Anti-inflammatory activity of sesquiterpene lactones from Chrysophthalmum montanum (DC.) Boiss

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dc.authorid0000-0003-3994-6576
dc.authorid0000-0002-5829-7869
dc.authorid0000-0002-7207-3167
dc.authorid0000-0001-5489-3420
dc.authorid0000-0002-7554-733X
dc.authorid0000-0003-2795-9791
dc.authorid0000-0001-5356-3585
dc.authorid0000-0001-5489-3367
dc.contributor.authorAyaz, Fatma
dc.contributor.authorAkkol, Esra Küpeli
dc.contributor.authorGören, Nezhun
dc.contributor.authorÇalış, İhsan
dc.contributor.authorDereli, F. Tuğçe Gürağaç
dc.contributor.authorDuman, Hayri
dc.contributor.authorChoudhary, Muhammad Iqbal
dc.contributor.authorKüçükboyacı, Nurgün
dc.date.accessioned2020-03-26T20:20:07Z
dc.date.available2020-03-26T20:20:07Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractThe aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) is traditionally used for wound healing, as well as for the treatment of common cold, sinusitis, and other inflammatory diseases. The objectives of this study were to identify potential anti-inflammatory effects of the methanol extract, and its different polarity subextracts (n-hexane, chloroform, n-butanol, and remaining aqueous), and guaianolide-type sesquiterpene lactones [6 alpha-acetoxy-4 alpha-hydroxy-1 beta H-guaia-9.11(13)-dien-12.8 alpha-olide (1), 6 alpha-acetoxy-4 alpha-hydroxy -9 beta.10 beta-epoxy- 1 beta H-guaia-11 (13)-en-12 .8 alpha-olide (2), 4 alpha ,6 alpha-dihydroxy -1 beta,5 alpha,7 alpha H-guaia-9(10),11 (13)-dien-12,8 alpha-olide (3), and (4 alpha,5 alpha,8 beta,10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4)] from the aerial parts of C. montanum. In order to evaluate the anti-inflammatory activity of C. montanum, carrageenan- and PGE(2) induced hind paw edema, and acetic acid-induced increase in capillary permeability mice models were used. The methanol extract, the chloroform subextract, and compounds 3, and 4 were shown to possess anti-inflammatory activity in in vivo models at 100 mg/kg dose. The results provide a biological, and phytochemical basis for the traditional use of C. montanum aerial parts for inflammatory conditions in Turkish folk medicine.en_US
dc.description.sponsorshipGazi University Research FoundationGazi University [02/2017-11]en_US
dc.description.sponsorshipThe authors would like to acknowledge the support of Gazi University Research Foundation [grant number 02/2017-11].en_US
dc.identifier.citationAyaz, F., Akkol, E. K., Gören, N., Çalış, İ., Dereli, F. T. G., Duman, H., Choudhary, M. I., Küçükboyacı, N. (2020). Anti-inflammatory Activity of Sesquiterpene Lactones from Chrysophthalmum montanum (DC.) Boiss. Records of Natural Products, 14(1), 48-56.
dc.identifier.doi10.25135/rnp.135.18.11.1074en_US
dc.identifier.endpage56en_US
dc.identifier.issn1307-6167en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://dx.doi.org/10.25135/rnp.135.18.11.1074
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38507
dc.identifier.volume14en_US
dc.identifier.wosWOS:000485964000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAyaz, Fatma.
dc.language.isoenen_US
dc.publisherACG PUBLICATIONSen_US
dc.relation.ispartofRECORDS OF NATURAL PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsteraceaeen_US
dc.subjectChrysophthalmum montanumen_US
dc.subjectsesquiterpene lactonesen_US
dc.subjectanti-inflammatoryen_US
dc.subjectcarrageenanen_US
dc.subjectprostaglandinsen_US
dc.titleAnti-inflammatory activity of sesquiterpene lactones from Chrysophthalmum montanum (DC.) Boissen_US
dc.typeArticleen_US

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