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Öğe Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: Effects of magnesium supplementation(HUMANA PRESS INC, 2008) Cinar, Vedat; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Polat, YahyaThe effects of a 1-month exercise program and magnesium supplementation on the adrenocorticotropic hormone and cortisol levels were studied in young tae-kwon-do and sedentary subjects both at rest and exhaustion. The hormone levels were compared before and after supplementation with 10 mg of magnesium (as magnesium sulfate) per kilogram of body weight. Both exercise and magnesium supplements caused significant increases of the adrenocorticotropic hormone (p < 0.05). The cortisol levels were increased in training subjects receiving supplements (p < 0.05) but not so in subjects that either trained or received magnesium supplements in an independent manner. The cortisol levels measured in resting individuals were higher in the supplemented and non-supplemented athletes than those in sedentary subjects (p < 0.05). The results of this study show that exercise and/or magnesium supplementation causes a rise of the adrenocorticotropic hormone, whereas cortisol is increased only as a result of combined exhaustion and magnesium supplements.Öğe Both hypothyroidism and hyperthyroidism increase plasma irisin levels in rats(WALTER DE GRUYTER GMBH, 2018) Atici, Emine; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, EsmaBackground: A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim: The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods: The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3. Hypothyroidism (PTU 2 weeks) + L-thyroxin (1.5 mg/kg/day for 1 week); 4. Hyperthyroidism induced in rats by 3-week thyroxin (0.3 mg/kg/day); 5. Hyperthyroidism + PTU. At the end of the study, blood samples were collected to quantify free triiodothyronine (FT3), free triiodothyronine (FT4) and irisin levels. Results: FT3 and FT4 levels were reduced in hypothyroidism and were significantly elevated in hyperthyroidism (p < 0.001). Irisin values, on the other hand, were found to be elevated in both hypothyroidism and hyperthyroidism groups (p < 0.001). Conclusion: The results of the study suggest that irisin values increase in thyroid dysfunction, hypo-and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal.Öğe Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients(HUMANA PRESS INC, 2017) Baltaci, Abdulkerim Kasim; Dundar, Tugrul Kadir; Aksoy, Faruk; Mogulkoc, RasimThe present study aims to examine the changes in the serum levels of trace elements before and after the operation in thyroid cancer patients. The study registered 50 individuals, of whom 25 were female and 25 were male. The patients were allocated to four groups: group 1: male thyroid cancer patients group (n = 15), group 2: female thyroid cancer patients group (n = 15), group 3: male control group (n = 10), group 4: female control group (n = 10). The subjects in groups 1 and 2 were the patients who were post-operatively diagnosed with a pathological malignancy in the thyroid tissue samples. Blood samples were collected from all subjects before the operation, immediately after the operation, and on the post-operative day 15. Additionally, thyroid tissue samples were taken from all subjects post-operatively. Some elements in the blood and tissue samples were determined using the atomic emission method. Zinc and selenium levels of groups 1 and 2 in the pre- and post-operative measurements were significantly lower than those in the control groups (p < 0.05), but were higher in the thyroid tissue (p < 0.05). Serum zinc and selenium levels measured in the subjects on the post-operative day 15 were similar to those measured in the controls. Our study show that changes in the serum and thyroid tissue levels of trace elements like zinc and selenium, which play a critical role in thyroid function, might be associated with the pathogenesis of thyroid cancer.