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    A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF)
    (Gulhane Medical School, University of Health Sciences, 2015) Tunalı, Mustafa; Özdemir, Hakan; Küçükodacı, Zafer; Ezirganlı, Şeref; Barış, Emre; Akman, Serhan; Atay, Arzu
    In our previous studies, we developed a novel platelet-rich product that we called titaniumprepared platelet-rich fibrin (T-PRF). T-PRF is based on the hypothesis that titanium may be more effective at activating platelets than the silica activators used with glass tubes in Chouckroun's platelet-rich fibrin (PRF). This study aimed to assess the effects of T-PRF on bone augmentation in a rabbit calvaria model. Twenty-four adult male New Zealand rabbits were used in the study. T-PRF alone, inorganic bovine bone (ABB), and T-PRF + ABB were used in the experimental groups. No material was used in the control group. Half of the animals were sacrificed after one month, and the remaining animals were sacrificed 3 months later. A histomorphometric evaluation was performed to compare new bone formation among the groups. More new bone areas were determined in the T-PRF group than the other three groups. While less new bone formation was observed than in the T-PRF group, more new bone formation occurred in the ABB and T-PRF + ABB groups when compared to the control group. Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation. © Gülhane Askeri Tip Akademisi 2015.
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    Stress analysis of effects of nonrigid connectors on fixed partial dentures with pier abutments
    (MOSBY-ELSEVIER, 2008) Oruc, Selcuk; Eraslan, Oguz; Tukay, H. Alper; Atay, Arzu
    Statement of problem. In some patients, the pattern of missing teeth may require the use of a fixed partial denture (FPD) with an intermediate pier abutment. Information is needed regarding the blomechanical behavior and the position of a nonrigid connector for this treatment option. Purpose. The purpose of this study was to evaluate, by means of finite element method (FEM), the effects of rigid and nonrigid design types on stress distribution for 5-unit FPDs with pier abutments. Material and methods. A 3-dimensional cross-section FEM model (SAP 2000) simulating a 5-unit metal ceramic FPD with a pier abutment with rigid or nonrigid designs (connector location at the mesial region of the second molar, at the distal region of the second premolar, at the mesial region of the second premolar, and at the distal region of the canine) was developed. In the model, the canine, second premolar, and second molar served as abutments. A supporting periodontal ligament and alveolar bone (cortical and trabecular) were modeled. A 50-N static vertical occlusal load was applied on the cusp of each abutment to calculate the stress distributions. Three different types of load were evaluated: loading of all cusps to simulate maximum, centric occlusion contacts, loading of the canine to simulate a single anterior contact, and loading of the second molar to simulate a posterior contact. Results. The analysis of the von Mises stress values revealed that maximum stress concentrations were located at the load areas for all models. Also, for all models, the highest stress values were located at connectors and cervical regions of abutment teeth, especially at the pier abutment. Conclusions. The area of maximum stress concentration at the pier abutment was decreased by the use of a nonrigid connector at the distal region of the second premolar.