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Öğe The effect of allergen immunotherapy on serum periostin levels in children with allergic rhinitis(BILIMSEL TIP YAYINEVI, 2019) Ucaryilmaz, Hulya; Emsen, Ayca; Dikener, Ahmet Hakan; Akdam, Neriman; Unlu, Ali; Artac, HasibeObjective: Periostin, an extracellular matrix protein, is related to the eosinophilic airway inflammation. There is no specific marker in allergen immunotherapy to evaluate clinical response. We aimed to investigate the serum periostin levels in the children who receive allergen immunotherapy. Materials and Methods: Sixteen patients between 8-18 years (12.7 +/- 2.8 years) with allergic rhinitis and/or asthma due to grass pollen hypersensitivity and 30 healthy subjects (11.7 +/- 2.6 years) were included. Demographic data, eosinophil counts, skin prick tests and the specific IgE levels of the patients are recorded. Symptom scores, visual analog scales, medication scores were determined and the serum periostin levels were measured in the beginning, 4th and 12th months of the allergen immunotherapy. Results: The symptom scores for rhinitis in the 4th month showed significant improvements in all of the patients (p< 0.05). Nine patients with allergic rhinitis accompanied by asthma, showed significant improvements in 12th month symptom score for asthma (p=0.018). A significant correlation was detected between the initial serum periostin levels and the symptom scores for the eye (r=0.668, p=0.005). No significant difference was found in serum periostin levels between the patient and the control groups. There were no significant differences in serum periostin levels in 4th and 12th months compared to the ones in the beginning. Conclusion: In this study, there were no significant differences in serum periostin levels of children during the allergen immunotherapy. The association of serum periostin levels with symptom scores for the eye needs to be confirmed in more children with allergic rhinoconjunctivitis.Öğe The Impacts Of Who Regions, Gender, And Age On The Hiv Incidence In The World In Global Public Health By Log-Linear Models For Three-Way Contingency Tabl(Selçuk Üniversitesi, 2023 Eylül) Akdam, Neriman; İyit, NeslihanPurpose: Human Immunodeficiency Virus (HIV) incidence is defined as the number of new HIV cases at a time period calculated divided by the number of cases at risk of HIV infection. Contingency tables display frequencies for combinations of two or more categorical variables. In this study, it is aimed to investigate the impacts of WHO regions, gender, and age on HIV incidence all over the world in global public health by log-linear models for a three-way contingency table. Method: Log-linear models are constituted for investigating relationships between categorical variables. In this study, log-linear model for three-way contingency table is fitted to the HIV incidence data all over the world according to the World Health Organization (WHO) regions, gender, and age groups taken as the 2019 Global Burden of Disease (GBD) study data from Global Health Data Exchange website. Results: The main effects of age, gender and WHO regions, and also two-way interaction effects between age* gender, age* WHO region and gender* WHO regions; three-way interaction effect between age*gender*WHO regions are found statistically significant at ? ? 0.05 significant level. Conclusion: As a conclusion of this study, age, gender, and WHO regions are determined as the main effects with all interaction effects of these variables on the HIV incidence.Öğe Retrospective Evaluation of Serum Zinc Levels in Patients with Protein-Energy Malnutrition(Selçuk Üniversitesi, 2023 Haziran) Özen, Hasan; Emiroğlu, Halil Haldun; Emiroğlu, Melike; Akdam, Neriman; Yorulmaz, AlaaddinAim: In this study, we aimed to investigate the frequency of serum zinc deficiency in children with protein-energy malnutrition and to show the relationship between the degree of malnutrition and serum zinc level. Methods: Methods: This retrospective study was conducted at the Pediatric Gastroenterology, Hepatology, and Nutrition clinic in Selçuk University Hospital, and included 506 patients aged between 1 and 18 years who were diagnosed with protein-energy malnutrition according to the Waterlow classification. Results: The prevalence of serum zinc deficiency was 61.1% in patients with protein-energy malnutrition. The mean serum zinc levels of patients aged 1-5 were significantly lower than those of patients aged 5-12 and 12-18. There was no difference between malnutrition degrees calculated according to Waterlow criteria and mean serum zinc levels. Although the relationship between the degree of malnutrition calculated according to the BGA scale and the mean serum zinc level was not statistically significant, the mean decrease in serum zinc levels was remarkable in contrast to the increase in the level of malnutrition. Conclusion: It is important to routinely measure serum zinc levels in patients with PEM and to provide zinc supplementation if deficiency is detected.Öğe Statistical inference of stress-strength reliability for the exponential power (EP) distribution based on progressive type-II censored samples(HACETTEPE UNIV, FAC SCI, 2017) Akdam, Neriman; Kinaci, Ismail; Saracoglu, BugraSuppose that X represents the stress which is applied to a component and Y is strength of this component. Let X and Y have Exponential Power (EP) distribution with (alpha(1), beta(1)) and (alpha(2), beta(2)) parameters, respectively. In this case, stress-strength reliability (SSR) is shown by P = P (X < Y). In this study, the SSR for EP distribution are obtained with numerical methods. Also maximum likelihood estimate (MLE) and approximate bayes estimates by using Lindley approximation method under squared-error loss function for SSR under progressive type-II censoring are obtained. Moreover, performances of these estimators are compared in terms of MSEs by using Monte Carlo simulation. Furthermore coverage probabilities of parametric bootstrap estimates are computed. Finally, real data analysis is presented.