Öğe Chronic (3-Weeks) Treatment of Estrogen (17 beta-Estradiol) Enhances Working and Reference Memory in Ovariectomized Rats: Role of Acetylcholine(SPRINGER/PLENUM PUBLISHERS, 2016) Uzum, Gulay; Bahcekapili, Nesrin; Baltaci, Abdulkerim Kasim; Mogulkoc, Rasim; Ziylan, Yusuf ZiyaRecently there has been a growing interest in the effects of estrogen on cognitive functions. In this study, we aimed to examine 17 beta-estradiol treatment on working and reference memory in ovariectomized rats. We also examined the changes in the acetylcholine (ACh) levels in the brain areas associated with learning and memory. The study was performed on Sprague-Dawley type 3-month-old female rats. The rats were divided into four groups as control, ovariectomy (OVX), and OVX and estrogen treatment (10 A mu g/day i.p. 17 beta-estradiol) groups for 3 (OVX + E3) and 21 days OVX + E21). The rats were trained on eight arm radial maze task with eight arms baited to assess spatial memory, in addition four arms baited to assess both working and reference memory performances. The electron microscope images of the ACh vesicles in the frontal cortex, temporal cortex and hippocampus areas of the brain which are important regions for learning and memory were screened. Results showed that long term 17 beta-estradiol treatment has positive effects on both reference memory and working memory and that ACh vesicles increased in the examined brain areas, especially in hippocampus. Our results suggest that 3 weeks 17 beta-estradiol treatment may have an ameliorative effect on the memory through the central cholinergic system.Öğe Determination of Effective Mechanism of Melatonin in Hyperthermic Febrile Convulsion in Rats(KARGER, 2018) Aydin, Leyla; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim[Abstract not Available]Öğe The effect of 3 ', 4 '-dihydroxyflavonol on lipid peroxidation in brain ischemia-reperfusion damage in rat(WILEY-BLACKWELL, 2015) Caliskan, Merve; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, Esma; Ergene, Neyhan[Abstract not Available]Öğe The Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury(SPRINGER/PLENUM PUBLISHERS, 2016) Caliskan, Merve; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Menevse, EsmaThe aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.Öğe The effect of 3 ',4 '-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in rats(BIOINTERFACE RESEARCH APPLIED CHEMISTRY, 2018) Duman, Aysel; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Sivrikaya, AbdullahThe purpose of the present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on plasma lipid peroxidation in experimental testicular torsion-detorsion. The study involved 60 Wistar-albino type male rats weighing 250-260 gr. The experiment groups were formed as follows: 1. Control; 2. Sham-control; 3.720 degrees-4 hours torsion; 4. 720 degrees-4 hours torsion+4 hours detorsion; 5. 720 degrees-4 hours torsion+DiOHF; 6. 720 degrees-4 hours torsion+DiOHF+4 hours detorsion; 7. 720 degrees-4 hours torsion+24 hours detorsion; 8. 720 degrees-4 hours torsion+DiOHF+24 hours detorsion. The animals in the experimental groups were anesthetized after the procedures and their blood samples were taken to determine the levels of plasma glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), and erythrocyte glutathione (GSH). Among the study groups, group 5 was found to have the highest plasma glutathione peroxidase values (p<0.001). Groups 3 and 4, which were torsion and detorsion groups, had the lowest plasma GPx values (p<0.001). Plasma NO values were found be higher in groups 3 and 4 than all other groups (p<0.001). Groups 3, 4, and 7 had the highest plasma MDA levels (p<0.001). Erythrocyte GSH levels in groups 5 and 7 were significantly higher than the levels in other groups (p<0.001). The results of the study indicate that lipid peroxidation that increases in plasma during testis ischemia-reperfusion injury in rats is prevented by intra-peritoneal DiOHF administration.Öğe Effect of acute swimming exercise on lactate levels and its relation with zinc in pinealectomized rats(JOHN WILEY & SONS LTD, 2007) Baltaci, Abdulkerim Kasim; Cumraligil, Burhan; Kilic, Mehmet; Kaya, OktayIt is argued that melatonin secreted from the pineal gland regulates the levels of zinc, which is an important trace element. Decreases in zinc levels of pinealectomized rats supports this relationship. There is an increasing amount of evidence suggesting that the pineal gland can have important effects on physical activity. The objective of the present study was to explore the changes in serum lactate levels in pinealectornized rats subjected to acute swimming exercise and its relation with zinc. Forty adult male rats of Spraque Dawley strain were equally allocated to four groups. Group 1: General Control Group. Group 2: Pinealectomized Control Group. Group 3: Swimming Control Group. Group 4: Pinealectomized Swimming