The use of ankaferd might lead to wound dehiscence in midline laparotomy incision

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dc.contributor.authorAlptekin, Hüsnü
dc.contributor.authorYılmaz, Hüseyin
dc.contributor.authorErdem, S.
dc.contributor.authorEsen, H.
dc.contributor.authorKurban, S.
dc.contributor.authorŞahin, Mustafa
dc.date.accessioned2020-03-26T18:22:23Z
dc.date.available2020-03-26T18:22:23Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Ankaferd Blood Stopper® offered as a hemostatic agent is a standardized herbal extract obtained from five different plants. The effects of ABS on laparotomy incision are unknown. This study was designed to assess potential effects on the healing of midline laparotomy in an experimental animal model. Material and Methods: Sixteen male Wistar albino rats were randomized into two groups and subjected to laparotomy. The study group subjected to laparotomy with local application of ABS to the bleeding points in the subcutaneous tissue, muscle and fascia and the control group subjected to laparotomy only. The rats were killed on postoperative day 7. Three types of assessment were performed: wound breaking strength, histopathology, and biochemical analysis. Results: Compared to the control group, rats in the ABS group displayed a lower wound breaking strength (p<0.05) and tissue hydroxyproline content (p<0.05). The use of ABS leads to a significant increase in malondealdehyde levels (p<0.05). Total histopathological score of groups were similar (p>0.05). Conclusion: Topical application of ABS to the subcutaneous tissue, muscle and fascia significantly impairs the wound healing by means of decreasing mechanical strength and tissue HPL levels.en_US
dc.identifier.endpage142en_US
dc.identifier.issn1108-5002en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27311
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofSurgical Chroniclesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnkaferden_US
dc.subjectMidline laparotomyen_US
dc.subjectWound dehiscenceen_US
dc.titleThe use of ankaferd might lead to wound dehiscence in midline laparotomy incisionen_US
dc.typeArticleen_US

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