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Öğe Clinical Experience of Interlocking Nail Stabilization of Long Bone Fractures in Dogs - A Retrospective Study of 26 Cases(ISRAEL VETERINARY MEDICAL ASSOC, 2017) Arıcan, Mustafa; Alkan, Feyzanur; Altan, Semih; Parlak, Kurtuluş; Yavru, NuriThe aim of the study is to report the clinical and radiographic outcome after use of an interlocking nail (ILN) for stabilization of long bone fractures in dogs. Twenty-six dogs were evaluated. There were ten femoral fractures, 12 tibial fractures and four humeral fractures. The equipment was manufactured by Orthovet (Orthovet, Izmir, Turkey). Three ILN lengths with three different diameters (4, 6 and 8 mm) were used. Each ILN had a trocar tip on one end and four screw holes (two distal and two proximal). Ten fractures (four femoral, five tibial, one humeral) were associated with other orthopedic problems. Nine (39.1%) patients had aseptic nonunion and malunion fractures. A static fixation mode was used for nine fractures and a dynamic fixation mode was used in 17 (65.3%). The surgical time recorded was 45-52 minutes. Three dogs had a major complication requiring surgical intervention. At 6 months, the functional outcome was excellent in 15 (57.6%) animals, good in seven (26.9%), fair in three (11.5%), and poor in one (3.8). In conclusion, the use of ILNs to repair diaphyseal fractures of the femur, tibia, and humerus in dogs resulted in a good or excellent functional outcome in most patients.Öğe Clinical experience of interlocking nail stabilization of long bone fractures in dogs – a retrospective study of 26 cases(Israel Veterinary Medical Association, 2017) Arıcan, Mustafa; Alkan, Feyzanur; Altan, Semih; Parlak, Kurtuluş; Yavru, NuriThe aim of the study is to report the clinical and radiographic outcome after use of an interlocking nail (ILN) for stabilization of long bone fractures in dogs. Twenty-six dogs were evaluated. There were ten femoral fractures, 12 tibial fractures and four humeral fractures. The equipment was manufactured by Orthovet (Orthovet, Izmir, Turkey). Three ILN lengths with three different diameters (4, 6 and 8 mm) were used. Each ILN had a trocar tip on one end and four screw holes (two distal and two proximal). Ten fractures (four femoral, five tibial, one humeral) were associated with other orthopedic problems. Nine (39.1%) patients had aseptic nonunion and malunion fractures. A static fixation mode was used for nine fractures and a dynamic fixation mode was used in 17 (65.3%). The surgical time recorded was 45-52 minutes. Three dogs had a major complication requiring surgical intervention. At 6 months, the functional outcome was excellent in 15 (57.6%) animals, good in seven (26.9%), fair in three (11.5%), and poor in one (3.8). In conclusion, the use of ILNs to repair diaphyseal fractures of the femur, tibia, and humerus in dogs resulted in a good or excellent functional outcome in most patients. © 2017, Israel Veterinary Medical Association. All rights reserved.Öğe Determination of the Efficiencies of the Prokinetics in Ruminants with Postoperative Ileus Using Pro-Inflammatory Markers(UNIV FED RIO GRANDE DO SUL, 2018) Altan, Semih; Donmez, Kaan; Altan, Feray; Alkan, FahrettinBackground: Recently, the role of inflammation triggered by handling of the intestine various gastrointestinal (GI) surgeries is generally accepted as the key event in postoperative ileus (POI). Because, prokinetics have been increased the smooth muscle contractions and may act by attenuating the inflammatory process in the GI tract, they have been used the treatment of POI in human and animals. There are many in vivo analysis techniques of GI motility. However, there have not yet been studied associated with the evaluation of the inflammatory response. Therefore, it was aimed to evaluate the efficiencies of 3 different prokinetics from inflammatory response during experimentally-induced POI. Materials, Methods & Results: Twenty healthy lambs (30-45 days old) were randomly assigned to four groups. In all groups, enterotomy was performed on the ileum. Erythromycin and metoclopramide were administered to the ERT and MET groups before the