Group. Serum zinc, melatonin and lactate levels were determined in the blood samples collected from the animals by a decapitation method. Zinc and melatonin levels were higher in Group I than in Groups 2, 3 and 4 (p < 0.01), higher in Group 3 than in Groups 2 and 4 (p < 0.01) and higher in Group 2 than in Group 4 (p < 0.01). The highest lactate levels were found in Group 4 (p < 0.01). Lactate levels in Group 3 were higher than those in Groups I and 2 (p < 0.01), while the levels in Groups I and 2 did not differ. Pinealectomy results in a significant increase in lactate levels in rats subjected to an acute swimming exercise. This increase in lactate levels may be associated with the decrease observed in zinc levels after pinealectomy. Copyright (C) 2006 John Wiley & Sons, Ltd.Öğe The effect of different doses of zinc supplementation on serum element and lactate levels in elite volleyball athletes(UNIV SOUTH BOHEMIA, 2017) Eskici, Gunay; Gunay, Mehmet; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThe present study aims to examine the effect of different doses of zinc administration on serum element metabolism and fatigue. The study registered 20 female elite athletes. The subjects were divided into two groups in equal numbers. Group supplemented with 220 mg/day zinc sulfate. Group supplemented with 440 mg/day zinc sulfate. Athletes who were already engaged in their daily training routines were put to a 20-m shuttle run test to create fatigue before and after supplementation. Blood samples were collected from the subjects for a total of 7 times, before and after zinc supplementation and during rest and after exercise within one-week intervals over the course of the 4-week supplementation. The blood samples collected as such were analyzed to determine serum magnesium, phosphorus and calcium, zinc, iron, copper, and selenium, and plasma lactate. Both exercise and zinc supplementations significantly elevated magnesium, calcium, and iron levels for 4 weeks. Pre-supplementation exercise elevated plasma lactate levels, while zinc supplementation led to a fall in plasma lactate. The results of the present study indicate that zinc-supplementation for 4 weeks may have a positive impact on athletic performance by delaying fatigue. (C) 2016 Published by Elsevier Sp. z o.o. on behalf of Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice.Öğe EFFECT OF EXHAUSTING EXERCISE AND CALCIUM SUPPLEMENTATION ON POTASSIUM, MAGNESIUM, COPPER, ZINC AND CALCIUM LEVELS IN ATHLETES(PROFESSIONAL MEDICAL PUBLICATIONS, 2009) Cinar, Vedat; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimObjective: Present study was performed to determine four week calcium supplementation and athleticism exercise on plasma potassium, calcium, magnesium, cupper and zinc levels in resting and exhaustion. Methodology: Research was carried out on 30 healthy mate people. Group 1; Exercise, Group 2; Exercise + Calcium supplementation, Group 3; Sedentary+Calcium supplemented. Results: All elements levels increased by exhausting exercise (P<0.05). Plasma K and Ca levels increased in exercise group after supplementation (P<0.05). Ca levels increased in exercise + supplemented group (P<0.05). This increase was much more in group three (P<0.05). Plasma Cu levels increased by Ca supplementation in sedentary (P<0.05). Exhausting exercise increased Zn levels in sedentary after supplementation (P<0.05). Conclusion: The results of present study show that calcium supplementation for 4 week does not have clear affect on potassium and Mg. However, calcium levels were increased by supplementation and Cu after the supplementation. It was also exhausting exercise that caused increase in all parameters.Öğe Effect of Intraperitoneal Selenium Administration on Liver Glycogen Levels in Rats Subjected to Acute Forced Swimming(HUMANA PRESS INC, 2011) Akil, Mustafa; Bicer, Mursel; Kilic, Mehmet; Avunduk, Mustafa Cihat; Mogulkoc, Rasim; Baltaci, Abdulkerim KasimThere are a few of studies examining how selenium, which is known to reduce oxidative damage in exercise, influences glucose metabolism and exhaustion in physical activity. The present study aims to examine how selenium administration affects liver glycogen levels in rats subjected to acute swimming exercise. The study included 32 Sprague-Dawley type male rats, which were equally allocated to four groups: Group 1, general control; Group 2; selenium-supplemented control (6 mg/kg/day sodium selenite); Group 