Quantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glands
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose To evaluate quantitative and visual salivary gland scintigraphy in patients with primary Sjogren's syndrome (SS) and to compare the scintigraphic findings with clinicopathological features of the salivary, lacrimal and thyroid glands. Methods Twenty-seven patients with primary SS and 10 healthy age-matched and sex-matched individuals as a control group were included in this study. The diagnosis of SS was made on the basis of the classification criteria of the American-European Consensus Group. The patients with primary SS were divided into two groups as early-stage and advanced-stage according the labial biposy scores (16 early-stage and 11 advanced-stage). After the administration of 370 M Bq Tc-99m pertechnetate, static images were obtained at 20 min and also after lemon stimulation. Functional parameters for the parotid, submandibular, and thyroid glands were calculated. Schirmer-I, tear film break-up time and Rose Bengal tests were evaluated. Result Statistically significant differences existed for the functional parameters of the parotid and submandibular glands between the early-stage and advanced-stage groups. The submandibular glands were more frequently affected than the parotid glands. Asymmetric uptake pattern was more common in the parotid glands during the early-stages of primary SS. When compared with the control group, the thyroid uptake ratio of the early-stage primary SS and advanced-stage group was not significantly different. According to the results of the ophthalmological tests, there was a statistically significant difference between patients with advanced-stage and early-stage disease. There were no significant correlations between functional parameters of salivary gland and any of the ophthalmological tests. Conclusion The results indicate that quantitative salivary gland scintigraphy may be a useful method for evaluating salivary gland dysfunction and also for determining disease severity in primary SS. Asymmetric activity pattern in the parotid glands commonly observed during the early stages of the disease may be a predictor of progression. In addition, the histopathological stage is related not only to the scintigraphic findings of the salivary glands but also to lacrimal gland function in primary SS. However, thyroid uptake seemed to be unaffected in patients with both early-stage and advanced-stage disease.
Açıklama
Anahtar Kelimeler
Lacrimal gland, Primary Sjögren's syndrome, Salivary gland scintigraphy, Thyroid disease, Thyroid uptake
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
31
Sayı
7
Künye
Erhamamcı Günel, S., Yılmaz, S., Karalezli, A., Aktaş, A., (2010). Quantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glands. Nuclear Medicine Communications, 31(7), 666-672. Doi: 10.1097/MNM.0b013e328339bdf6
