Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BAISHIDENG PUBLISHING GROUP INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease. (C) 2010 Baishideng. All rights reserved.
Açıklama
Anahtar Kelimeler
Nonalcoholic fatty liver disease, Pathogenesis, Rat, Rodents
Kaynak
WORLD JOURNAL OF GASTROENTEROLOGY
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
16
Sayı
18