surgery, respectively, while lidocaine was administered to the LID group as bolus before and continuous rate infusion during the surgery. Physiological saline was administered to the lambs in control group as placebo before the surgery. Blood samples were collected before surgery (similar to 30-45 min), at the end of surgery (0 h), and at the postoperative 1, 3, 5, 10, 48, 72 and 96 h. The concentrations of serum amyloid A (SAA), haptoglobin (HPT), fibrinogen (FIB) as acute phase proteins (APPs), thiobarbituric acide reactant substrate (TBARs), myeloperoxidase (MPO) as reactive oxygen species, and transforming growth factor-beta (TGF-beta) as a cytokine were measured with ELISA reader. In terms of time points, it was found that FIB was statistically higher in ERT group at the 1st h, in MET and LID groups at the 10th h, and in LID group at the 48th and in MET group at the 72 h (P < 0.05). It was found that SAA was higher in MET group at the 1st, 3rd, 5th, 10th, 24th, 48th and 72nd h. HPT was higher in CNTR group until 72th h and MET group at 48th, 72nd and 96th h. TBARs concentrations were statistically higher in MET and LID groups at 0 hour, in ERT and MET groups at the 1st h, in MET group at the 3rd h, in MET and LID groups at the 5th and 10th h, in MET group at the 48th, 72nd and 96th h (P < 0.05). MPO concentrations was higher in LID group at the 3rd, 5th, 10th and 96th h, and in ERT group at the 72nd h (P < 0.05). TGF-beta concentrations were particularly high in MET group at the 3rd, 5th, 48th and 72nd h, and in LID group at the 10th, 24th, and 96th h (P < 0.05). Discussion: APPs (HPT, SAA, FIB), which are important regulators of inflammation in cows and sheep, were higher generally in MET and LID groups and inflammation persists in these two groups and, therefore, metoclopramide and lidocaine are less effective in early postoperative POI treatment. Because, significant increase in serum TBARs and MPO concentrations was considered as an important indicator of oxidative stress and inflammatory response MPO concentrations was particularly high until 10th h in LID group, and TBARs concentrations was high both MET and LID groups throughout the study, this was correlated with higher neutrophil infiltration in the postoperative early period than the other groups. It is known that TGF-beta, an inflammatory cytokine, is correlated with various smooth muscle disorders in humans. In this study, TGF-beta concentration were higher in the MET and LID groups. High concentration of this cytokine might have led to decrease contractions in smooth muscles, thereby slowing down the intestinal transition. In conclusion, based on the presence of pro-inflammatory markers in this study, erythromycin seems to be the most suitable prokinetic drug in lambs. Moreover, lidocaine and metoclopramide are not as successful in small ruminants as reported in other species.Öğe Dimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burns(ELSEVIER SCI LTD, 2017) Altan, Semih; Ogurtan, ZekiIntroduction: In this study, we aimed to investigate the effect of indomethacin and dimethyl sulfoxide (DMSO), well-known antioxidant and anti-inflammatory agents, to heal eye burns induced with hydrofluoric acid in rabbits. Methods: After general anesthesia, the right eye of 72 male New Zealand rabbits were burned by instillation of 2% hydrofluoric acid for 60 s. Following this, the eyes were irrigated with 500 cc normal saline. The rabbits were then divided into four groups of 18 rabbits each. Group D was instilled dimethyl sulfoxide 40%, Group I indomethacin 0.1%, and Group DI dimethyl sulfoxide together with indomethacin for 2, 7, and 14 treatment days, respectively. Group C received no instilled drug as control. Treatment efficacies were evaluated as clinical (corneal haziness, conjunctival status, conjunctivitis, corneal erosion area, and intraocular pressure) and histopathological (inflammatory cell infiltration, vascularization, stromal thickness, reepithelization, proliferating cell nuclear antigen [PCNA], apoptosis, and inducible nitric oxide synthases [iNOS]). Results: In terms of corneal haziness and erosion area at days 7 and 14, group D showed the best result statistically as compared to the other groups. This group also showed the best result statistically for reepithelization rate, stromal thickness, and inflammatory cell end at day 14 as compared to the other groups. Conclusions: Dimethyl sulfoxide (40%) was efficient to induce reepithelization on mild hydrofluoric acid eye burns, whereas 0.1% indomethacin both alone and along with DMSO poorly induced reepithelization and exacerbated inflammation. Thus, 40% DMSO could be used for the treatment of corneal disorders. