Metalloproteinases in canine experimental traumatic keratoconjunctivitis

Küçük Resim Yok

Tarih

1999

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

WILEY

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Matrix metalloproteinases (MMPs) are thought to be involved in eye disease and may be present in tears. MMP activity was measured by gelatine zymography. Active gelatinase levels were determined by a gelatine degradation ELISA. Potential MMP-9 (gelatinase-B) monomer enzyme activity was elevated (P < 0.001) in keratoconjunctivitis in comparison to normal tears, MMP-9, dimer form, enzyme activity was elevated (P < 0.001) in fluids from keratoconjunctivitis cases in comparison to fluids from normal eyes. Significant increases in gelatinase bioactivities were seen in tears from keratoconjunctivitis disease cases (P < 0.01). Enzymes in dogs with eye disease were biologically active indicating that both the active forms of the enzyme were present. Hence, they could be an important indicator in deterioration of the cornea during eye disease.

Açıklama

Anahtar Kelimeler

Kaynak

JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

46

Sayı

9

Künye