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Öğe Effect on body weight of botilinum type-A toxin injection into submandibular salivary glands: An experimental study in the rabbit model(2013) Sahin M.; Erenoglu B.; Yilmaz H.; Esen H.; Tolu A.; Acar F.; Alptekin H.Background: In this study, we investigated the effects of Botulinum type A toxin (Btx-A) injection into salivary glands on body weight at rabbits. Material and Methods: Forty five rabbits were used in this study, and were divided into three groups of 15 rabbits each, as follows: Group I: Control group , Group II: Btx-A was injected with a dosage of 50 IU into left submandibular gland., Group III: Btx-A was injected with a dosage of 50 IU into each of submandibular glands. The rabbits were weighed monthly. At the end of the 6 months, all animals were sacrificed. Small intestine and submandibular salivary glands were excised. The tissue sections was stained with hematoxylin-eosin and immunostained with primary antibodies for epidermal growth factor receptor (EGFR). The length of villi was measured, and the immunostained cells were counted. Results: Body weights measurement showed an increase of 65.2 % over the initial weight in group I, a decrease of 12.1 % in group II and a decrease of 30.6 % in group III (P<0.001). The villi length was 893±63 ? in group I, 712±30 ? in group II and 621±41 ? in group III (P<0.001). The mean immunostained cells count of submandibular glands was 527±90.7 in group I, 267.8±71.1 in group II and 260.2±76.4 in group III (P<0.001). The mean immunostained cells count of intestinal villi was 906.2±45.7 in group I, 786.4±75.6 in group II and 658±84.3 in group III (P<0.001). Conclusion: In this experimental study, Btx-A injection into submandibular salivary glands lead to intestinal villi atrophy and weight loss in rabbit model.Öğe The effects of chrysin in an experimental model of acute pancreatitis(Edizioni Luigi Pozzi, 2020) Alptekin H.; Calisir A.; Özturk B.; Ugurlu C.; Yormaz S.; Ece I.PURPOSE: This experimental study was conducted to evaluate the possible effects of orally administered chrysin on acute pancreatitis. MATERIAL AND METHOD: Twenty four rats were procured. The animals were randomly divided into four groups. In Group I, only vehicle solution (5% dimethylsulfoksid) was administered, and in Group II, chrysin dissolved in the vehicle solution was administered for six days. In Group III and Group IV cerulein was administered to induce acute pancreatitis. In Group III, only vehicle solution was administered, and in Group IV, chrysin dissolved in the vehicle solution was administered orally for six days. Blood samples were analyzed and the pancreatic tissue specimens were evaluated for histopathological examination. RESULTS: Group III and Group IV, exhibited markedly higher levels of serum WBC, amylase, and lipase, compared with Groups I and II. In the pancreatitis induced groups, CRP and TOS values were found to be significantly higher. In Group II and Group IV, TAS values were significantly higher. The highest calculated OSI values were observed in Group III. Group IV OSI values were significantly lower than those in Group III and even in Group I. Noticeable histopathological changes were identified in the pancreatitis induced Groups III and IV. Compared with Group III, the extent and severity of pancreatic injuries were markedly lower in Group IV. CONCLUSION: Chrysin application reduced oxidative stress and histopathological parameters. The present study shows that chrysin can be used to treat pancreatic diseases. © 2020, Edizioni Luigi Pozzi. All rights reserved.Öğe Gallbladder paraganglioma: computed tomography and magnetic resonance imaging findings(2014) Koplay M.; Sivri M.; Alptekin H.; Erdoğan H.; Nayman A.Paragangliomas are benign tumors that can be association with sympathetic and parasympathetic nerves. More rarely, they can be located in the gallbladder. In this paper, we describe the appearance of an unusual case of paraganglioma in the gallbladder.Öğe Incidence of listeria monocytogenes infection in pregnant women with preterm labor and premature rupture of membranes [Erken membran rüptürü ve erken do?um tehditi olan gebelerde listeria monocytogenes i?nsidansi](2004) Alptekin H.; Gezginç K.; Çelik Ç.; Acar A.; Akyürek C.OBJECTIVE: To investigate the incidence of Listeria monocytogenes infection in pregnant women with premature rupture of membranes and preterm labor. STUDY DESIGN: We chose 77 pregnant women who were between 28th to 37th weeks of gestation as the study group. Within this group, 34 patients had premature rupture of membranes and 43 had preterm labor. Forty healthy pregnant women were served as the control group to a total of 117 women to participate in the study. To detect Listeria monocytogenes infection, we used bacterial cultures and serological tests. RESULT(s): Listeria monocytogenes was diagnosed in a patient with premature labor and Listeria innocua was found in a patient with premature rupture of membranes. In total, listeriosis was detected in 2 (2.5%) patients in the study group, not statistically significant in comparison to the control group. Listeria agglutination type 4bH, 4bO, IO and IH serotypes were examined in the study group. An antibody titer of 1/160 or above was accepted as positive. In 8 patients (10.3%), positive antibody titers were detected for type 4bO and type IO, but their cultures were negative for Listeria. One out of 8 patients has premature labor, and the other 7 patients had premature rupture of membranes. An antibody titer of 1/160 or above against these four serotypes was not detected in the control group. The difference between the study and the control groups was significant in terms of antibody titers of 1/160 or above (p<0.05). CONCLUSION(s): Listeriosis is a rare preventable cause of prenatal mortality. Maternal listeriosis may causes premature birth, premature rupture of membranes and congenital infection of the newborn. In pregnant women with premature labor or premature rupture of membranes, Listeria monocytogenes should be thought as one possible etiologic factor and the infection should be treated if diagnosis is established.