A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF)
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Gulhane Medical School, University of Health Sciences
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
In our previous studies, we developed a novel platelet-rich product that we called titaniumprepared platelet-rich fibrin (T-PRF). T-PRF is based on the hypothesis that titanium may be more effective at activating platelets than the silica activators used with glass tubes in Chouckroun's platelet-rich fibrin (PRF). This study aimed to assess the effects of T-PRF on bone augmentation in a rabbit calvaria model. Twenty-four adult male New Zealand rabbits were used in the study. T-PRF alone, inorganic bovine bone (ABB), and T-PRF + ABB were used in the experimental groups. No material was used in the control group. Half of the animals were sacrificed after one month, and the remaining animals were sacrificed 3 months later. A histomorphometric evaluation was performed to compare new bone formation among the groups. More new bone areas were determined in the T-PRF group than the other three groups. While less new bone formation was observed than in the T-PRF group, more new bone formation occurred in the ABB and T-PRF + ABB groups when compared to the control group. Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation. © Gülhane Askeri Tip Akademisi 2015.
Description
Keywords
Biomaterial(s), Guided bone regeneration, Regenerative medicine, T-PRF, Tissue engineering
Journal or Series
Gulhane Medical Journal
WoS Q Value
Scopus Q Value
Q4
Volume
57
Issue
2
