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Öğe Adjuvant Carboplatin and Paclitaxel after Concurrent Cisplatin and Radiation Therapy in Patients with Locally Advanced Cervical Cancer(ELSEVIER SCIENCE INC, 2018) Yavas, G.; Yavas, C.; Sen, E.; Oner, I.; Celik, C.; Ata, O.[Abstract not Available]Öğe Amelioration of Radiation-Induced Intestinal Toxicity by Beta-Hydroxy-Beta-Methyl-Butyrate, L-Glutamine, and L-Arginie: Results of an Experimental Study(ELSEVIER SCIENCE INC, 2016) Yavas, C.; Yavas, G.; Celik, E.; Buyukyoruk, A.; Buyukyoruk, C.; Yuce, D.; Ata, O.[Abstract not Available]Öğe Dosimetric comparison of two different whole brain radiotherapy techniques in patients with brain metastases: How to decrease lens dose?(IJRR-IRANIAN JOURNAL RADIATION RES, 2014) Yavas, G.; Yavas, C.; Gul, O. V.; Acar, H.; Ata, O.Background: Palliative whole brain radiotherapy (WBRT) has been the standard treatment for brain metastases. Ionizing radiation is known to be one of the most potent cataractogenic agents. We aimed to evaluate two different radiotherapy techniques with respect to the doses received by the organs at risk (OAR) in patients with brain metastasis who undergone WBRT. Materials and Methods: Ten consecutive patients with brain metastasis were included. For each patient, two different treatment plans were created for whole brain. Helmet-field (HF) (anterior border was 2 cm posterior to lens, inferior border was the bottom of C2 vertebra) and classical technique with collimation (CT) (anterior border was defined as skin fall off, inferior border was the bottom of cranial base) were generated for all patients. Two techniques were compared with respect to the doses received by the OAR including bilateral lenses, optic nerves and eye-balls, the dose homogeneity index (DHI), and the monitor unit counts (MU) required for the treatment. Student-t test was used for statistical analysis. Results: There was no difference between two techniques in terms of both DHI (p: 0.182) and MU counts (p: 0.167). The maximum and mean doses received by the right lens, left lens and right eye-ball were significantly reduced with CT (p values for maximum doses 0.007, 0.012 and 0.010; for median doses 0.027, 0.046 and 0.002 respectively). Conclusion: CT was found to be more advantageous, with respect to the lens doses in addition the dose received by the right eye-ball during WBRT.Öğe Effect of radiation on cytokines, MMP-1 and type I collagen mRNA expressions in human gingival fibroblasts.(AMER SOC CLINICAL ONCOLOGY, 2011) Yavas, G.; Yavas, C.; Bozkurt, B.; Ata, O.; Hakki, S.[Abstract not Available]Öğe The impact of spironolactone on the lung injury induced by concomitant trastuzumab and thoracic radiotherapy(IJRR-IRANIAN JOURNAL RADIATION RES, 2019) Yavaş, Güler; Yavaş, Çağdaş; Çelik, Esin; Şen, E.; Ata, O.; Afşar, Rengin ElsürerBackground: To evaluate impact of spironolactone (S) on pulmonary toxicity of concomitant use of thoracic radiotherapy (RT) and trastuzumab (T). Materials and Methods: Eighty rats were divided into eight groups: group (G) 1 was control group; G2, G3 and G4 were RT, S and T groups; G5, G6, G7 and G8 were RT+T, T+S, RT+S and RT+T+S groups respectively. Rats were sacrificed at 6 hour, 21 and 100 day after RT and lung samples were retrieved. Results: By 100th days of RT inflammation score, lung fibrosis score and TGF- expression were significantly different within study groups (p values were 0.002, 0.001 and 0.043 respectively). Inflammation score of G8 was significantly lower than inflammation scores of G2 and G5 (p values: G2-G8=0.004, and G5-G8=0.022). Inflammation score of G2 was significantly higher than G7 (p=0.028). There were significant differences regarding to fibrosis scores between G2-G8 (p=0.015), G2-G7 (p=0.017) and G5-G8 (p=0.011). TGF-beta expression was higher in both G2 and G5 when compared to G8 (p = 0.038). Conclusion: Our results suggested that S is an effective treatment option for improving radiation-induced pulmonary fibrosis. These findings should be clarified with further preclinical and clinical studies.Öğe The Impact of Spironolactone on the Lung Injury Induced by Concomitant Trastuzumab and Thoracic Radiotherapy -- 2(ELSEVIER SCIENCE INC, 2018) Yavas, G.; Yavas, C.; Celik, E.; Sen, E.; Ata, O.; Yuce, D.; Elsurer-Afsar, R.[Abstract not Available]Öğe A novel case of quartet tumor: meningioma, angiomyolipoma, ependymoma and sarcoma: report of a case and review of the literature(IJRR-IRANIAN JOURNAL RADIATION RES, 2015) Yavas, C.; Karabagli, P.; Yavas, G.; Acar, H.; Ata, O.Multiple primary tumors in a single patient are relatively rare when four or more distinct lesions are considered. Herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade soft tissue sarcoma. There was no family history and hereditary syndrome. The genetic analysis was completely normal. To best of our knowledge, the present patient is the first case in the literature, who presented with these four types of tumors.Öğe Pancreatic adenocarcinoma in a patient with relapsed Hodgkin's lymphoma(IJRR-IRANIAN JOURNAL RADIATION RES, 2013) Yavas, G.; Araz, M.; Yavas, C.; Baba, F.; Ata, O.After curative treatment of Hodgkin's lymphoma, increased risk of certain solid tumors has been reported. To best of our knowledge this is the first report of metachronous pancreatic adenocarcinoma which developed outside the previous radiation field in a patient with relapse Hodgkin's lymphoma. Herein we present an 81-year-old female who developed pancreatic adenocarcinoma four years after the curative treatment of Hodgkin's lymphoma.Öğe The use of concurrent hormonotherapy and radiotherapy does not deteriorate radiation-induced cardiac toxicity(SAGE PUBLICATIONS LTD, 2017) Yavas, C.; Yavas, G.; Toy, H.; Ata, O.Postmenopausal patients with breast cancer have two options for adjuvant endocrine therapy, tamoxifen and aromatase inhibitors (AIs) as well as radiotherapy (RT) and chemotherapy. However, there is limited data regarding the optimal sequencing of RT and tamoxifen/AIs. Thus, we aimed to evaluate the effects of tamoxifen and AIs on radiation-induced cardiotoxicity. Eighty ovariectomized rats were divided into eight groups (G). G1 was defined as a control group; G2, G3, G4, and G5 were RT, tamoxifen, anastrozle, and letrozole groups, respectively; G6, G7, and G8 were RT plus tamoxifen, anastrozle, and letrozole groups, respectively. Drugs were started 1 week before RT and continued until the animals were killed 16 weeks after RT. The heart tissues were then dissected and examined with light microscopy to determine endocardial thickness and cardiac fibrosis. The endocardial thickness scores of both RT alone and the tamoxifen groups as well as the cardiac fibrosis score of RT alone were higher than that the control group (p < 0.05 for all). There was no difference in the endocardial thickness and cardiac fibrosis scores of the RT-only group and the RT plus hormonotherapy groups (p > 0.05 for all). Concurrent administration of RT and hormonal therapy with either tamoxifen or AIs did not further amplify radiation-induced cardiac toxicity. This issue warrants further study.
