The impact of spironolactone on the lung injury induced by concomitant trastuzumab and thoracic radiotherapy
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IJRR-IRANIAN JOURNAL RADIATION RES
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: To evaluate impact of spironolactone (S) on pulmonary toxicity of concomitant use of thoracic radiotherapy (RT) and trastuzumab (T). Materials and Methods: Eighty rats were divided into eight groups: group (G) 1 was control group; G2, G3 and G4 were RT, S and T groups; G5, G6, G7 and G8 were RT+T, T+S, RT+S and RT+T+S groups respectively. Rats were sacrificed at 6 hour, 21 and 100 day after RT and lung samples were retrieved. Results: By 100th days of RT inflammation score, lung fibrosis score and TGF- expression were significantly different within study groups (p values were 0.002, 0.001 and 0.043 respectively). Inflammation score of G8 was significantly lower than inflammation scores of G2 and G5 (p values: G2-G8=0.004, and G5-G8=0.022). Inflammation score of G2 was significantly higher than G7 (p=0.028). There were significant differences regarding to fibrosis scores between G2-G8 (p=0.015), G2-G7 (p=0.017) and G5-G8 (p=0.011). TGF-beta expression was higher in both G2 and G5 when compared to G8 (p = 0.038). Conclusion: Our results suggested that S is an effective treatment option for improving radiation-induced pulmonary fibrosis. These findings should be clarified with further preclinical and clinical studies.
Açıklama
Anahtar Kelimeler
Aldosterone, pulmonary fibrosis, radiotherapy, spironolactone, Trastuzumab
Kaynak
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
17
Sayı
1
Künye
Yavas, G., Yavas, C., Celik, E., Sen, E., Ata, O., Afsar, R. E. (2019). The Impact of Spironolactone on the Lung Injury Induced by Concomitant Trastuzumab and Thoracic Radiotherapy. International Journal of Radiation Research, 17(1), 87-95.
