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    Amylase, glucosidase, tyrosinase, and cholinesterases inhibitory, antioxidant effects, and GC-MS analysis of wild mint (Mentha longifolia var. calliantha) essential oil: A natural remedy
    (ELSEVIER SCIENCE INC, 2018) Asghari, Behvar; Zengin, Gökhan; Bahadori, Mir Babak; Abbas-Mohammadi, Mahdi; Dinparast, Leila
    Introduction: Mint is used as a herbal tea, in food additives, and as a traditional medicine all around the world. They are popular functional foods and natural remedies. A comprehensive bioactivity evaluation was performed on wild mint essential oil to shed light on its health beneficial effects and therapeutic potential as a very popular herb. Methods: The chemical composition of essential oil of wild mint (Mentha longifolia var. calliantha (Stapf) Briq.) was determined together with its antioxidant and enzyme inhibitory potential linked to Alzheimer's disease, diabetes mellitus, and skin disorders. Six different methods were employed to examine antioxidant ability, including; DPPH, ABTS, CUPRAC, FRAP, metal chelating, and Molybdenum total antioxidant assays. Results: Findings showed that 1,8-cineol (33.5%), linalool (15.1%), menthone (12.9%), and trans-piperitone oxide (12.6%) are the main volatile compounds of the plant. The essential oil exhibited promising antiradical activity (5.8 and 9.1 mmol TEs/g oil in DPPH and ABTS assays, respectively) and reducing power (102 and 337 mmol TEs/g oil in FRAP and CUPRAC assays, respectively). Moreover, remarkable antidiabetic, anticholinesterase, and antityrosinase effects were recorded for the mint oil. Conclusion: Wild mint essential oil has valuable bioactive constituents and great potential for uses in food, pharmaceutical, and cosmeceuticals industries.
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    Functional components, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of Salvia syriaca L.
    (TAYLOR & FRANCIS INC, 2017) Bahadori, Mir Babak; Dinparast, Leila; Zengin, Gökhan; Sarikurkcu, Cengiz; Bahadori, Shahram; Asghari, Behvar; Movahhedin, Nasrin
    Antidiabetic, anti-Alzheimer, general toxicity, and antioxidant activities of Salvia syriaca were evaluated. Phytochemical composition of the essential oil and methanolic extract of the plant were identified using gas chromatography-mass spectrometry and reverse-phase high-performance liquid chromatography-diode array detector techniques, respectively. Essential oil of S. syriaca exhibited strong cytotoxicity, antioxidant, a-amylase, and a-glucosidase inhibitory activities. Gas chromatography-mass spectrometry analysis showed that spathulenol (87.4%), isospathulenol (7.6%), and bornyl acetate (2.7%) are the major compounds in essential oil. High-performance liquid chromatography analysis indicated that rutin, quercetin, apigenin, rosmarinic acid, and ferulic acid are the most abundant phenolic components. S. syriaca could be considered as a valuable source of bioactive natural compounds for functional foods, medical, and pharmaceutical applications.
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    Salvia nemorosa L.: A novel source of bioactive agents with functional connections
    (ELSEVIER SCIENCE BV, 2017) Bahadori, Mir Babak; Asghari, Behvar; Dinparast, Leila; Zengin, Gökhan; Sarıkürkcü, Cengiz; Abbas-Mohammadi, Mahdi; Bahadori, Shahram
    Salvia species are used as food and medicinal plants all around the world. In this study, chemical composition and antimicrobial, toxicity, antioxidant, and enzyme inhibitory activity of Salvia nemorosa were evaluated. Phenolic components were characterized by the HPLC-DAD and 11 components were identified, in which rosmarinic acid was detected as the major compound (7584 mu g/g extract). Sixteen volatile components were determined in both leaves and flowers essential oils. Oxygenated sesquiterpenes were the major components. Methanolic extract showed the highest total phenolic and flavonoid contents (294 mg GAE/g and 117 mg QE/g extract, respectively) and the strongest DPPH radical scavenging activity (IC50: 82 mu g/mL). Plant samples showed moderate to high aldehyde oxidase, xanthine oxidase, acetylcholinesterase, and alpha-glucosidase inhibitory activity and moderate cytotoxicity. Also, EOs exhibited great antimicrobial potential (IZ: 8.8-33.7 mm). Our findings indicated that S. nemorosa may be useful for novel applications in functional food and pharmaceutical industries. (C) 2016 Elsevier Ltd. All rights reserved.