Effect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbits
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
H M P COMMUNICATIONS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Wound dressing materials such as asiaticoside, collagenase, and alpha-chymotrypsin are often used for effective wound healing activity. Objectives.' In this study; the effects of asiaticoside,, collagenase, and alpha-chymotrypsin were studied in rabbit models with open wounds with tissue loss and with full-thickness flank excisions for a period of 21 days, Materials and Methods. Three groups of 4 rabbits were examined during trial periods of 7, 14, and 21 days. Four circular wounds measuring 1.5 cm in diameter were made on the dorsal sides of the animals: 2 on the right and 2 the left. Asiaticoside, collagenase, and alpha-chymotrypsin were applied to wounds daily for a period of 7, 14, and 21 days, while 1 gauzed wound served as the control. All biopsy specimens were histopathologically evaluated for recovery. On day 7, microscopic review showed no differences in wound healing between groups. Results. By day 14, alpha-chyrnotrypsin showed the quickest reepithelialization (P<0.05); and by day 21 asiaticoside and collagenase (P<0.01) showed effective recovery, due to the completion of wound healing for all animals in both groups. Conclusion. Alpha-chymotrypsin is more effective than the other 2 groups for only 14 days. The effectiveness of asiaticoside and collagenase-displayed a more rapid improvement in comparison to alpha-chymotrypsin for healing open wounds with tissue loss for a period of 21 days.
Açıklama
Anahtar Kelimeler
wound healing, asiaticoside, collagenase, alpha-chymotrypsin, rabbits
Kaynak
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
28
Sayı
8
