Effect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbits

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dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorOzkan, Kadircan
dc.contributor.authorHatipoglu, Fatih
dc.contributor.authorUyaroglu, Aysen
dc.contributor.authorArican, Mustafa
dc.date.accessioned2020-03-26T19:23:42Z
dc.date.available2020-03-26T19:23:42Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWound dressing materials such as asiaticoside, collagenase, and alpha-chymotrypsin are often used for effective wound healing activity. Objectives.' In this study; the effects of asiaticoside,, collagenase, and alpha-chymotrypsin were studied in rabbit models with open wounds with tissue loss and with full-thickness flank excisions for a period of 21 days, Materials and Methods. Three groups of 4 rabbits were examined during trial periods of 7, 14, and 21 days. Four circular wounds measuring 1.5 cm in diameter were made on the dorsal sides of the animals: 2 on the right and 2 the left. Asiaticoside, collagenase, and alpha-chymotrypsin were applied to wounds daily for a period of 7, 14, and 21 days, while 1 gauzed wound served as the control. All biopsy specimens were histopathologically evaluated for recovery. On day 7, microscopic review showed no differences in wound healing between groups. Results. By day 14, alpha-chyrnotrypsin showed the quickest reepithelialization (P<0.05); and by day 21 asiaticoside and collagenase (P<0.01) showed effective recovery, due to the completion of wound healing for all animals in both groups. Conclusion. Alpha-chymotrypsin is more effective than the other 2 groups for only 14 days. The effectiveness of asiaticoside and collagenase-displayed a more rapid improvement in comparison to alpha-chymotrypsin for healing open wounds with tissue loss for a period of 21 days.en_US
dc.identifier.endpage286en_US
dc.identifier.issn1044-7946en_US
dc.identifier.issn1943-2704en_US
dc.identifier.issue8en_US
dc.identifier.pmid27560471en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33472
dc.identifier.volume28en_US
dc.identifier.wosWOS:000381651400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherH M P COMMUNICATIONSen_US
dc.relation.ispartofWOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectwound healingen_US
dc.subjectasiaticosideen_US
dc.subjectcollagenaseen_US
dc.subjectalpha-chymotrypsinen_US
dc.subjectrabbitsen_US
dc.titleEffect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbitsen_US
dc.typeArticleen_US

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