Metalloproteinases in canine experimental traumatic keratoconjunctivitis

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dc.contributor.authorArican, M
dc.contributor.authorCeylan, C
dc.date.accessioned2020-03-26T16:27:12Z
dc.date.available2020-03-26T16:27:12Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMatrix metalloproteinases (MMPs) are thought to be involved in eye disease and may be present in tears. MMP activity was measured by gelatine zymography. Active gelatinase levels were determined by a gelatine degradation ELISA. Potential MMP-9 (gelatinase-B) monomer enzyme activity was elevated (P < 0.001) in keratoconjunctivitis in comparison to normal tears, MMP-9, dimer form, enzyme activity was elevated (P < 0.001) in fluids from keratoconjunctivitis cases in comparison to fluids from normal eyes. Significant increases in gelatinase bioactivities were seen in tears from keratoconjunctivitis disease cases (P < 0.01). Enzymes in dogs with eye disease were biologically active indicating that both the active forms of the enzyme were present. Hence, they could be an important indicator in deterioration of the cornea during eye disease.en_US
dc.identifier.doi10.1046/j.1439-0442.1999.00238.xen_US
dc.identifier.endpage532en_US
dc.identifier.issn0931-184Xen_US
dc.identifier.issue9en_US
dc.identifier.pmid10605362en_US
dc.identifier.startpage527en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1439-0442.1999.00238.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16959
dc.identifier.volume46en_US
dc.identifier.wosWOS:000083767500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMetalloproteinases in canine experimental traumatic keratoconjunctivitisen_US
dc.typeArticleen_US

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