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Öğe Brefeldin A exerts differential effects on various phenotypes of breast cancer cell lines(WILEY-BLACKWELL, 2016) Tekin, G.; Ozturk, B.; Ozer, E. K.; Bariskaner, H.; Unlu, A.[Abstract not Available]Öğe Bupivacaine and ropivacaine: Comparative effects on nerve conduction block(PROUS SCIENCE, SAU-THOMSON REUTERS, 2007) Bariskaner, H.; Ayaz, M.; Guney, F. B.; Dalkilic, N.; Guney, O.Unlike other drugs which act in the region of the synapse, local anesthetics are agents that reversibly block the generation and conduction of nerve impulses along a nerve fiber. This study aims to investigate the comparative inhibitions of bupivacaine and ropivacaine on the frog sciatic nerve. Isolated nerves were transferred to the nerve chamber which includes Ringer's solution. The nerves were stimulated by), standard square wave pulse protocols and the responses were recorded with conventional systems. Bupivacaine (n = 8) and ropivacaine (n 8) were administered in the nerve chamber both with cumulative concentrations (10(-9) to 10(-3) M) and the effects were monitored for variable time periods (5. 10 and 15 min). Both bupivacaine and ropivacaine significantly depressed the compound action potential (CAP) parameters in a dose-dependent (p < 0.05) and reversible manner. Difference in the eftects of these two drugs was detectable only when the dose (>= 10(-5) M) and exposure time (15 min) were increased. Percent inhibitions in maximum derivatives and latency-period measurements have shown that ropivacaine is not only fast but also much more powerful in conduction block for longer and higher doses. Blipivacaine, on the other hand, is effective in the group of fibers with relatively slower conduction velocity for all the measured doses and time periods. In conclusion, ropivacaine has a sensory specific side of action, when compared with the bupivacaine. (c) 2007 Prous Science. All rights reserved.Öğe THE DUAL EFFECTS OF LEPTIN ON AORTIC RINGS WITH AND WITHOUT ENDOTHELIUM ISOLATED FROM STREPTOZOTOCIN-INDUCED DIABETIC RATS(PROUS SCIENCE, SAU-THOMSON REUTERS, 2009) Sahin, A. S.; Bariskaner, H.; Goekbel, H.; Okudan, N.The aim of this study was to examine the effects of leptin on aortic rings with and without endothelium isolated from streptozotocin (STZ)induced diabetic and control rots, and also in the presence of on inhibitor of nitric oxide synthase (NOS). Thoracic aortic rings from 5-week STZ-induced diabetic (50 mg/kg i.p.) and age-matched control Sprague-Dawley rots were mounted in isolated tissue baths. Concentration-response curves to leptin (0.1 pM-1 nM) were constructed under basal tone and after precontraction with I PM phenylephrine in the presence or absence of N-omega-nitro-L-arginine methyl ester (L-NAME, 10 mu M). Leptin caused a concentration-dependent relaxation of precontracted endothelium-intact aortic rings from control and diabetic rots. Responses to leptin in diabetic aorta were significantly increased compared to those of controls (P < 0.05). EC50 values for leptin were similar for aortic rings from diabetic and control rots (P > 0.05). L-NAME pretreatment caused complete inhibition of the relaxant responses to leptin in the control aortic rings, while it induced a reduction in these responses in the diabetic rings (P < 0.05). Leptin-induced relaxation was eliminated when the endothelium was denuded. Leptin hod no effect on the basal tone of endothelium-intact or -denuded aortic rings from control rots. In diabetic rings, leptin elicited concentration-dependent contractions (P < 0.05). Removal of the endothelium significantly increased the contractile effect of leptin on basal tone in diabetic rings (P < 0.05). The results suggest that leptin may induce vasodilatation by endothelial mechanism(s) other than nitric oxide (NO) release from the endothelium in diabetic aortic rings. On the other hand, leptin causes contractile effects on the basal tone in aorta smooth muscle isolated from STZ-induced diabetic rots. The contractile effect of leptin on basal tone may contribute to the development of hypertension in diabetes.Öğe THE EFFECT OF DEXMEDETOMIDINE AND DEXKETOPROFEN ON RAT SIATIC NERVOUS(ELSEVIER, 2015) Taylan, S. Bagci; Bariskaner, H.[Abstract not Available]Öğe The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia(COMENIUS UNIV, 2019) Oc, B.; Arun, O.; Taylan, S. B.; Oc, M.; Bariskaner, H.; Duman, A.OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10(-9), 0(-6) M) dexmedetomidine were recorded at 37 degrees C and at 28 degrees C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37 degrees C dexmedetomidine resulted in similar signifi cant concentration-dependent contractions in both E+ and E-SV strips (p < 0.05). At 37 degrees C dexmedetomidine resulted in signifi cant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E-compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E-at 37 degrees C and also E-28 degrees C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV graftsÖğe Pharmacovigilance Awareness in Healthcare Professionals(ADIS INT LTD, 2018) Karakulak, E. D. Aral; Bariskaner, H.[Abstract not Available]Öğe THE REVERSAL EFFECT OF ONDANSETRON ON LOCAL ANESTHESIA IN THE THERMAL PAIN MODEL OF RATS(ELSEVIER, 2015) Apiliogullari, S.; Ileri, Z.; Onal, O.; Taylan, S. B.; Saltali, A. O.; Bariskaner, H.; Celik, J. B.[Abstract not Available]