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.Öğe Ectopic Reticulum in a Cow(UNIV AGRICULTURE, FAC VETERINARY SCIENCE, 2016) Altan, Semih; Koc, Yilmaz; Alkan, Fahrettin; Erol, Muharrem; Yildiz, RamazanA two years-old Holstein cow with poor appetite, reduced milk production, and partial defecation was evaluated in the present case report. After routine laboratory and clinical examinations, the animal further received ultrasound examination and then a right fossa paralumbal exploratory laparotomy was performed to the cow. The cow was diagnosed with ectopic reticulum on the laparotomy. After the content of the reticulum was removed, liquid paraffin was administered into the reticulum and its wall and abdominal wall was sutured as routinely. The prognosis of the animal deteriorated gradually following to the laparotomy and it was slaughtered by its owner. This is the first report showing the presence of an ectopic reticulum in a cow. (C) 2016 PVJ. All rights reservedÖğe Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse(2019) Altan, Feray; Erol, Hanifi; Altan, Semih; Arıcan, Mustafa; Elmas, Muammer; Üney, KamilThe negative impact of multiple ascending doses of cefquinome (CFQ) on hematological and serum biochemical profile of horseunknown. The objective of this study was to evaluate the effect of multiple ascending doses of cefquinome (CFQ) in horses on thefollowing hematological (WBCs, LYM, MON, GRA, RBCs, HB, HT, MCV, MCH, MCHC, RDW, and PLT) and biochemical parameters (ALB,ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG, and BUN). The study was performed on the sixteen mature horses (4.6 2.1 years, 302 38 kg). Four dosages of CFQ were applied as Group I; 1 mg/kg, Group II; 2 mg/kg, Group III; 4 mg/kg and Group IV; 6 mg/kg, and eachanimal received intravenously a total of 13 injections, administered every 12 h for 7 days. The hematological and biochemicalparameters of horses were monitored on the before 0 day and 1, 3, 7, and 14 days after the administration of the first CFQ. Nosignificant differences in serum biochemical parameters were found amongst the groups (p0.05). Significant differences were found incertain hematological parameters (MONO, GRAN, RBC, HB, HCT, MCH, and PCT) amongst the groups (p0.05) within the referenceranges. These results indicate that the administration of multiple doses of up to 6 mg/kg of CFQ in the horse had no clinically significantimpact on the blood parameters measured.Öğe The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2018) Altan, Semih; Donmez, Kaan; Altan, Feray; Alkan, FahrettinThe aim of this study was to evaluate the effects of the three different prokinetic agents, namely erythromycin, lidocaine, and metoclopramide in lambs with postoperative ileus (POI) using motilin and ghrelin, which are known as motility markers. Twenty lambs were allocated to 4 groups of 5 lambs each. An enterotomy was performed on the ileum of each lamb. Erythromycin (8.8 mg/ kg), metoclopramide (0.2 mg/kg), and saline (2 mL) were administered as single dose IM before surgery in the ERT, MET, and CNTR groups, respectively. Lidocaine was administered to the LID group, both as a bolus before (1.3 mg/kg IV) and as a continuous rate infusion during surgery (0.05 mg/kg/h IV). Serwn motilin and ghrelin concentrations as motility hormones were measured with ELISA. The serum motilin concentration was significantly higher at 0, 1, 3, 5, 10, 24, and 48 h in the ERT group and at 1 and 10 h in the LID group. The serum ghrelin concentration was significantly higher at 0, 1, and 48 h in the ERT group and at 3, 5, 10, 24, and 48 h in the LID group. As a result, erythromycin and lidocaine was thought to be useful in lambs with POI according to the stimulatory effects on the motility hormones.