The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COMENIUS UNIV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10(-9), 0(-6) M) dexmedetomidine were recorded at 37 degrees C and at 28 degrees C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37 degrees C dexmedetomidine resulted in similar signifi cant concentration-dependent contractions in both E+ and E-SV strips (p < 0.05). At 37 degrees C dexmedetomidine resulted in signifi cant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E-compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E-at 37 degrees C and also E-28 degrees C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV grafts
Açıklama
Anahtar Kelimeler
dexmedetomidine, hypothermia, normothermia, in vitro, internal mammary artery, saphenous vein
Kaynak
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
120
Sayı
5
Künye
Oc, B., Arun, O., Taylan, S. B., Oc, M., Bariskaner, H., Duman, A. (2019). The Effects Of Dexmedetomidine On Human İnternal Mammary Artery And Saphenous Vein Grafts Under Hypothermia And Normothermia. Bratıslava Medıcal Journal-Bratıslavske Lekarske Lısty, 120,(5), 380-385.