3, swimming control; Group 4, selenium-supplemented swimming (6 mg/kg/day sodium selenite). Liver tissue samples collected from the animals at the end of the study were fixed in 95% ethyl alcohol. From the tissue samples buried into paraffin, 5-A mu m cross-sections were obtained using a microtome, put on a microscope slide, and stained with PAS. Stained preparations were assessed using a Nikon Eclipse E400 light microscope. All images obtained with the light microscope were transferred to a PC and evaluated using Clemex PE 3.5 image analysis software. The highest liver glycogen levels were found in groups 1 and 2 (p < 0.05). The levels in group 4 were lower than those in groups 1 and 2 but higher than the levels in group 3 (p < 0.05). The lowest liver glycogen levels were obtained in group 3 (p < 0.05). Results of the study indicate that liver glycogen levels that decrease in acute swimming exercise can be restored by selenium administration. It can be argued that physiological doses of selenium administration can contribute to performance.Öğe Effect of Long-Term Intraperitoneal Zinc Administration on Liver Glycogen Levels in Diabetic Rats Subjected to Acute Forced Swimming(HUMANA PRESS INC, 2011) Bicer, Mursel; Gunay, Mehmet; Akil, Mustafa; Avunduk, Mustafa Cihat; Mogulkoc, Rasim; Baltaci, Abdulkerim KasimThis study aims to examine the effect of zinc administration on liver glycogen levels of rats in which diabetes was induced with streptozotocin and which were subjected to acute swimming exercise. The study was conducted on 80 adult Sprague-Dawley male rats, which were equally allocated to eight groups: group 1, general control; group 2, zinc-administrated control; group 3, zinc-administrated diabetic control; group 4, swimming control; group 5, zinc-administrated swimming; group 6, zinc-administrated diabetic swimming; group 7, diabetic swimming; group 8, diabetic control group. In order to induce diabetes, animals were injected with 40 mg/kg intraperitoneal (ip) streptozotocin. The injections were repeated in the same dose after 24 h. Animals which had blood glucose at or above 300 mg/dl 6 days after the last injections were accepted as diabetic. Zinc was administrated ip for 4 weeks as 6 mg/kg/day per rat. Hepatic tissue samples taken from the animals at the end of the study were fixed in 95% ethyl alcohol. Cross sections of 5 A mu m thickness, taken by the help of a microtome from the tissue samples buried in paraffin, were placed on a microscope slide and stained with periodic acid-Schiff and evaluated by light microscope. All microscopic images were transferred to a PC and assessed with the help of Clemex PE3.5 image analysis software. The lowest liver glycogen levels in the study were obtained in groups 3, 4, 6, 7, and 8. Liver glycogen levels in group 5 were higher than groups 3, 4, 6, 7, and 8, but lower than groups 1 and 2 (p < 0.05). Groups 1 and 2 had the highest liver glycogen levels. The results obtained from the study indicate that liver glycogen levels which dropped in acute swimming exercise were restored by zinc administration and that diabetes induced in rats prevented the protective effect of zinc.Öğe The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women(HUMANA PRESS INC, 2008) Sunar, Fusun; Gormus, Zulfikare Isik; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThe objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen+ 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen+5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.Öğe The effect of magnesium supplementation on glucose and insulin levels of Tae-kwan-do sportsmen and sedentary subjects(UNIV KARACHI, 2008) Cinar, Vedat; Polat, Yahya; Mogulkoc, Rasim; Nizamlioglu, Mustafa; Baltaci, Abdulkerim KasimThis study was performed to determine how the magnesium supplementation for a 4-week period affects the glucose and insulin levels at rest and at exhaustion in sportsmen. This is a 4 week study performed on 30 healthy male subjects varying between 18-22 ages. Subjects were separated into 3 groups. 