Öğe Evaluation of bacterial translocation in cats undergoing laparotomy(Selçuk Üniversitesi Veteriner Fakültesi, Eylül 2022) Altan, Semih; Alp, Simten YeşilmenAmaç: Kedilerde intraabdominal basıncı arttırdığı düşünülen ya da bağırsak duvarına basınç yapan patolojilere yönelik laparotomi uygulamalarında bakteriyel translokasyonun (BT) varlığının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Selçuk Üniversitesi Hayvan Hastanesine getirilen, klinik, laboratuar, ultrasonografik ve radyografik muayene sonucu laparotomi kararı alınan 25 kedi değerlendirildi. Operasyon esnasında abdominal bölgeye girildikten hemen sonra periton sıvısından ve uygun olan bir mezenteriyel lenf nodülünden (MLN) steril swap ile sürüntü örnekleri alındı. Bakteriyel suşların tanımlanması gerçekleştirildi ve oluşan bakteriyel spektrumlar analiz edildi. Bakteriyel suşların antibiyotik direnci Kirby-Bauer disk difüzyon metodu ile belirlendi. Bulgular: 25 kedinin 4’ünde (%16) yabancı cisim nedeniyle bağırsak perfüzyonunun bozulmasına bağlı BT saptandı. BT’nin 2’si sadece MLN’den 2’si ise hem periton boşluğu hem de MLN’den alınan swab örneklerinden izole olduğu belirlendi. Peritonda üreyen bakterilerin %50’sini E. faecalis (n=2), %50’sini ise E. faecium (n=2) oluşturduğu belirlenirken lenf yumrusundan alınan örneklerde P. fluorescens ve E. faecalis bakterilerinin ürediği belirlendi. Öneri: İntraabdominal basıncı ya da bağırsak duvarını etkileyen patolojilerin varlığında akla BT gelmelidir. Özellikle bağırsak duvarına doğrudan etki eden (yabancı cisim, konstipasyon, obstipasyon vb.) patolojilerde BT şüphesinin daha da artması gerektiği düşünülmektedir. Antibiyogram yapılarak spesifik antibiyotik kullanımının prognoz açısından daha olumlu olacağı düşünülmektediÖğe Evaluation of bacterial translocation in cats undergoing laparotomy(Selçuk Üniversitesi, 2022) Parlak, Kurtuluş; Altan, Semih; Alp, Simten Yeşilmen; Akyol, Eyüp Tolga; Uzunlu, Elgin Orcum; Zamirbekova, Nuriza; Alkan, FahrettinAim: This study aimed to evaluate the presence of bacterial translocation (BT) in cats undergoing laparotomy procedures for pathologies that are thought to increase intra-abdominal pressure or pressurize the intestinal wall. Materials and Methods: Twenty-five cats were evaluated that refered to Selcuk University Animal Hospital for laparotomy after the clinical, laboratory, ultrasonographic and radiographic examinations. Sterile swab samples were taken from the peritoneal fluid and an appropriate mesenteric lymph nodes (MLN) immediately after reaching the abdominal region during the laparatomy. Identification of bacterial strains was carried out and bacterial spectra were analyzed. Antibiotic resistance of bacterial strains was determined by the Kirby-Bauer disc diffusion method. Results: BT was diagnosed in 4 (16%) of 25 cats as a result of deteriorated intestinal perfusion due to foreign body. It was determined that 2 of the BT were isolated from swap samples taken from only MLNs and 2 of them were isolated from swap samples taken from both the peritoneal cavity and MLNs. It was determined that 50% of the bacteria growing in the peritoneum were E. faecalis (n=2) and 50% were E. faecium. It was determined that the bacteria growing in the MLNs formed P. fluorescens and E. faecalis. Conclusion: BT should be considered in the presence of pathologies that affect intra-abdominal pressure or affect the intestinal wall. It is thought that the suspicion of bacterial translocation should increase in pathologies that directly affectthe intestinal wall. Itis thoughtthatthe use of specific antibiotics will be more positive in terms of prognosis by performing an antibiogram.