The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia

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dc.contributor.authorOc, B.
dc.contributor.authorArun, O.
dc.contributor.authorTaylan, S. B.
dc.contributor.authorOc, M.
dc.contributor.authorBariskaner, H.
dc.contributor.authorDuman, A.
dc.date.accessioned2020-03-26T20:19:26Z
dc.date.available2020-03-26T20:19:26Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10(-9), 0(-6) M) dexmedetomidine were recorded at 37 degrees C and at 28 degrees C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37 degrees C dexmedetomidine resulted in similar signifi cant concentration-dependent contractions in both E+ and E-SV strips (p < 0.05). At 37 degrees C dexmedetomidine resulted in signifi cant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E-compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E-at 37 degrees C and also E-28 degrees C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV graftsen_US
dc.identifier.citationOc, B., Arun, O., Taylan, S. B., Oc, M., Bariskaner, H., Duman, A. (2019). The Effects Of Dexmedetomidine On Human İnternal Mammary Artery And Saphenous Vein Grafts Under Hypothermia And Normothermia. Bratıslava Medıcal Journal-Bratıslavske Lekarske Lısty, 120,(5), 380-385.
dc.identifier.doi10.4149/BLL_2019_062en_US
dc.identifier.endpage385en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue5en_US
dc.identifier.pmid31113202en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage380en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2019_062
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38269
dc.identifier.volume120en_US
dc.identifier.wosWOS:000468529200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOc, B.
dc.institutionauthorArun, O.
dc.institutionauthorOc, M.
dc.institutionauthorBariskaner, H.
dc.institutionauthorDuman, A.
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdexmedetomidineen_US
dc.subjecthypothermiaen_US
dc.subjectnormothermiaen_US
dc.subjectin vitroen_US
dc.subjectinternal mammary arteryen_US
dc.subjectsaphenous veinen_US
dc.titleThe effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermiaen_US
dc.typeArticleen_US

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