1st group; group supplemented with magnesium, 2nd group; Magnesium supplementations +exercise group, 3rd group; training group. Glucose and insulin parameters of the groups were measured 4 times; at rest and exhaustion in the beginning of the research and at rest and exhaustion after the end of 4 weeks application period. Glucose levels in exhaustion measurements both before and after the supplementation significantly increased compared to resting levels (p<0.05). Significant difference was determined in the glucose values of 1st and 2nd groups supplemented with magnesium in comparison to their first measurements (p<0.05). Insulin values a decrease in all of the 3 groups occurred with exercise both before and after the supplementation (p<0.05). Magnesium supplementation has an important effect on glucose levels whereas it has no effect on insulin levels.Öğe Effect of magnesium supplementation on some plasma elements in athletes at rest and exhaustion(HUMANA PRESS INC, 2007) Cinar, Vedat; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Nizamlioglu, MustafaThe effects of magnesium supplementation on plasma magnesium, zinc, and copper levels were determined in young adult tae-kwon-do athletes and sedentary controls at rest and exhaustion. After a 4-week supplementation period with 10 mg/day/kg Mg, the plasma magnesium, copper, and zinc levels significantly increased in sedentary and training (90-120 min training 5 days a week) subjects when compared to nonsupplemented controls (p < 0.05).Öğe EFFECT OF NOCTURNAL EXHAUSTION EXERCISE ON THE METABOLISM OF SELECTED ELEMENTS(INST BIOLOSKA ISTRAZIVANJA SINISA STANKOVIC, 2014) Patlar, Suleyman; Gulnar, Ubeyde; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThe present study aims to examine how exercise performed until fatigue at night affects element distribution in the serum. The study examined 10 healthy sedentary males who were not actively engaged in any particular sport and whose mean age was 23.00 +/- 0.25 years, mean height 177.79 +/- 2.25 cm, and mean weight 70.70 +/- 1.63 kg. Blood samples were collected from the subjects at midnight twice: during rest before exercise and after exercise. Serum phosphorus, sodium, potassium, sulfur (mmol/L), cobalt, boron, cadmium, chrome, nickel, manganese, molybdenum, copper, iron, zinc and calcium levels (mg/L) were measured using atomic emission spectroscopy (ICP-AES). Exhaustion exercise performed at night brought about a decrease in copper levels only (p< 0.05), while elevating levels of potassium, sodium, magnesium, calcium, iron, zinc, manganese, nickel, selenium, molybdenum, chrome, cobalt, lead and cadmium (p< 0.05). The results of the study demonstrate that nighttime exercise until exhaustion significantly alters element metabolism.Öğe The Effect of Pinealectomy and Melatonin Application on Metallothionin, ZnT3 and ZIP2 Levels in Rat Brain Tissue(KARGER, 2018) Deniz, Arife; Baltaci, Saltuk Bugra; Baltaci, Abdulkerim Kasim; Mogulkoc, Rasim; Avunduk, Mustafa Cihat[Abstract not Available]Öğe The Effect of Pinealectomy and Melatonin Supplementation on Serum Melatonin, Nesfatin-1 and Ghrelin Levels in Rats(KARGER, 2018) Sonmez, Saadet; Baltaci, Abdulkerim Kasim; Baltaci, Saltuk Bugra; Mogulkoc, Rasim; Menevse, Esma[Abstract not Available]Öğe Effect of pinealectomy on homocysteine levels in ovariectomized rats(MAGHIRA & MAAS PUBLICATIONS, 2007) Oztekin, Esma; Ozturk, Bahadir; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim; Tiftik, Ali MuhtarOBJECTIVE: Hyperhomocysteinemia plays a role in obstetric and gynecological diseases and such diseases are seen as a consequence of an impaired methionine cycle. In the present study, it was aimed to determine the effect of estradiol and progesterone on homocysteine levels in pinealectomized and ovariectomized rats. MATERIALS AND METHODS: The study was carried out on 24 adult Spraque-Dawley female rats. Rats were divided into 4 groups as follows: Group 1: Sham ovariectomy group (Sham-Ovx), Group 2: Ovariectomized and sham pinealectomized group (Ovx-Sham-Px), Group 3: Ovariectomized and pinealectomized group (Ovx-Px), Group 4: Group which were supplemented with estradiol and progesterone after ovariectomy and pinealectomy (Ovx-Px-E+P). Serum homocysteine levels were determined after experimental period. RESULTS: Homocysteine levels in Group 3 were higher than those in Groups 1, 2 and 4 (p<0.05). Homocysteine levels in Groups 2 and 4 were higher than those in Group 1 (p<0.05). Homocysteine levels in Groups 2 and 4 were not different. CONCLUSION: The findings of the present study demonstrate that ovariectomy lead to increases homocysteine levels. Pinealectomy in addition to ovariectomy increases homocysteine levels. However, administration of estradiol and progesterone following pinealectomy prevents the increase in homocysteine levels in ovariectomized rats.
