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Öğe Angel wings syndrom in swans (cygnus cygnus and cygnus atratus)(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2019) Arican, Mustafa; Parlak, Kurtulus; Yalcin, MustafaIn the present study 6 male swans two black (Cygnus atratus) and four white (Cygnus cygnus), weighing about 5.5-7.5 kg, with bilateral wing sagging and turning out of the wing tips belonging to Parks and Gardens Directorate of Metropolitan Municipality were used as materials. The swans were being fed on daily ration (pellet feed) as well as food residues such as bread, bagels, chips, etc. thrown by visitors. The clinical examination revealed that developing feathers and the tips of the wings of swans were stuck up from its normal position. The wings of the swans were bandaged adjacent to their bodies for one week and their rations were arranged. Angel wings have a high chance of being treated if the problem is diagnosed early.Öğe Characterization of dental pulp defect and repair in a canine model(MOSHER & LINDER, INC, 2011) Yildirim, Sibel; Can, Alp; Arican, Mustafa; Embree, Mildred C.; Mao, Jeremy J.Purpose: To explore a relationship between the size of pulp chamber perforation and reparative dentin formation in a canine model. Methods: Pulp defects were created in the pulp chambers of maxillary and mandibular premolars (N=64) in 17 healthy mongrel dogs in three different sizes (diameter/depth: 1/1, 2/1, and 2/2 mm(3)) with sterile round burs under general anesthesia. The perforations were immediately capped with hard-setting calcium hydroxide (CH) in the control group or sealed with Teflon membrane (TM) in the experimental group, followed by restoration with reinforced zinc oxide eugenol cement in vivo. Seven and 30 days after pulp chamber perforation and restoration all treated and control premolars were extracted and prepared for histomorphometric and statistical analyses. Results: Reparative dentin formation was more pronounced for defect sizes up to 2/1 mm(3) when treated with CH, and completely bridged the surgically created dentin defects only after 30 days. However, reparative dentin upon CH treatment failed to completely bridge pulp chamber exposure for 2/2 defects. By contrast, TM treatment only yielded mild reparative dentin bridging for defects up to 1/1, but not for either 2/1 or 2/2 defects at 30 days. Inflammatory responses of the exposed dental pulp tissue were more robust with the TM group than with the CH group. Thus, dental pulp tissue possesses a capacity for spontaneous repair by the formation of reparative dentin in this preclinical model, but only up to a defect size of similar to 2 mm in diameter and 1 mm in depth. All observations are based on 30 days post-treatment in the canine model. These findings may serve as baseline for regenerative endodontic studies (Am J Dent 2011;24:331-335).Öğe Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses(UNIV AGRICULTURE, FAC VETERINARY SCIENCE, 2015) Arican, Mustafa; Erol, Hanifi; Esin, EvrenThe effects of anesthesia using medetomidine combined with isoflurane or sevoflurane on hemodynamic parameters, blood biochemistry, and intraocular pressure was evaluated in horses. Healthy horses (n=12) with a mean body weight of 438 +/- 51kg were used. Premedication was provided by administering medetomidine (7 mu g/kg) intravenously (IV), and general anesthesia was induced by administering ketamine (2.2 mg/kg) and midazolam (0.03 mg/kg) IV after which isoflurane (n=6) or sevoflurane (n=6) was administered for inhalation anesthesia. Blood gases, respiratory rate, heart rate, electrocardiogram, body temperature, and oxygen saturation, as well as systolic, diastolic, and mean arterial blood pressure were recorded at 0, 5, 15, 30, and 60 min after administering medetomidine. Statistically non-significant differences in the study variables were observed between the isoflurane and sevoflurane groups. Blood gases and electrolyte parameters in both groups were unchanged. Intraocular pressure and liver enzymes levels were similar to reference values. Anesthesia protocols of study using medetomidine combined with isoflurane or sevoflurane produced minimal complications in horses. Medetomidine with sevoflurane provided deep anesthesia, and had fewer cardiopulmonary effects than medetomidine with isoflurane. (C) 2015 PVJ. All rights reservedÖğe A Comparasion of Laboratory and Cardiopulmonary Effects of Desflurane, Detomidine and Medetomidine Anaesthetic Combinations in Horses(UNIV FED RIO GRANDE DO SUL, 2017) Erol, Hanifi; Arican, MustafaBackground: Equine anesthesia morbidity and mortality rates are greater than in other domestic animals because of hypotension and hypoventilation. The important features desired in general anesthesia for horses are a rapid effect, rapid emergence and balanced