Quantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glands

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dc.contributor.authorErhamamcı Günel, Seval
dc.contributor.authorYılmaz, Sema
dc.contributor.authorKaralezli, Aylin
dc.contributor.authorAktaş, Ayşe
dc.date.accessioned2020-03-26T18:04:52Z
dc.date.available2020-03-26T18:04:52Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose To evaluate quantitative and visual salivary gland scintigraphy in patients with primary Sjogren's syndrome (SS) and to compare the scintigraphic findings with clinicopathological features of the salivary, lacrimal and thyroid glands. Methods Twenty-seven patients with primary SS and 10 healthy age-matched and sex-matched individuals as a control group were included in this study. The diagnosis of SS was made on the basis of the classification criteria of the American-European Consensus Group. The patients with primary SS were divided into two groups as early-stage and advanced-stage according the labial biposy scores (16 early-stage and 11 advanced-stage). After the administration of 370 M Bq Tc-99m pertechnetate, static images were obtained at 20 min and also after lemon stimulation. Functional parameters for the parotid, submandibular, and thyroid glands were calculated. Schirmer-I, tear film break-up time and Rose Bengal tests were evaluated. Result Statistically significant differences existed for the functional parameters of the parotid and submandibular glands between the early-stage and advanced-stage groups. The submandibular glands were more frequently affected than the parotid glands. Asymmetric uptake pattern was more common in the parotid glands during the early-stages of primary SS. When compared with the control group, the thyroid uptake ratio of the early-stage primary SS and advanced-stage group was not significantly different. According to the results of the ophthalmological tests, there was a statistically significant difference between patients with advanced-stage and early-stage disease. There were no significant correlations between functional parameters of salivary gland and any of the ophthalmological tests. Conclusion The results indicate that quantitative salivary gland scintigraphy may be a useful method for evaluating salivary gland dysfunction and also for determining disease severity in primary SS. Asymmetric activity pattern in the parotid glands commonly observed during the early stages of the disease may be a predictor of progression. In addition, the histopathological stage is related not only to the scintigraphic findings of the salivary glands but also to lacrimal gland function in primary SS. However, thyroid uptake seemed to be unaffected in patients with both early-stage and advanced-stage disease.en_US
dc.identifier.citationErhamamcı Günel, S., Yılmaz, S., Karalezli, A., Aktaş, A., (2010). Quantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glands. Nuclear Medicine Communications, 31(7), 666-672. Doi: 10.1097/MNM.0b013e328339bdf6
dc.identifier.doi10.1097/MNM.0b013e328339bdf6en_US
dc.identifier.endpage672en_US
dc.identifier.issn0143-3636en_US
dc.identifier.issue7en_US
dc.identifier.pmid20545046en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage666en_US
dc.identifier.urihttps://dx.doi.org/10.1097/MNM.0b013e328339bdf6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25197
dc.identifier.volume31en_US
dc.identifier.wosWOS:000279152000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Sema
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLacrimal glanden_US
dc.subjectPrimary Sjögren's syndromeen_US
dc.subjectSalivary gland scintigraphyen_US
dc.subjectThyroid diseaseen_US
dc.subjectThyroid uptakeen_US
dc.titleQuantitative and Visual Evaluation of Salivary and Thyroid Glands in Patients with Primary Sjogren's Syndrome Using Salivary Gland Scintigraphy: Relationship with Clinicopathological Features of Salivary, Lacrimal and Thyroid Glandsen_US
dc.typeArticleen_US

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