Öğe A New Approach to the Complicated Liver Hydatid Cyst--Laparoscopic Roux-en-Y Cystojejunostomy(2015) Yilmaz H.; Sahin M.; Ece I.; Yormaz S.; Alptekin H.Surgery is still the gold standard in the treatment of hepatic hydatid disease. One of the major problems associated with hydatid cyst surgery is biliary fistula. In this report, we aimed to describe a laparoscopic internal drainage method for the treatment of complicated hepatic hydatid cyst in order to prevent long-term biliary fistulas. A 44-year-old female was referred to our clinic with the complaints of flank pain. On computerized tomography of the abdomen, an 8-cm hydatid cyst was detected on the right lob of the liver. Laparoscopic exploration demonstrated a cysto-biliary communication, and laparoscopic cystojejunostomy was performed to prevent long-term bile leakage. The patient was discharged on postoperative day 5 without any problems. In 45th days, nearly complete obliteration of the cavity was observed. Laparoscopic cystojejunostomy can be an effective and safe surgical approach for the treatment of complicated hepatic hydatid cysts.Öğe Preperitoneal mesh placement via internal ring for inguinal hernias: A cost-effective alternative to memory-ring patch(2012) Alptekin H.Background. Groin hernia repair is one of the most frequent procedure in general surgery. Many different techniques of inguinal hernia repair have been described. The successful results of transinguinal preperitoneal (TIPP) repair technique using a memory ring patch have been reported. We have prefered monofilament polypropylene flat mesh instead of memory ring patch which has higher cost to perform TIPP repair technique. The purpose of this retrospective study was to evaluate our primary results more than 3 years after surgery. Methods. This study included consecutive adult patients who were treated with surgery for inguinal hernia by the same surgeon using the same technique between February 2007 and February 2008. A retrospective review of a prospectively maintained databese was performed. Data were reviewed for all patients undergoing TIPP hernia repair. Results. Thirty-three patients (31 men and 2 women) with a mean age of 48.4 years (range 19-67 years) underwent anterior transinguinal preperitoneal mesh hernioplasty. The mean operation time was 26 min (range 17-38 min). The mean follow-up was more than 36 months in all patients (range 37-46 months). There were no recurrences during follow-up. One patient (3%) described chronic groin pain. Conclusion. Groin hernias are a significant health problem and economic burden for developing countries because of high cost of surgery and loss of workforce. TIPP repair technique can be performed using the monofilament polypropylene flat mesh with acceptable long term complication rate. The use of the monofilament polypropylene flat mesh can be feasible and cost effective alternative to memory ring patch, when performing TIPP technique.Öğe Treatment of staple line leaks after laparoscopic sleeve gastrectomy with self-expandable metalic stents [Laparoskopik sleeve gastrektomi sonrası stapler hattı kaçaklarının genişleyebilen metalik stentler ile tedavisi](Turkiye Klinikleri, 2016) Ece İ.; Yilmaz H.; Alptekin H.; Acar F.; Yormaz S.; Çolak B.; Şahin M.Objective: Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric procedure on weight loss and obesity-related comorbidities. The most important complication of LSG is the staple line leaks (SLL). This study aims to report the SLL rate and its management with self-expandable stent in a series of 422 LSGs. Material and Methods: A total of 422 patients underwent LSG from January 2010 to June 2015. A retrospective study was performed to the patients who were diagnosed as staple line leak at department of obesity surgery of a university hospital. The gastric resection was started from the antrum with a distance of 4-6 cm to the pilorus, by a 60mm staples. A 36F bougie was used to calibrate the gastric tube. The staple line was routinely reinforced with running sutures. The patients who developed SLL were treated endoscopically with self-expandable metalic stent (SEMS) placement. Results: The mean age of patients were 41.8 (29-55) years, and female/male ratio was 7/5. Mean body mass index of 44.1 kg/m2 in patients, one of the cases has a gastric banding history. SLL rate was 12/422 (2.8%). Leak area was near the gastroesophageal junction in all cases. SLL was treated with self-expandable metalic stents. All patients were received medical support, including parenteral nutrition and antibiotics. The stent treatment modalities were successful in all cases. Conclusion: SLL was the most common complication of LSG accounting for half of the overall complications. Self-expandable stents combined with antibiotics and parenteral nutrition are effective for SLL and should be proposed as first-line treatment in stable patients. © 2016 by Türkiye Klinikleri.Öğe The use of ankaferd might lead to wound dehiscence in midline laparotomy incision(2011) Alptekin H.; Yilmaz H.; Erdem S.; Esen H.; Kurban S.; Sahin M.Background: Ankaferd Blood Stopper® offered as a hemostatic agent is a standardized herbal extract obtained from five different plants. The effects of ABS on laparotomy incision are unknown. This study was designed to assess potential effects on the healing of midline laparotomy in an experimental animal model. Material and Methods: Sixteen male Wistar albino rats were randomized into two groups and subjected to laparotomy. The study group subjected to laparotomy with local application of ABS to the bleeding points in the subcutaneous tissue, muscle and fascia and the control group subjected to laparotomy only. The rats were killed on postoperative day 7. Three types of assessment were performed: wound breaking strength, histopathology, and biochemical analysis. Results: Compared to the control group, rats in the ABS group displayed a lower wound breaking strength (p<0.05) and tissue hydroxyproline content (p<0.05). The use of ABS leads to a significant increase in malondealdehyde levels (p<0.05). Total histopathological score of groups were similar (p>0.05). Conclusion: Topical application of ABS to the subcutaneous tissue, muscle and fascia significantly impairs the wound healing by means of decreasing mechanical strength and tissue HPL levels.