anesthesia. The long duration of action of currently used anesthetic agents cause various complications in horses. The aim of the present study was to compare the clinical effects of combination of the anesthetics desflurane, detomidine and medetomidine in horses. Materials, Methods & Results: Eight healthy mixed-breed horses (four males and four females) with weighing 275 +/- 56 kg [mean +/- standard deviation (SD)] and aged 6.8 +/- 5 years [(mean +/- SD)] were used for this study. The horses were placed into one of four groups: group I (detomidine-desflurane), group II (detomidine-desflurane-atipamezole), group III (medetomidine-desflurane), or group IV (medetomidine-desflurane-atipamezole). Horses were rested for 15 days before each group starts to study. Intravenous detomidine (25 mu g/kg) was used for premedication in groups I and II, and intravenous medetomidine (7 mu g/kg) was used for premedication in groups III and IV. Ketamine hydrocholoride (2 mg/kg) and midazolam (0.03 mg/kg) were intravenously administered in the same syringe to induce anesthesia. After induction of anesthesia, horses were placed in the left lateral recumbent position, and the trachea was intubated with a cuffed endotracheal tube with an internal diameter of 28 mm. The endotracheal tube was attached to a large animal circle breathing system anesthesia machine, and anesthesia was maintained with desflurane for 90 min. The initial dosage of desflurane was 14% + 4 LO2/min, and was reduced by 2% every 10 min over the first 30 min of anesthesia. After 30 min, the desflurane dose was changed to 8% + 4 L, which was maintained until the end of anesthesia (90 min). After 90 min, the administration of desflurane was discontinued, and all animals were supported by O-2, with groups II and IV receiving 0.06 mg/kg atipamezole in addition to oxygen. Anaesthetic action times, hematological parameters, blood gas levels, electrolyte levels, biochemical values, electrocardiography values and end-tidal carbon dioxide volume were measured before, during, at the end of, and 24 h after anesthesia. Discussion: In this study, medetomidine (7 mu g/kg) and detomidine (25 mu g/kg) were intravenously administered, which was adequate and suitable for sedating horses. At the end of anesthesia, 0.06 mg/kg atipamezole was intravenously administered in groups II and IV. However, atipamezole did not affect the clinical parameters. Stress, excitement, fear, catecholamine exchange in blood circulation, hyperglycemia, and hypoxia can all cause changes in venous blood parameters. These are potential reasons for the changes in venous blood parameters (i.e., WBC and Hb) observed at the beginning of and during anesthesia in the present study. During and after the anesthetic period, serum biochemical values can be different from baseline values. They are dependent on the effects of anesthetic agents. During anesthesia, the decrease and increase of biochemical values stabilize the changes in the enzyme system that develops because of the effects of anesthetic agents. In the present study, it was considered that the changes in the biochemical values aimed to stabilize the changes induced by anesthesia. Regarding the electrolyte parameters evaluated in the study, there was a statistical difference detected in Na values between 90 min after induction of anesthesia and 24 h after induction of anesthesia in group IV. However, in previous studies, the changes in Na values did not influence the cardiac pressure during general anesthesia. In our study, significant changes were not seen in any electrolyte parameters except Na, and atrioventricular block was not detected in ECG traces. Generally, decreased ETCO2 levels are evidence of lung perfusion deficiency. It depends on the effects of anesthetic agents on the cardiopulmonary, cardiovascular, and respiratory systems. In particular, the higher pressure and dose of desflurane supress respiratory system. Oxygen supplementation in general anesthesia increases respiratory rate, but a-2 agonists and ketamine-midazolam effects can eliminate the increasing respiratory rate in general anesthesia.