Yazar "Aslan, Adem" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 677C > T and 1298A > C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta(Turkish Neurosurgical Soc, 2010) Eser, Betül; Coşar, Murat; Eser, Olcay; Erdoğan, Müjgan O.; Aslan, Adem; Yıldız, Handan; Boyacı, Gazi; Büyükbaş, Sadık; Solak, MustafaAIM: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. RESULTS: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the A and C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). CONCLUSION: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.Öğe The effect of aprotinin on brain ischemic-reperfusion injury after hemorrhagic shock in rats: An experimental study(LIPPINCOTT WILLIAMS & WILKINS, 2007) Eser, Cay; Kalkan, Erdal; Cosar, Murat; Buyukbas, Sadik; Avunduk, Mustafa Cihat; Aslan, Adem; Kocabas, VolkanBackground. We aimed to demonstrate the positive effects of the serine protease inhibitor aprotinin on neural ischemia-reperfusion injury and apoptosis in a rat model. Methods: There were 18 rats divided into 3 groups: group A (sham, n = 6), group B (ischemia-reperfusion, n = 6), and group C (ischemia-reperfusion + aprotinin, n = 6). The systolic blood pressure of the group B and C rats was decreased to 40% to 50% of the normal level by taking blood from the femoral vein to develop hemorrhagic shock. The blood was retained and given to the remaining group B and C rats for reperfusion 20 minutes after the procedure. In group B, isotonic solution and, in group C, aprotinin was administered to the rats 5 minutes before reperfusion. After the rats were killed, the brain tissue samples were fixed for histopathologic examination. Brain tissue superoxide dismutase, malondialdehyde, and tissue myeloperoxidase level and apoptotic cell analyses were performed in all groups. Results: Superoxide dismutase level decreased from group A to group B and increased from group B to group C (p < 0.05). Malondialdehyde and myeloperoxidase levels and apoptotic cells increased from group A to group B and decreased from group B to group C (p < 0.05). Conclusions: The results suggest that the systemic use of aprotinin in ischemic neural tissue prevents reperfusion injury and also protects the morphologic, functional, and biochemical integrity of the neural tissue.Öğe Kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures: Case report(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanThe aim of the kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures in geriatric patients is to improve the patient's quality of life. In this report we present two elderly patients who were suffering of traumatic osteoporotic vertebral compression fractures and underwent successful kyphoplasties. Percutaneous kyphoplasty method for the surgical treatment of these fractures decreases the hospitalization, morbidity and mortality in these patients.Öğe Travmaya Bağlı Osteoporotik Vertebra Çökme Kırıklarının Tedavisinde Kifoplasti Uygulaması: Olgu Sunumu(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanYaşlılarda travmaya bağlı oluşan osteoporotik vertebra çökme kırıklarının tedavisinde uygulanan kifoplasti yöntemiyle hastaların yaşam kalitesinin arttırılması amaçlanmıştır. Bu yazıda travmatik osteoporotik vertebra çökme kırığı nedeniyle başvuran ve tedavilerinde başarıyla kifoplasti ameliyatı uygulanan iki yaşlı hastanın özellikleri ve sonuçları sunuldu. Osteoporotik vertebra çökme kırıklarının cerrahi tedavisinde perkütan olarak uygulanan kifoplasti, hastaların hastanede kalış sürelerini kısaltmakta, morbidite ve mortalitesini önemli derece azaltmaktadır.Öğe Travmaya Bağlı Osteoporotik Vertebra Çökme KırıklarınınTedavisinde Kifoplasti Uygulaması: Olgu Sunumu(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanThe aim of the kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures in geriatric patients is to improve the patient's quality of life. In this report we present two elderly patients who were suffering of traumatic osteoporotic vertebral compression fractures and underwent successful kyphoplasties. Percutaneous kyphoplasty method for the surgical treatment of these fractures decreases the hospitalization, morbidity and mortality in these patients.
