The effect of 3 ',4 '-dihydroxyflavonol on plasma oxidant and antioxidant systems in testis ischemia-reperfusion injury in rats
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BIOINTERFACE RESEARCH APPLIED CHEMISTRY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The purpose of the present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on plasma lipid peroxidation in experimental testicular torsion-detorsion. The study involved 60 Wistar-albino type male rats weighing 250-260 gr. The experiment groups were formed as follows: 1. Control; 2. Sham-control; 3.720 degrees-4 hours torsion; 4. 720 degrees-4 hours torsion+4 hours detorsion; 5. 720 degrees-4 hours torsion+DiOHF; 6. 720 degrees-4 hours torsion+DiOHF+4 hours detorsion; 7. 720 degrees-4 hours torsion+24 hours detorsion; 8. 720 degrees-4 hours torsion+DiOHF+24 hours detorsion. The animals in the experimental groups were anesthetized after the procedures and their blood samples were taken to determine the levels of plasma glutathione peroxidase (GPx), nitric oxide (NO), malondialdehyde (MDA), and erythrocyte glutathione (GSH). Among the study groups, group 5 was found to have the highest plasma glutathione peroxidase values (p<0.001). Groups 3 and 4, which were torsion and detorsion groups, had the lowest plasma GPx values (p<0.001). Plasma NO values were found be higher in groups 3 and 4 than all other groups (p<0.001). Groups 3, 4, and 7 had the highest plasma MDA levels (p<0.001). Erythrocyte GSH levels in groups 5 and 7 were significantly higher than the levels in other groups (p<0.001). The results of the study indicate that lipid peroxidation that increases in plasma during testis ischemia-reperfusion injury in rats is prevented by intra-peritoneal DiOHF administration.
Açıklama
Anahtar Kelimeler
testis ischemia-reperfusion, 3 ',4 '-dihydroxyflavonol, rat
Kaynak
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
8
Sayı
4
