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    Anti-inflammatory activity of sesquiterpene lactones from Chrysophthalmum montanum (DC.) Boiss
    (ACG PUBLICATIONS, 2020) Ayaz, Fatma; Akkol, Esra Küpeli; Gören, Nezhun; Çalış, İhsan; Dereli, F. Tuğçe Gürağaç; Duman, Hayri; Choudhary, Muhammad Iqbal; Küçükboyacı, Nurgün
    The aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) is traditionally used for wound healing, as well as for the treatment of common cold, sinusitis, and other inflammatory diseases. The objectives of this study were to identify potential anti-inflammatory effects of the methanol extract, and its different polarity subextracts (n-hexane, chloroform, n-butanol, and remaining aqueous), and guaianolide-type sesquiterpene lactones [6 alpha-acetoxy-4 alpha-hydroxy-1 beta H-guaia-9.11(13)-dien-12.8 alpha-olide (1), 6 alpha-acetoxy-4 alpha-hydroxy -9 beta.10 beta-epoxy- 1 beta H-guaia-11 (13)-en-12 .8 alpha-olide (2), 4 alpha ,6 alpha-dihydroxy -1 beta,5 alpha,7 alpha H-guaia-9(10),11 (13)-dien-12,8 alpha-olide (3), and (4 alpha,5 alpha,8 beta,10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4)] from the aerial parts of C. montanum. In order to evaluate the anti-inflammatory activity of C. montanum, carrageenan- and PGE(2) induced hind paw edema, and acetic acid-induced increase in capillary permeability mice models were used. The methanol extract, the chloroform subextract, and compounds 3, and 4 were shown to possess anti-inflammatory activity in in vivo models at 100 mg/kg dose. The results provide a biological, and phytochemical basis for the traditional use of C. montanum aerial parts for inflammatory conditions in Turkish folk medicine.
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    An Approximate Solution of Burgers Equation by Differential Transform Method
    (2004) Ayaz, Fatma; Oturanç, Galip
    In this paper, we investigate some applications of differential transform method for solving the linear and nonlinear partial differential equations with appropriate initial and boundary conditions. In order to test and comparison of the approximate solutions obtained from differential transform method where we have studied two test problems. In the first problem, a closed form solution of the heat equation, which can be obtained from Burgers' equation by omitting the nonlinear term in it, have been found easily. In the second problem, an approximate solution to the Burgers' equation under appropriate conditions has been found for only the small values of t (time variable) and viscosity, &#957;. For decreasing viscosity, which is difficult task in the solution, it has seen that no significant difference in the solution for 0<t<0.005. The results have showed that the method can easily be applied both linear and nonlinear partial differential equations.
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    Fatty acid composition analysis of some apiaceae plants using gas chromatography-flame ionization detector (GC-FID)
    (Selçuk Üniversitesi, 01.10.2024) Eruygur, Nuraniye; Ayaz, Fatma; Bağcı, Yavuz; Bakır, Muhammed Raşit; Kara, Hüseyin
    Background/aim: The Apiaceae family, also referred to as the parsley or carrot family, comprises a diverse group of plants with significant ecological and economic importance. The fundamental building blocks of plant lipids, fatty acids are involved in a number of critical biological functions. Flame ionization detection in gas chromatography (GC-FID) is a potent analytical method widely used for the qualitative and quantitative analysis of fatty acid composition in plant samples. Materials and methods: In this study, we investigated the fatty acid profiles of several Apiaceae plants using GC-FID to elucidate their lipid composition and potential applications. Results: A wide spectrum of fatty acids was confirmed, ranging from C6:0 to C22:6. Astrodaucus orientalis leaf and fruit were found rich in palmitic acid (C16:0; 35.96% and 37.65%, respectively). Ferulago asparagifolia was determined as the richest sample in terms of poly-unsaturated fatty acids such as linoleic acid (C18:2 cis, 25.65%), alpha linoleic acid (C18:3n3, 7.42%) and eicosadienoic acid (C20:2, 32.66%). Ferulago syriaca ethanol and hexane extracts contained considerable amount of oleic acid (C 18:1 n9, 40. 37% and 49.19%, respectively). Conclusion: Our review of the literature revealed that no prior reports have been made about the fatty acid compositions of Astrodaucus orientalis, Ferulago asparagifolia and Ferulago syriaca. As a result, the information provided here may be the first to describe the fatty acid contents of these species. Exploring the lipid profiles of these plants can enhance their potential applications in the food, pharmaceutical, and cosmetic industries.