Öğe Evaluation of the outcomes of right paralumbar fossa colostomy for type II colonic atresia in calves: a report of 24 cases(POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE, 2019) Erol, Muharrem; Erol, Hanifi; Altan, Semih; Yavru, NuriThe aim of the present study was to evaluate the effectiveness of right fossa paralumbar colostomy on the survival rate of calves with atresia coli maintained under Anatolian farming conditions. The clinical diagnosis was confirmed by clinical findings, pain and contrast radiographic examination. In clinical and indirect radiographic examination, rectum and descending colon were seen as more constricted than usual. In surgery, the abdominal cavity was opened through a vertical incision from the right paralum bar fossa. The blind end of the ascending colon was fixed to the abdominal wall in order to create a stoma. The postoperative course of the calves was obtained from the owners of the calves during a period of four months. It was learned that only one calf survived and the others died because of diarrhea within the four month period. In conclusion, this study demonstrated that although right fossa paralumbar colostomy was successfully performed for type-II atresia coli, severe functional impairment and fluid imbalance due to the loss of an important fluid resorption resulted in the death of most calves that were kept under Anatolian farming conditions.Öğe Hematologic, Blood Gas, Cardiac Biomarkers and Serum Biochemical Parameters in Calves with Atresia Coli and Theirs Relationship with Prognosis(UNIV FED RIO GRANDE DO SUL, 2017) Coskun, Alparslan; Aydogdu, Ugur; Altan, Semih; Erol, Muharrem; Erol, Hanifi; Guzelbektes, Hasan; Sen, IsmailBackground: Atresia coli is an intestinal anomaly. Generally, absence of defecation in calves less than 10 days old, diminishing appetite, progressing abdominal distention and time-developing depression are reported in atresia coli. Although a calf consumes its milk normally in first days, loss of appetite develops over time. Occasional minor pain indications are observed. The objective of this study was to evaluate of hematologic, blood gases, cardiac biomarkers and serum biochemical parameters before operation in calves with atresia coli, and to investigate relationship with prognosis of these parameters. Materials, Methods & Results: Thirty calves with atresia coli and 6 healthy calves for control were used as material. Poor suction reflex, anorexia, dehydration, abdomen-kicking, frequent leg movement, abdominal distension and depression were observed in calves brought to the clinic. Some calves presented swashing sound depending on content of intestines when abdomen was shaken. Intestine atresia was diagnosed by history and clinical examination. After clinical examination, operation was performed. All calves were observed during 10 days after operation. Fifteen of 30 calves died during 10 days after operation. The blood lactate, WBC, LDH and CK-MB levels in non-surviving calves with atresia coli were significantly higher compared to control calves. The venous blood pH level was significantly lower in non-surviving calves compared to surviving calves. In addition, when compared to the control group, the blood pCO(2) level was significantly higher in non-surviving and surviving calves with atresia coli while the pO(2) and O-2 saturation levels were significantly lower. Discussion: In calves with intestinal atresia, hematologic parameters are normal in first 48 h of disease. However, leukocytosis and shift to the left have been reported over time. However, leukocytosis due to peritonitis, bacterial overgrowth, etc. have been reported over time. It was seen that leukocyte numbers of non-surviving calves with atresia coli in this study were significantly higher, but leucocyte increase in surviving calves was seen to be statistically insignificant. Leukocyte increased in non-surviving calves with atresia may be associated with excessive bacterial reproduction and peritonitis. Blood lactate level is a commonly used marker for severity of disease in humans and lactate has a prognostic value in adult horses with colic and foals with critical disease. In this study, lactate level in non-surviving calves with atresia coli was significantly higher with respect to surviving calves and control calves. In this result, lactate can be evaluated as a prognostic indicator in calves with atresia coli. Creatine kinase-MB fraction and troponins are used in determination of cardiac damage in veterinary medicine. The fact that serum blood cTnI and CK-MB levels of non-surviving calves with intestinal atresia in