Metalloproteinases in canine experimental traumatic keratoconjunctivitis
Küçük Resim Yok
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Matrix metalloproteinases (MMPs) are thought to be involved in eye disease and may be present in tears. MMP activity was measured by gelatine zymography. Active gelatinase levels were determined by a gelatine degradation ELISA. Potential MMP-9 (gelatinase-B) monomer enzyme activity was elevated (P < 0.001) in keratoconjunctivitis in comparison to normal tears, MMP-9, dimer form, enzyme activity was elevated (P < 0.001) in fluids from keratoconjunctivitis cases in comparison to fluids from normal eyes. Significant increases in gelatinase bioactivities were seen in tears from keratoconjunctivitis disease cases (P < 0.01). Enzymes in dogs with eye disease were biologically active indicating that both the active forms of the enzyme were present. Hence, they could be an important indicator in deterioration of the cornea during eye disease.
Açıklama
Anahtar Kelimeler
Kaynak
JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
46
Sayı
9