with Protein-Energy Malnutrition
    (Selçuk Üniversitesi, 2023 Haziran) Özen, Hasan; Emiroğlu, Halil Haldun; Emiroğlu, Melike; Akdam, Neriman; Yorulmaz, Alaaddin
    Aim: In this study, we aimed to investigate the frequency of serum zinc deficiency in children with protein-energy malnutrition and to show the relationship between the degree of malnutrition and serum zinc level. Methods: Methods: This retrospective study was conducted at the Pediatric Gastroenterology, Hepatology, and Nutrition clinic in Selçuk University Hospital, and included 506 patients aged between 1 and 18 years who were diagnosed with protein-energy malnutrition according to the Waterlow classification. Results: The prevalence of serum zinc deficiency was 61.1% in patients with protein-energy malnutrition. The mean serum zinc levels of patients aged 1-5 were significantly lower than those of patients aged 5-12 and 12-18. There was no difference between malnutrition degrees calculated according to Waterlow criteria and mean serum zinc levels. Although the relationship between the degree of malnutrition calculated according to the BGA scale and the mean serum zinc level was not statistically significant, the mean decrease in serum zinc levels was remarkable in contrast to the increase in the level of malnutrition. Conclusion: It is important to routinely measure serum zinc levels in patients with PEM and to provide zinc supplementation if deficiency is detected.
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    Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis [Niveles séricos de factor neurotrófico derivado de cerebro en la enuresis]
    (NLM (Medline), 2020) Kurku, Hüseyin; Soran, Mustafa; Yar, Ahmet; Akdam, Neriman; Arslan, Şükrü; Gönen, Murat
    OBJECTIVES: Enuresis is one of the most frequently seen psycho-social problems in childhood, which causes anxiety and stress in the child, thus affecting his/her self-respect and quality of life. The aim of the study was to determine the role of bladder function or psychologic factors or both as factors causing enuresis. METHODS: This study on pediatric patients with primary enuresis included 30 patients with monosymptomatic nocturnal enuresis (MonoNE), 30 patients with polysymptomatic nocturnal enuresis (PolyNE), and 30 healthy controls, making a total of 90 subjects with an age range of 8-18. In all subjects, the levels of serum and urinary Brain-Derived Neurotrophic Factor (BDNF) were measured, in addition to urinary creatinine levels and calculated as BDNF/Cr ng/mg creatinine (BDNF/ Cr). RESULTS: The serum BDNF results of the PolyNE group (0.949±0.587) were significantly lower than those of the control group (1.158±0.587) (p=0.014). The urinary BDNF results of the PolyNE group (1.107±0.360) were significantly higher than those of both the MonoNE (0.657±0.272) and the control (0.670±0.271) groups (p<0.0001). The BDNF/Cr results of the PolyNE group (1.472±0.714) were significantly higher than those of the MonoNE group (0.956±1.017) and the control group (0.931±0.618) (p=0.044 and p=0.032, respectively). CONCLUSIONS: In addition to bladder-specific problems, it is possible for anxiety and psychological stress-induced problems to occur in PolyNE. Therefore, in addition to the increasing number of studies on the bladder in enuresis, further studies on the neurogenic and psychogenic aspects of enuresis should be carried out.OBJETIVOS: La enuresis es uno de los problemas psicosociales más frecuentes en la infancia, que causa ansiedad y estrés a los niños, afectando a su autoestima y calidad de vida. El objetivo de este estudio es la determinación del papel de la función vesical, los factores psicológicos o ambos como factores causales de la enuresis.MÉTODOS: Este estudio en pacientes pediátricos con enuresis incluyó 30 pacientes con enuresis nocturna monosintomática (ENmono), 30 pacientes con enuresis nocturna polisintomática (ENpoli) y 30 controles sanos, sumando un total de 90 individuos con un rango de edad entre 8-18 años. En todos los casos se midieron los niveles séricos y urinarios de factor neurotrófico derivado del cerebro (FNDC), además de los niveles de creatinina urinaria y se hizo el cálculo de FNDC/Cr ng/mg creatinina. RESULTADOS: Los resultados de FNDC sérico en el grupo ENpoli (0,949±0,587) fueron significativamente menores que los del grupo control (1,158±0,587) (p=0,014). Los resultados de FNDC urinario en el grupo de ENpoli (1,107±0,360) fueron significativamente mayores que los de los grupos ENmono (0,657±0,272) y control (0,670±0,271) (p<0,0001). Los resultados de FNDC/Cr el grupo ENpoli (1,472±0,714) eran significativamente mayores que los de los grupos ENMono (0,956±1,017) y control (0,931±0,618) (p=0,044 y p=0,032, respectivamente). CONCLUSIONES: Además de problemas específicos vesicales, es posible que los problemas de ansiedad e inducidos por estrés psicológico ocurran en la ENPoli. Por lo tanto, además del creciente número de estudios sobre la vejiga en enuresis, es necesario desarrollar más estudios sobre los aspectos neurogénicos y psicogénicos de la enuresis.
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    Statistical inference of stress-strength reliability for the exponential power (EP) distribution based on progressive type-II censored samples
    (HACETTEPE UNIV, FAC SCI, 2017) Akdam, Neriman; Kinaci, Ismail; Saracoglu, Bugra
    Suppose that X represents the stress which is applied to a component and Y is strength of this component. Let X and Y have Exponential Power (EP) distribution with (alpha(1), beta(1)) and (alpha(2), beta(2)) parameters, respectively. In this case, stress-strength reliability (SSR) is shown by P = P (X < Y). In this study, the SSR for EP distribution are obtained with numerical methods. Also maximum likelihood estimate (MLE) and approximate bayes estimates by using Lindley approximation method under squared-error loss function for SSR under progressive type-II censoring are obtained. Moreover, performances of these estimators are compared in terms of MSEs by using Monte Carlo simulation. Furthermore coverage probabilities of parametric bootstrap estimates are computed. Finally, real data analysis is presented.