this study were higher than surviving calves with atresia coli and control calves suggested that endotoxemia related cardiac damage may have developed. Surgical operation is necessary in the treatment of intestinal atresia. It was determined that the importance of calves age and colon integrity during time of surgical operation in survival of calves with atresia coli. The studies showed that survival rate in surgical operation conducted on calves under 3 days old was higher than calves over 5 day-old. Average of age of non-surviving calves with atresia coli in this study (4.67 +/- 1.23 days) was higher than average of age of surviving calves with atresia coli (3.27 +/- 0.51 days). It was also observed in our study that elapsed time affected prognosis of calves negatively. Thus, performing surgical operations as soon as possible may raise survival rate of calves with intestinal atresia as stated in previous studies.Öğe Incisor malocclusions in a rabbit(2011) Altan, Semih; Goksahin, EbruTavşanlar, pet hayvanlar arasında en çok beslenen hayvanlardan biri olmasına rağmen sahipleri tarafından düzgün bir beslenme rejimi uygulanmaz. Bu durum dişlerin sürekli büyümesiyle orantılı olarak özellikle dişlerde hastalıklara neden olabilir. İştahsızlık şikayeti ile Cerrahi kliniğe getirilen erişkin bir Yeni Zelanda tavşanında yapılan ağız muayenesi ve çift yönlü radyografi neticesinde alt ve üst kesici dişlerde maloklüzyonlar saptandı. Yapılan hemosel, kan gazı ve bazı serum biyokimyasal analizlerde hematokrit, hemoglobin ve kalsiyum seviyelerindeki düşüklük dışındaki değerler referans aralığında ölçüldü. Sonuç olarak, tavşanlar, dental problemler yönünden veteriner hekimler tarafından rutin olarak muayene edilmesi gerekir.Öğe Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep(ELSEVIER SCIENCE BV, 2019) Altan, Feray; Çorum, Orhan; Çorum, Duygu Durna; Altan, Semih; Üney, KamilThe pharmacokinetics of marbofloxacin (MBX) was determined following the intramuscular administration at the doses of 2, 4, 6, and 10 mg/kg in twenty-four healthy sheep. In parallel design, sheep were randomized to 2, 4, 6, and 10 mg/kg dose groups of six animals per group. High performance liquid chromatography method for determination of MBX in sheep plasma was used. Pharmacokinetic parameters were calculated by a non-compartmental method. The dose-normalized the area under the concentration-versus-time curve (AUC(0-infinity)) and dose-normalized maximum plasma concentration (C-max) in 10 mg/kg dose group were significantly higher than other dose groups. The elimination half-life (t(1/2 lambda z)) of marbofloxacin in 10 mg/kg dose group was significantly longer than other dose groups. MBX exhibited dose-proportional pharmacokinetics and was well tolerated after 2, 4, 6 and 10 mg/kg doses in sheep. The 2, 4, 6, and 10 mg/kg doses of MBX could be administered in the treatment of infections caused by susceptible pathogens in sheep. However, additional studies are needed to identify whether MBX is efficient in sheep of naturally infected with susceptible bacteria.Öğe Plasma and synovial fluid pharmacokinetics of cefquinome following the administration of multiple doses in horses(WILEY, 2017) Üney, Kamil; Altan, Feray; Altan, Semih; Erol, Hanifi; Arıcan, Mustafa; Elmas, MuammerThe plasma and synovial fluid pharmacokinetics and safety of cefquinome, a 2-amino-5-thiazolyl cephalosporin, were determined after multiple intravenous administrations in sixteen healthy horses. Cefquinome was administered to each horse through a slow i.v. injection over 20min at 1, 2, 4, and 6mg/kg (n=4 horses per dose) every 12h for 7days (a total of 13 injections). Serial blood and synovial fluid samples were collected during the 12h after the administration of the first and last doses and were analyzed by a high-performance liquid chromatography assay. The data were evaluated using noncompartmental pharmacokinetic analyses. The estimated plasma pharmacokinetic parameters were compared with the hypothetical minimum inhibitory concentration (MIC) values (0.125-2g/mL). The plasma and synovial fluid concentrations and area under the concentration-time curves (AUC) of cefquinome showed a dose-dependent