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Öğe Cooling and Response to Histamine in Calf Cardiac Vein(2009) Atalik, K. E.; Kılıç, M.In the present work we studied the responses of calf cardiac vein to histamine (10-9-3x10-4M) and effects of moderate cooling (to 28 °C) on these responses with analysis of the role of endothelial mediators and K+ -ions. Concentration-response curves to histamine were isometrically recorded at 37 and 28 °C (control). The same procedure was repeated at 28°C in the presence of NG-nitro-L-arginine methyl ester (L-NAME, 10-4 M), indomethacin (10-5 M), and also in the K+-free medium. During cooling, the sensitivity, but not the maximal response, was significantly lower than 37 °C. Cooling to 28°C after treatment with L-NAME did not modify the effect of cooling, whereas treatment with indomethacin increased, significantly. Furthermore, cooling to 28 C after incubation in K+-free solution increased the sensitivity to histamine. The results of this study suggest the role of cyclooxygenase pathway and also K+ ions in the cooling-induced changes of calf cardiac vein treated with histamine.Öğe Effects of cooling on histamine-induced contractions of human umbilical artery: The role of ion channels(PROUS SCIENCE, SA, 2007) Atalik, K. E.; Kilic, M.; Nurullahqlu, Z. U.; Dogan, N.The effects of cooling (to 28 degrees C) on histamine (10(-9) - 3 x 10(-4) M)-induced contractions and the role of calcium (Ca2+), potassium (K-Ca(2+)) and sodium (Na+) channel blockers in the cooling-induced responses were investigated in the endothelium-denuded human umbilical artery. Concentration-response curves to histamine were isometrically recorded at 37 and 28 degrees C (control). The same procedure was repeated at 28 degrees C in the presence of tetraethylammonium (TEA, 10(-3) M), pilsicainide (10(-6) M), ouabain (10-6 M), caffeine (3 X 10-4 M), verapamil (10(-6) M) and also in Ca2+-free medium with ethylene glycol bis-(beta-aminoethyl ether) N,N,N-1,N-1-tetraacetic acid (EGTA). During cooling, the sensitivity, but not the maximal response, was significantly higher than 37 degrees C. Cooling to 28 degrees C after treatment with verapamil or pilsicainide decreased the sensitivity, whereas treatment with TEA and ouabain significantly increased sensitivity. Treatment with caffeine did not modify the effect of cooling. Furthermore, cooling to 28 degrees C after incubation in Ca(2+)free solution with EGTA decreased the sensitivity to histamine. The results of this study suggest the role of Ca2+, K-Ca(2+) and Na+-ion channels in the cooling-induced changes of human umbilical arteries treated with histamine. (C) 2007 Prous Science. All rights reserved.Öğe Role of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during cooling(WILEY-BLACKWELL PUBLISHING, INC, 2009) Atalik, K. E.; Kilic, M.; Dogan, N.The effects of cooling (to 28 degrees C) on the vasodilation induced by diazoxide (10(-9)-3 x 10(-4) m) on carbachol-pre-contracted calf cardiac vein and coronary artery and the role of nitric oxide in these effects were analyzed. Diazoxide produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings pre-contracted with carbachol (10(-6) m). During cooling, the pIC(50) values, but not the maximal responses, to diazoxide were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N(G)-nitro-L-arginine methyl ester (10(-4) m) did not modify the effect of temperature both in cardiac vein and coronary artery. These results suggest that cooling-induced changes of diazoxide in calf cardiac vein and coronary artery are independent of nitric oxide.Öğe Vasoprotection by melatonin and quercetin in rats treated with cisplatin(NATL INST SCIENCE COMMUNICATION-NISCAIR, 2010) Atalik, K. E.; Keles, B.; Uyar, Y.; Dundar, M. A.; Oz, M.; Esen, H. H.Cisplatin-based chemotherapy has a variety of vascular side effects. The aim of the present study was to evaluate the beneficial effect of melatonin and cisplatin on the alterations in vascular reactivity and structure of cisplatin-treated rats. Phenylephrine (PHE) and KCI-caused concentration-dependent contractions of rat aorta. Pretreatment with cisplatin increased the sensitivity but not the max response to PHE and KCl. In rats treated with melatonin or quercetin before cisplatin, the EC(50) values, but not the maximal response to both agents were significantly higher than cisplatin-treated group. Compared to the control group, cisplatin-treatment significantly reduced the luminal area of the aorta. In melatonin and quercetin-treated aortas the luminal area values were significantly higher than cisplatin-treated group. The results demonstrate for the first time that melatonin and quercetin treatment may protect the aorta in cisplatin-based chemotherapy.
