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Öğe The clinical value and histopathological correlation of lacrimal scintigraphy in patients with primary Sjogren's syndrome(LIPPINCOTT WILLIAMS & WILKINS, 2012) Erhamamcı, Seval; Karalezli, Aylin; Yılmaz, Sema; Aktaş, AyşePurpose To evaluate the lacrimal gland function in patients with primary Sjogren's syndrome (SS) using lacrimal scintigraphy (LS) and to determine the relationship between clinicopathological stage of primary SS and LS findings. Methods Seventy eyes from 35 patients with primary SS and 20 eyes from 10 healthy age-matched and sex-matched individuals who served as the control group were included in this study. The patients with primary SS were divided into two groups - early stage and advanced stage - according to the labial biopsy scores (23 patients in early stage and 12 in advanced stage). LS, the Schirmer-1 test, determination of break-up time (BUT), Rose bengal ocular surface vital staining and assessment of functional parameters including ocular surface disease index (OSDI) scores were performed for all cases. LS was used to evaluate tear clearance. Lacrimal scintigrams were evaluated for the presence and severity of delayed tear clearance. Delay in clearance was also subclassified according to the severity of delay (mild, moderate, severe and very severe). LS findings and ophthalmological test results of patients in early stage of disease were compared with the results of those in advanced stage and with those of normal individuals. Result The Schirmer-1 test and BUT values of patients in advanced stage of primary SS decreased significantly, whereas the Rose bengal and OSDI values increased significantly when compared with the values of patients in early stage of primary SS and with those of normal individuals (P<0.05 and P<0.001, respectively). Tear clearance of patients in advanced-stage disease was delayed significantly, compared with the tear delay in patients in early stage of disease and that of normal individuals (P<0.001). An inverse correlation existed between tear clearance and both the Schirmer-1 test and BUT value in all patients (P<0.001). However, there was a positive correlation between both the Rose bengal ocular surface staining values and OSDI scores and tear clearance in all cases (P<0.001). LS findings and ophthalmologic test results were significantly different between early-stage and advanced-stage primary SS. Conclusion The results indicate that LS, which is correlated closely with ophthalmological test results, may be a useful method for the assessment of the lacrimal gland function in patients with primary SS. LS findings and ophthalmological tests may be used for determining disease severity in primary SS. Nucl Med Commun 33:689-694 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe The clinical value of dacryoscintigraphy in the evaluation of lacrimal gland function in patients with Primary Sjogren's Syndrome and comparison with histopathologic stage(SPRINGER, 2009) Günel, Seval Erhamamcı; Karalezli, Aylin; Yılmaz, Sema Nur; Aktaş, Ayşe; Akova, Y.[Abstract not Available]Öğe İvriz Köy Enstitüsü(Selçuk Üniversitesi Sosyal Bilimler Enstitüsü, 2006) Aktaş, Ayşe; Kandır, MehmetCumhuriyet Döneminde her alanda oldugu gibi, egitim-ögretim alanında da inkılaplara girisilmistir. Milli Mücadeleyi yürüten kadronun iktidara geçmesi ile egitim-ögretim alanında simdiye kadar geri plana itilmis köy ve köylü hak ettigi ilgiyi görmeye baslamıstır. Köyler yüzyıllardır süren sömürü ve gerilik kaynagı olmaktan çıkarak Türkiye'nin mutlu geleceginin kaynagı haline getirilmistir. Bu amaçla 17 Nisan 1940'da 3803 sayılı yasa ile ?Köy Enstitüleri? açılmıs ve köy çocukları bu kurumlarda laik ve modern bir egitim sisteminin içinde aydın ve özgür düsünceli bireyler olarak yetistirilmislerdir. Günümüzde uygulanmaya çalısılan yaparak yasayarak ögrenme tekniginin mükemmel bir biçimde uygulandıgı bu kurumlarda köy çocukları yeni fikirlere açık kendi kültürü ile batının yeniliklerini sentezleyebilen hem teknik açıdan bilgili hem de kültürel açıdan donanımlı Cumhuriyete sahip çıkan çagdas ve yenilikçi bireyler olarak yetisiyorlardı. Kurulus sekilleri amaçları ve uygulamaları ile egitim tarihimizde orijinal kurumlar olan Köy Enstitüleri siyasi çekismelerin kurbanı olmus; 27 Ocak 1954 tarihinde 6234 sayılı yasa ile ilk Ögretmen Okulu diye ismi degistirilerek resmen Kapatılmıstır. ivriz Köy Enstitüsünün adı da ivriz ilk Ögretmen Okulu olmustur.Öğe Quantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glands(Lippincott Williams & Wilkins, 2010) Erhamamcı Günel, Seval; Yılmaz, Sema; Karalezli, Aylin; Aktaş, AyşePurpose To evaluate quantitative and visual salivary gland scintigraphy in patients with primary Sjogren's syndrome (SS) and to compare the scintigraphic findings with clinicopathological features of the salivary, lacrimal and thyroid glands. Methods Twenty-seven patients with primary SS and 10 healthy age-matched and sex-matched individuals as a control group were included in this study. The diagnosis of SS was made on the basis of the classification criteria of the American-European Consensus Group. The patients with primary SS were divided into two groups as early-stage and advanced-stage according the labial biposy scores (16 early-stage and 11 advanced-stage). After the administration of 370 M Bq Tc-99m pertechnetate, static images were obtained at 20 min and also after lemon stimulation. Functional parameters for the parotid, submandibular, and thyroid glands were calculated. Schirmer-I, tear film break-up time and Rose Bengal tests were evaluated. Result Statistically significant differences existed for the functional parameters of the parotid and submandibular glands between the early-stage and advanced-stage groups. The submandibular glands were more frequently affected than the parotid glands. Asymmetric uptake pattern was more common in the parotid glands during the early-stages of primary SS. When compared with the control group, the thyroid uptake ratio of the early-stage primary SS and advanced-stage group was not significantly different. According to the results of the ophthalmological tests, there was a statistically significant difference between patients with advanced-stage and early-stage disease. There were no significant correlations between functional parameters of salivary gland and any of the ophthalmological tests. Conclusion The results indicate that quantitative salivary gland scintigraphy may be a useful method for evaluating salivary gland dysfunction and also for determining disease severity in primary SS. Asymmetric activity pattern in the parotid glands commonly observed during the early stages of the disease may be a predictor of progression. In addition, the histopathological stage is related not only to the scintigraphic findings of the salivary glands but also to lacrimal gland function in primary SS. However, thyroid uptake seemed to be unaffected in patients with both early-stage and advanced-stage disease.Öğe Quantitative evaluation of salivary gland dysfunction and thyroid uptake in patients with Primary Sjogren's Syndrome using salivary gland scintigraphy and comparison with histopathologic stage(SPRINGER, 2009) Günel, Seval Erhamamcı; Yılmaz, Sema Nur; Aktaş, Ayşe[Abstract not Available]
