The use of ankaferd might lead to wound dehiscence in midline laparotomy incision
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Ankaferd Blood Stopper® offered as a hemostatic agent is a standardized herbal extract obtained from five different plants. The effects of ABS on laparotomy incision are unknown. This study was designed to assess potential effects on the healing of midline laparotomy in an experimental animal model. Material and Methods: Sixteen male Wistar albino rats were randomized into two groups and subjected to laparotomy. The study group subjected to laparotomy with local application of ABS to the bleeding points in the subcutaneous tissue, muscle and fascia and the control group subjected to laparotomy only. The rats were killed on postoperative day 7. Three types of assessment were performed: wound breaking strength, histopathology, and biochemical analysis. Results: Compared to the control group, rats in the ABS group displayed a lower wound breaking strength (p<0.05) and tissue hydroxyproline content (p<0.05). The use of ABS leads to a significant increase in malondealdehyde levels (p<0.05). Total histopathological score of groups were similar (p>0.05). Conclusion: Topical application of ABS to the subcutaneous tissue, muscle and fascia significantly impairs the wound healing by means of decreasing mechanical strength and tissue HPL levels.
Açıklama
Anahtar Kelimeler
Ankaferd, Midline laparotomy, Wound dehiscence
Kaynak
Surgical Chronicles
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
16
Sayı
3