Öğe Comparison of Thermographic Imaging and Other Diagnostic Techniques in Diagnosis of Cattle with Laminitis(UNIV FED RIO GRANDE DO SUL, 2018) Arican, Mustafa; Hatipoglu, Fatih; Erol, Hanifi; Kanat, Ozgur; Yavuz, Orhan; Parlak, Kurtulus; Koc, OsmanBackground: Lameness results in major economic losses on dairy farms. The proportion of lameness in cows are between 4-55%, the origin of 90% lameness are caused by foot diseases. Hoof abnormalities such as laminitis are major contributors to lameness. Aim of the study, compared with thermographic imaging (IRT) and radiographic, magnetic resonans (MR), computer tomography (CT), histopathological analysis on the diagnosis of laminitis. Materials, Methods & Results: Preliminary, the animals (20 Holstein-Fresian) were selected by lameness examination for evaluation of the for any obvious signs of disease. The animals were examined when rising and walking of the free stalls. Walking was very painful and clinical symptoms of general distress become present for laminitic group. The cows were scored on a 1 to 5 scale for their locomotion (1 = normal locomotion; 5 = severely lame). Thermographic examinations were performed the all animals after the routine clinical examination methods. The infrared images were taken from the dorsal view of all hooves to monitor the temperature of coronary band. All images were scanned using a hand-held portable infrared camera (Wahl, Thermal Imager HSI3000 Series), which was calibrated to ambient temperature and absorptive conditions. Incentives radiological examinations, dorso-palmar and latero-medial shooting was done for using of (Regius Model 110 Konica, Minolta) 70 kV and 30 mAs for each claws. MRI images of all isolated digits were performed at the Department of Radiology, by using Siemens Symphony Erlangen, Germany. Continuous series of transversal, sagital and dorsoplantar scan were obtained from all digit. Computer tomography (CT), isolated digits were performed at the Imaging Department of Radiology, by using Siemens Symphony Erlangen, Germany. CT scanner was used to obtain contiguous slices from the region of the proximal sesamoid bones to the toe. Anterior side (laminar and perilaminar tissues) of the claws was uncovered with electric wheel. Tissue samples were taken 10% buffered formaldehyde solution after establishing a routine laboratory procedure following the prepared paraffin blocks 5 micrometers thick sections with hematoxylineosin dye method according to the staining. It was finally examined by light microscopy. The computer soft ware of the infrared thermal camera showed increased local temperature, by 0.5-1.5 degrees C, between the normal and suspected regions for laminitic cases. Clinically, animals suspected of laminitis were showed general stiffness, lameness during walking difficulty. Examination of the claws was demonstrated of rings and plump appearance was evident in paries ungulae. The main damage was seen during trimming of the sole from no hemorrhages or discoloration of control group. The transversal MRI images provided excellent depictions of anatomical structures when compared to their corresponding pictures. Identifiable anatomic structure was labeled on the line drawings of the limb sections and on the corresponding CT images. Twenty out of 30 claws (65%) were shown laminitis statistical with histopathological examination. In histopathological examination; mononuclear cells and neutrophil granulocytes infilrations and edema, haemorrhagia, mild hyperemia in the lamellar region was remarkable in laminitic cases. Discussion: As a results, thermographic examination may have potential as a detection tool for laminitis. MR transversal images provided excellent depiction of anatomical structures and many biometric research in the bovine hoof can be easily investigated. The usefulness of IRT, MRI, CT in evaluating laminitis in the acute patient remains stil open. The use of diagnostic techniques during the initial active phase of laminitis as a means to increase the understanding of the disease and also serves as a justification for the development of an experiment involving live cows induces laminitis.Öğe Effect of Acticoat (R) and Cutinova Hydro (R) on wound healing(WILEY-BLACKWELL, 2013) Arican, Mustafa; Hatipoglu, Fatih; Uyaroglu, Aysen; Ozdemir, Ozgur; Ozkan, KadircanIn this study, the effects of the wound-covering materials, Acticoat((R)) and Cutinova Hydro((R)), on wound healing have been studied in rabbit models with open and tissue-lost wounds with full-thickness flank excisions. Rabbits were used as subjects with three groups of four rabbits each, and trial periods of 7, 14 and 21{\uns}days. Four circular wounds, of 1.5 cm diameter were made two on the right (one of them control) and two on the left (one of them control) of the dorsal sides of the abdomen. Acticoat((R)) and Cutinova Hydro((R)) were applied on the wounds with suture for a period of 21 days and one each placed on the right and left sides as control with gauze. Biopsy specimens were taken from the animals at the end of the research period to check the length of the epithelium, epithelial thickness, size of wounds, wound granulation tissue formation and histopathological evaluation for clarity. The Acticoat((R)) group showed better healing and scar formation compared to the Cutinova Hydro((R)) group by macroscopic examination. Epithelial wound length and clarity in terms of statistical difference occurred on day 21 (P <0.05); while the length of the wound epithelium decreased patency, epithelial thickness on days similar to 7, 14 and 21, showed no statistical differences (P >0.05). As a result, the Acticoat((R)) wound dressing was determined as a more reliable for the early wound healing. This study has shown the short-term clinical benefits of hydroactive, polyurethane dressings in the management of acute wounds. However, longer periods of wound healing procedure should be planned for reliable and safe results of wound dressing. It has also been concluded that microbiological analyses should be included for more robust and reliable comparisons.