increase. After a first dose of cefquinome, the ranges for the mean plasma half-life values (2.30-2.41h), the mean residence time (1.77-2.25h), the systemic clearance (158-241mL/h/kg), and the volume of distribution at steady-state (355-431mL/kg) were consistent across dose levels and similar to those observed after multiple doses. Cefquinome did not accumulate after multiple doses. Cefquinome penetrated the synovial fluid with AUC(synovial fluid)/AUC(plasma) ratios ranging from 0.57 to 1.37 after first and thirteenth doses, respectively. Cefquinome is well tolerated, with no adverse effects. The percentage of time for which the plasma concentrations were above the MIC was >45% for bacteria, with MIC values of 0.25, 0.5, and 1g/mL after the administration of 1, 2, and 4 or 6mg/kg doses of CFQ at 12-h intervals, respectively. Further studies are needed to determine the optimal dosage regimes in critically ill patients.Öğe Retrospective evaluation of canine neoplasms in Konya region between 2006 and 2010(Selçuk Üniversitesi Veterinerlik Fakültesi, 2013) Altan, Semih; Alkan, Fahrettin; Koç, Yılmaz; Özdemir, Özgür; Yavuz, OrhanAmaç: Bu çalışmada 2006-2010 yılları arasında üniversite hayvan hastanesine getirilen 58 köpekte klinik, radyolojik, operatif ve histopatolojik muayeneleri neticesinde teşhis edilen neoplazma vakalarının geriye dönük değerlendirilmesi yapıldı. Gereç ve Yöntem: Tümöral vakalar köpeklerin ırk, yaş ve cinsiyetine, tümörlerin özellikleri ve yerleşim yerleriyle birlikte tedavi şekillerine göre değerlendirildi. Bulgular: Tümörlerin %48.3’üne cerrahi uygulama, %20 .7’sine kemoterapi, %5.2’sine hem cerrahi hem kemoterapi ve %13.8’ine ise levamizol ve/veya otovaksinasyon uygulandı. Köpeklerin %12’sine ise ötenazi uygulandı. Kemoterapi, transmissible venereal tümör vakalarında yapılırken, papilloma vakalarında levamizol ve otovaksinasyon yapıldı. Tümörlerin %53.4’ü benign karakterde iken %46’6’sı malign karakter gösterdiği belirlendi. Öneri: Bu değerlendirme ile Konya ve yöresindeki köpeklerde gözlenen tümöral vakalar ve bunların tedavi sonuçları ortaya konmuştur. Ayrıca, venereal tümörler kemoterapi uygulamasıyla (vinkristin), papillomlar ise levamizol ve otovaksinasyon işlemiyle tedavi edilebilirÖğe Retrospective evaluation of canine neoplasms in Konya region between 2006 and 2010(2013) Altan, Semih; Alkan, Fahrettin; Koç, Yılmaz; Özdemir, Özgür; Yavuz, OrhanAmaç: Bu çalışmada 2006-2010 yılları arasında üniversite hayvan hastanesine getirilen 58 köpekte klinik, radyolojik, operatif ve histopatolojik muayeneleri neticesinde teşhis edilen neoplazma vakalarının geriye dönük değerlendirilmesi yapıldı. Gereç ve Yöntem: Tümöral vakalar köpeklerin ırk, yaş ve cinsiyetine, tümörlerin özellikleri ve yerleşim yerleriyle birlikte tedavi şekillerine göre değerlendirildi. Bulgular: Tümörlerin %48.3'üne cerrahi uygulama, %20 .7'sine kemoterapi, %5.2'sine hem cerrahi hem kemoterapi ve %13.8'ine ise levamizol ve/veya otovaksinasyon uygulandı. Köpeklerin %12'sine ise ötenazi uygulandı. Kemoterapi, transmissible venereal tümör vakalarında yapılırken, papilloma vakalarında levamizol ve otovaksinasyon yapıldı. Tümörlerin %53.4'ü benign karakterde iken %46'6'sı malign karakter gösterdiği belirlendi. Öneri: Bu değerlendirme ile Konya ve yöresindeki köpeklerde gözlenen tümöral vakalar ve bunların tedavi sonuçları ortaya konmuştur. Ayrıca, venereal tümörler kemoterapi uygulamasıyla (vinkristin), papillomlar ise levamizol ve otovaksinasyon işlemiyle tedavi edilebilir.Öğe The right displacement of abomasum with ulceration in a calf(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2012) Altan, Semih; Alkan, Fahrettin; Koc, YilmazThe aim of this case report is to describe the clinical, ultrasonographic, and surgical findings in an 8-week-old female Holstein calf with right abomasal displacement and ulceration. Auscultation/percussion, auscultation/ballottement, and ultrasound examination were used to identify displacement of the abomasum. Right-flank laparotomy was used for repositioning of the displaced abomasum. The abomasum was greatly distended between the rumen and right body wall. Approximately 7 L of abomasal content was discharged from the abomasum. A few ulcerative areas in the mucosal surface of abomasum were observed. After surgery, antimicrobial and antiulcerative therapy were given. The calf discharged was followed with telephonically. As a result, right displacement of the abomasum is very rarely seen in calves. Right flank laparotomy gives good result in calves with right displaced abomasum, and ultrasound examination helps to distinguish right displaced abomasum from other metabolic disorders of the digestive tract in calves.