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    Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr
    (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018) Ayaz, Fatma; Kucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Background: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bioassays such as cytotoxicity on brine shrimps, phytotoxicity against Lemna minor and insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The n-hexane and chloroform fractions showed significant phytotoxic activity (100 % growth inhibition) at 1000 mu g/ml against L. minor. The brine shrimp lethality test revealed that the chloroform and remaining water fractions of C. dichotomum have moderate and positive lethality with LD50 values of 169.48 and 46.26 mu g/mL, respectively. In addition, the chloroform and n-butanol fractions had low and moderate insecticidal activity with 20 and 40 % of mortality against Tribolium castaneum, respectively. Conclusion: This study demonstrates that C. dichotomum consists of bioactive constituents responsible for phytotoxicity, cytotoxicity on brine shrimps and insecticidal activity.
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    Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr.
    (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018) Ayaz, Fatma; Mucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Background: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bioassays such as cytotoxicity on brine shrimps, phytotoxicity against Lemna minor and insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The n-hexane and chloroform fractions showed significant phytotoxic activity (100 % growth inhibition) at 1000 mu g/ml against L. minor. The brine shrimp lethality test revealed that the chloroform and remaining water fractions of C. dichotomum have moderate and positive lethality with LD50 values of 169.48 and 46.26 mu g/mL, respectively. In addition, the chloroform and n-butanol fractions had low and moderate insecticidal activity with 20 and 40 % of mortality against Tribolium castaneum, respectively. Conclusion: This study demonstrates that C. dichotomum consists of bioactive constituents responsible for phytotoxicity, cytotoxicity on brine shrimps and insecticidal activity.
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    Phytotoxicity, toxicity on brine shrimp and ınsecticidal effect of chrysophthalmum gueneri aytac & anderb. growing in Turkey
    (Türkish Pharmacists Assoc, 2018) Ayaz, Fatma; Kucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Objectives: The aim of this study was to investigate the probable toxicity on brine shrimp, phytotoxicity, and insecticidal activity of Chrysophthalmum gueneri Aytac & Anderb. Materials and Methods: The MeOH (80%) extract obtained from the whole plant of C. gueneri was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform, and n-butanol. The MeOH (80%) extract and all fractions of C. gueneri were evaluated for their biologic activities using in vitro screening bioassays such as brine shrimp lethality test and phytotoxicity against Lemna minor, as well as insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The findings showed that the n-hexane and chloroform fractions of the plant had significant phytotoxic activities with 100% growth inhibition (GI) at 1000 mu g/mL against L. minor. Moreover, the MeOH (80%) extract (53% GI) and n-butanol fraction (46.6% GI) of the plant had moderate phytotoxic activities at 1000 mu g/mL. Otherwise, no samples had toxicity on the brine shrimps. In addition, the remaining water fraction had low insecticidal activity with 20% mortality against T. castaneum. Conclusion: Our results show that the n-hexane and chloroform fractions of C. gueneri had potential phytotoxic effects.
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    Solution of linear and nonlinear heat equations by differential transform method
    (Selcuk University Research Center of Applied Mathematics, 2007-01-08) Ayaz, Fatma; Kangalgil, Figen
    The differential transform method is one of the approximate methods which can be easily applied to many linear and nonlinear problems and is capable of reducing the size of computational work. Exact solutions can also be achieved by the known forms of the series solutions. In this paper, we present the definition and operation of the two-dimensional differential transform and investigate the particular exact solutions of linear and nonlinear heat equations that usually arise in mathematical biology by two-dimensional differential transform method. The results of the present method are compared very well with those obtained by decomposition method.