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Antioxidant, Antimicrobial Activity And Dna Protective Effect Of Mespilus Germanica (L)
(Selçuk Üniversitesi, 2023 Eylül) Taner Saraçoğlu, Hatice; Arslan, Nursena; Arslan, Emine; Zengin, Gökhan; Gülbahçe Mutlu, Elif
Aim: Medlar (M. germanica) is a durable plant which have hard fruits. In this study, it was aimed to determine the antioxidant, antimicrobial activity and DNA protective effects of both fruit and seed extracts of medlar. Method: Antioxidant capacities of extracts of medlar was determined by using the DPPH method, Folin-Ciocaltaeu method was used for total phenolic content and the antimicrobial effect of the extract against 16 bacteria was investigated. Findings: As a result of the study, the possible protective effect of medlar fruit extracts obtained at different concentrations against DNA damage was determined. In addition, it was revealed that the total phenolic contents and radical scavenging activities of the seed extracts were higher than the fruits extracts. While the medlar seed extract used in the study did not show any effect against bacteria, the fruit extract of this plant had various effects on the bacteria used. In addition, it was determined that the medlar fruit extract had a protective effect in DNA+UV, DNA+H2O2 and DNA+UV+H2O2 applications. Results: According to the results obtained, it was observed that M. germanica could provide protection against oxidative stress.