Öğe The right displacement of abomasum with ulceration in a calf(Veteriner Fakultesi Dergisi, 2012) Altan, Semih; Alkan, Feyzanur; Koç, YılmazThe aim of this case report is to describe the clinical, ultrasonographic, and surgical findings in an 8-week-old female Holstein calf with right abomasal displacement and ulceration. Auscultation/percussion, auscultation/ballottement, and ultrasound examination were used to identify displacement of the abomasum. Right-flank laparotomy was used for repositioning of the displaced abomasum. The abomasum was greatly distended between the rumen and right body wall. Approximately 7 L of abomasal content was discharged from the abomasum. A few ulcerative areas in the mucosal surface of abomasum were observed. After surgery, antimicrobial and antiulcerative therapy were given. The calf discharged was followed with telephonically. As a result, right displacement of the abomasum is very rarely seen in calves. Right flank laparotomy gives good result in calves with right displaced abomasum, and ultrasound examination helps to distinguish right displaced abomasum from other metabolic disorders of the digestive tract in calves.Öğe Surgical treatment of a calf with jejunum intussusception: Case report(Selçuk Üniversitesi Veterinerlik Fakültesi, 2015) Erol, Muharrem; Altan, Semih; Erol, HanifiBu vaka sunumunda 5 aylık bir erkek buzağıda teşhis edilen jejunum invaginasyonunun klinik, laboratuar ve operasyon bulguları değerlendirildi. Tanımlanan klinik vakada hayvanın 3 gündür iştahsız olduğu ve defekasyon yapmadığı sahibinden öğrenildi. İç Hastalıkları kliniğinde yapılan klinik ve laboratuar muayenelerinden sonra hayvan cerrahi kliniğine sevk edildi. Sol açlık çukurluğundan laporatomi operasyonu yapıldı. Operasyonda bağırsaklar patolojik vaziyet değişikliği yönünden kontrol edildi. Operasyon esnasında yapılan muayenede ventral hattın hafif sağında katı kıvamlı bağırsak segmenti palpe edildi. Palpe edilen bağırsak segmenti karın boşluğundan çıkarıldığında invagine olmuş jejunum olduğu görüldü. İnvagine kısım ödematöz, siyanotik ve fibröz adezyonların bulunmasından dolayı rezeksiyonu ve uç uca anostomozu yapıldı. Taburcu edilen buzağı hakkında hasta sahibinde bilgi alındı. Sonuç olarak bağırsak invaginasyonunun 5 aylık buzağılarda nadiren görüldüğü, teşhisinin experimental laparotomi ile koyulabileceği ve bu sürede rutin cerrahi operasyon ile tedavisinin yapılabileceği kanısına varıldı.Öğe Surgical treatment of a calf with jejunum intussusception: Case report(2015) Erol, Muharrem; Erol, Hanifi; Koç, Yılmaz; Altan, SemihBu vaka sunumunda 5 aylık bir erkek buzağıda teşhis edilen jejunum invaginasyonunun klinik, laboratuar ve operasyon bulguları değerlendirildi. Tanımlanan klinik vakada hayvanın 3 gündür iştahsız olduğu ve defekasyon yapmadığı sahibinden öğrenildi. İç Hastalıkları kliniğinde yapılan klinik ve laboratuar muayenelerinden sonra hayvan cerrahi kliniğine sevk edildi. Sol açlık çukurluğundan laporatomi operasyonu yapıldı. Operasyonda bağırsaklar patolojik vaziyet değişikliği yönünden kontrol edildi. Operasyon esnasında yapılan muayenede ventral hattın hafif sağında katı kıvamlı bağırsak segmenti palpe edildi. Palpe edilen bağırsak segmenti karın boşluğundan çıkarıldığında invagine olmuş jejunum olduğu görüldü. İnvagine kısım ödematöz, siyanotik ve fibröz adezyonların bulunmasından dolayı rezeksiyonu ve uç uca anostomozu yapıldı. Taburcu edilen buzağı hakkında hasta sahibinde bilgi alındı. Sonuç olarak bağırsak invaginasyonunun 5 aylık buzağılarda nadiren görüldüğü, teşhisinin experimental laparotomi ile koyulabileceği ve bu sürede rutin cerrahi operasyon ile tedavisinin yapılabileceği kanısına varıldı.
