Anti-inflammatory activity of sesquiterpene lactones from Chrysophthalmum montanum (DC.) Boiss
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACG PUBLICATIONS
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) is traditionally used for wound healing, as well as for the treatment of common cold, sinusitis, and other inflammatory diseases. The objectives of this study were to identify potential anti-inflammatory effects of the methanol extract, and its different polarity subextracts (n-hexane, chloroform, n-butanol, and remaining aqueous), and guaianolide-type sesquiterpene lactones [6 alpha-acetoxy-4 alpha-hydroxy-1 beta H-guaia-9.11(13)-dien-12.8 alpha-olide (1), 6 alpha-acetoxy-4 alpha-hydroxy -9 beta.10 beta-epoxy- 1 beta H-guaia-11 (13)-en-12 .8 alpha-olide (2), 4 alpha ,6 alpha-dihydroxy -1 beta,5 alpha,7 alpha H-guaia-9(10),11 (13)-dien-12,8 alpha-olide (3), and (4 alpha,5 alpha,8 beta,10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4)] from the aerial parts of C. montanum. In order to evaluate the anti-inflammatory activity of C. montanum, carrageenan- and PGE(2) induced hind paw edema, and acetic acid-induced increase in capillary permeability mice models were used. The methanol extract, the chloroform subextract, and compounds 3, and 4 were shown to possess anti-inflammatory activity in in vivo models at 100 mg/kg dose. The results provide a biological, and phytochemical basis for the traditional use of C. montanum aerial parts for inflammatory conditions in Turkish folk medicine.
Açıklama
Anahtar Kelimeler
Asteraceae, Chrysophthalmum montanum, sesquiterpene lactones, anti-inflammatory, carrageenan, prostaglandins
Kaynak
RECORDS OF NATURAL PRODUCTS
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
14
Sayı
1
Künye
Ayaz, F., Akkol, E. K., Gören, N., Çalış, İ., Dereli, F. T. G., Duman, H., Choudhary, M. I., Küçükboyacı, N. (2020). Anti-inflammatory Activity of Sesquiterpene Lactones from Chrysophthalmum montanum (DC.) Boiss. Records of Natural Products, 14(1), 48-56.