Öğe Effect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbits(H M P COMMUNICATIONS, 2016) Ozdemir, Ozgur; Ozkan, Kadircan; Hatipoglu, Fatih; Uyaroglu, Aysen; Arican, MustafaWound dressing materials such as asiaticoside, collagenase, and alpha-chymotrypsin are often used for effective wound healing activity. Objectives.' In this study; the effects of asiaticoside,, collagenase, and alpha-chymotrypsin were studied in rabbit models with open wounds with tissue loss and with full-thickness flank excisions for a period of 21 days, Materials and Methods. Three groups of 4 rabbits were examined during trial periods of 7, 14, and 21 days. Four circular wounds measuring 1.5 cm in diameter were made on the dorsal sides of the animals: 2 on the right and 2 the left. Asiaticoside, collagenase, and alpha-chymotrypsin were applied to wounds daily for a period of 7, 14, and 21 days, while 1 gauzed wound served as the control. All biopsy specimens were histopathologically evaluated for recovery. On day 7, microscopic review showed no differences in wound healing between groups. Results. By day 14, alpha-chyrnotrypsin showed the quickest reepithelialization (P<0.05); and by day 21 asiaticoside and collagenase (P<0.01) showed effective recovery, due to the completion of wound healing for all animals in both groups. Conclusion. Alpha-chymotrypsin is more effective than the other 2 groups for only 14 days. The effectiveness of asiaticoside and collagenase-displayed a more rapid improvement in comparison to alpha-chymotrypsin for healing open wounds with tissue loss for a period of 21 days.Öğe EVALUATION AND APPLICATION OF THE TTA-RAPID METHOD IN DOGS WITH CRANIAL CRUCIATE LIGAMENT RUPTURE(DE GRUYTER OPEN LTD, 2017) Arican, Mustafa; Parlak, Kurtulus; Sahin, HuseyinThe objective of this study intended the application of the current technique of modified tibial tuberosity advancement (TTA)-rapid method in dogs with cranial cruciate ligament rupture (CrCL) and reports on the clinical outcome and complications. The study material consisted of 17 male dogs of different breeds between the ages of 2-8 years, average weight of 32 kg with a diagnosed unilateral CCL rupture. Hudson Visual Analog Scale (HVAS)-Walking Test Rating, Canine Brief Pain Inventory (CPBI)Pain Rating) were examined, and rupture of the CCL was diagnosed based on direct radiographic examination. The pre-operative evaluation of the implant to be used in TTA-Rapid technique was determined by measuring radiographic images of the CCL in dogs. Post-operative evaluation in the 1(st), 2(nd), and at 3 month was performed by radiographic examination, gait and pain tests. Major complications were recorded in 17.6% of the cases. Fourteen (82.4%) dogs had a good to excellent outcome 3 months after surgery. Lameness and pain assessment were performed up to 15 days prior to the operation and 1, 2, and 3 months after the TTA-Rapid technique procedure.Öğe Lipid-laden aqueous humor in a cat(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2018) Arican, Mustafa; Parlak, Kurtulus; Uzunlu, Elgin OrcumThis case report describes the clinical findings in a 5 years old neutered female cat presented with sudden onset of binocular blindness with cloudy appearance in both eyes. Systematic eye examination was performed after the anamnesis. Only intraocular pressure was increased in right eye. The examination of iris was not properly due to the opacity of humor aquosus. Liver function was checked in terms of diabetes and pancreatitis. Cholesterol and triglyceride levels were increased in blood analysis. The diagnosis was hyperlipidemia and hypertriglyceridemia. Dexamethasone (0.5 mg/kg) was applied to the subconjunctivaly; dexamethasone 0.196 w/v opthalmic solution drops (6 times in a day) and low-fat diet were recommended in the continuation of the treatment. The patient was immediately responded to the treatment within 36 hours. Aqueosus humor reached clear structure in both eyes. A visual activity was improve in the eyes. Post-operatively, the case was followed for 8 months. There were no complications encountered. This report is to contribute to increased awareness regarding the some ocular complications following diet programmes. In addition, the use of steroid ophthalmic solutions along with a diet program in the treatment protocol will accelerate the healing process quickly.