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    Chemotherapy-induced Hepatitis B virus reactivation in HbsAg positive cancer patients: a single center experience
    (HUMANA PRESS INC, 2009) Eren, Orhan Onder; Artac, Mehmet; Boruban, Melih Cem; Yavas, Ozlem; Arslan, Ugur; Basaranoglu, Metin
    Hepatitis B reactivation due to chemotherapy is a cause of serious morbidity and mortality in some of the patients with cancer. In this study, we retrospectively assessed the prevalence of hepatitis B reactivation among the patients undergoing cytotoxic chemotherapy. We investigated efficacy of lamivudine prophylaxis against hepatitis B reactivation as well.
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    Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis
    (WILEY, 2007) Demirkok, Sevtap Sipahi; Basaranoglu, Metin; Coker, Elif; Karayel, Tuncer
    Background and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger's test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P < 0.001). For patients with Tuberculin anergy (n = 364) the onset of symptoms was most frequent in spring and least frequent in autumn (P < 0.001); there was no seasonal variation among Tuberculin positive patients (n = 128). Of those patients with a Kveim test result (n = 248), the onset of symptoms was most frequent in spring and least frequent in summer (P < 0.001); there was no seasonal variation for patients with a negative Kveim results (n = 50 patients). Conclusions: The onset of the symptoms was most frequent in spring and least frequent in the second half of the year (summer or autumn) in patients with sarcoidosis, Tuberculin anergy and a positive Kveim reaction. The significance of this finding in relation to aetiology and clinical utility needs to be further assessed.
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    Symptom date is better than the endoscopic diagnosis date in seasonal variation studies in IBD
    (LIPPINCOTT WILLIAMS & WILKINS, 2006) Basaranoglu, Metin
    [Abstract not Available]
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    Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease
    (BAISHIDENG PUBLISHING GROUP INC, 2010) Basaranoglu, Metin; Kayacetin, Serra; Yilmaz, Nevin; Kayacetin, Ertugrul; Tarcin, Orhan; Sonsuz, Abdullah
    A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease. (C) 2010 Baishideng. All rights reserved.