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Öğe Diagnostic importance of deoxypyridinoline and osteocalcine in equine osteoarthritis(VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2004) Arican, M; Koylu, O; Uyaroglu, A; Erol, M; Calim, KNIn this study, deoxypyridinoline (Dpd) and osteocalcine (OC), which has been considered as a diagnostic and prognostic marker for joint disease in man and dog, was measured in urine from horses with osteoarthritis (OA). Serum and urinary assays of bone markers provide a noninvasive alternative to bone biopsy in the study of bone metabolism in horses. No significant differences in serum osteocalcine were found in either group. However, significant diferences were found in deoxypyridinoline/creatinine ratio between normal and OA urine. They may be useful in the monitoring of therapy and prognosis in horses with osteoarthritis. The measurement of collagen crosslink, deoxypyridinoline is comparatively more specific to monitor bone resorption. This article reviews the use of different bone marker, in veterinary medicine and the possibilities for diagnosing and preventing bone diseases of horses.Öğe Metalloproteinases in canine experimental traumatic keratoconjunctivitis(WILEY, 1999) Arican, M; Ceylan, CMatrix metalloproteinases (MMPs) are thought to be involved in eye disease and may be present in tears. MMP activity was measured by gelatine zymography. Active gelatinase levels were determined by a gelatine degradation ELISA. Potential MMP-9 (gelatinase-B) monomer enzyme activity was elevated (P < 0.001) in keratoconjunctivitis in comparison to normal tears, MMP-9, dimer form, enzyme activity was elevated (P < 0.001) in fluids from keratoconjunctivitis cases in comparison to fluids from normal eyes. Significant increases in gelatinase bioactivities were seen in tears from keratoconjunctivitis disease cases (P < 0.01). Enzymes in dogs with eye disease were biologically active indicating that both the active forms of the enzyme were present. Hence, they could be an important indicator in deterioration of the cornea during eye disease.Öğe A new neuroimplantable device: The tulgar implant. Initial results of animal testing(WILEY, 2005) Kalkan, E; Arican, M; Kalkan, SS; Erayman, I; Erol, A; Tulgar, AO; Tulgar, MA new neuroimplant system, namely the Tulgar implant, developed to solve the practical problems encountered with the presently available implants, was tested as a spinal cord stimulator in ten sheep. The response of living tissue and technical performance of the new system were evaluated. Electrodes implanted in the low thoracic (T9-10) vertebral levels by means of hemilaminectomy were subcutaneously connected to the passive coil receiver element located in the anterior-inferior chest wall for 28 days. Laboratory parameters including hematology, biochemistry, and microbiology were investigated over the study, and histopathologic examinations were done by the end of study. Animal tests showed that the new system could reliably be implantable in the living tissue. Intra-operative radicular stimulation of the right dorsal root in T13-L1 levels, by means of burst mode of signals, resulted in observable contractions of hip muscles in the right upper leg.Öğe Treatment of bilateral olecranon bursitis in a horse(INDIAN VETERINARY JOURNAL, 2005) Arican, M; Kocabiyik, A; Izci, C[Abstract not Available]