Öğe Matrix metalloproteinases 2 and 9 activity after intra-articular injection of autologous platelet-rich plasma for the treatment of osteoarthritis in dogs(VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2018) Arican, Mustafa; Simsek, Atilla; Parlak, Kurtulus; Atli, Kamil; Sonmez, GoncaIntra-articular injection of platelet-rich plasma offers a promising potential for treatment of osteoarthritis in dogs. Twenty dogs weighing 25 to 50 kg (mean 38 kg) with unilateral stifle osteoarthritis were used for the study. Fourteen dogs were given intra-articular platelet rich plasma treatment and 6 dogs were used as controls. Double centrifuge method was used to obtain platelet-rich plasma. Radiography and ultrasonography of the affected joint were carried out and scores for lameness severity and pain severity were assigned by the attending clinicians. Synovial fluid was collected under sterile conditions at pre-treatment and on the 1st, 3rd, 5th, 7th, 15th days, and 4, 8 and 12 weeks after treatment. Gelatin zymography and Enzyme-linked Immunosorbent Assay were used to determine the synovial fluid levels of matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9). No adverse effects associated with the injection of the platelet concentrate or saline were observed. Hudson Visual Analog Scale and Canine Brief Pain Inventory scores for all components were non-significantly different between weeks 0, 4, 12 for control dogs. Matrix metalloproteinase-9 was totally and MMP-2 was partially inhibited in the platelet-rich plasma group. In the control group, MMP-9 was partially inhibited during the first month and activation started later. Matrix metalloproteinase-2 was constant in control samples throughout the experimental period. Platelet-rich plasma is a safe and effective method for treatment of dogs with osteoarthritis, possibly more useful for early cases with mild and moderate osteoarthritis. It is suggested that plasma rich platelet should be injected several times at regular intervals instead of a single application.Öğe RESULT OF ENDOSCOPICALLY ASSISTED GASTROPEXY IN DOGS(DE GRUYTER POLAND SP ZOO, 2014) Arican, Mustafa; Parlak, Kurtulus; Ince, Mehmet Ege; Guzelbektes, HasanThe aim of this study was to investigate the use of endoscopy jointly with gastropexy in dogs as a potential mean to aid prevention and evaluation of the long-term efficiency of this procedure for gastric dilatation-volvulus. The study was performed on ten healthy adult medium- and large-breed dogs. The dogs had no abnormal finding upon physical examination and each underwent an endoscopically assisted gastropexy procedure. After surgery all dogs were in good condition. The surgical procedure was followed by x-ray and ultrasonographic examinations. The records included data for gastropexy anatomic location and length, duration of the surgical procedure and complications. The mean +/- SD gastropexy length was 3.0 +/- 0.25 cm, as determined by ultrasonography, and the mean duration of the surgical procedure was 20 +/- 5 minutes. It appears that endoscopically assisted gastropexy is a simple, fast, safe, and reliable method of performing a prophylactic gastropexy in dogs. This procedure maximizes the benefits of decreased morbidity and shorter duration of anaesthesia associated with minimally invasive surgery.Öğe A Retrospective Study of Fractures in Neonatal Calves: 181 Cases (2002-2012)(UNIV AGRICULTURE, FAC VETERINARY SCIENCE, 2014) Arican, Mustafa; Erol, Hanifi; Esin, Evren; Parlak, KurtulusThe purposes of this study were to evaluate, etiology, radiological findings, treatment management, and to look at advantages and disadvandages of intramedullary nailing results of fractures in calves. One hundered eigthy one calves with fractures were used in the study. Distribution of calves was 130 Holstein (71.8%), 29 Brown Swiss (16.0%), 18 Simmental (9.9%), and 4 Charolais (2.2%). Fracture treatment was depending on the clinical findings. Conservative fracture treatment (walking cast technique), operative treatment intramedulary nailing or plate fixation) and/or amputation of the extremity were performed. To estimate of the etiology appeared that fractures of 59 (31.5%) calves had obtained during birthing due to excessive forced and inaccurate aiding, other 122 fracture (67.4%) cases were caused after trauma and badly care. Fractures were mostly happened on the metacarpal bones (60.6%) followed by femur (14.9%), metatarsal bones (7.1%), tibia (8.8%), ulna and radius(6%) and humerus (n=6, 3.2%), Success of fracture healing depend on timing and proper selection of treatment. This study shows that intramedullary pinning fixation give a satisfactory results of calves with fracture. (C) 2013 PVJ. All rights reserved
