Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease

Basit Öğe Kaydı
dc.contributor.authorBasaranoglu, Metin
dc.contributor.authorKayacetin, Serra
dc.contributor.authorYilmaz, Nevin
dc.contributor.authorKayacetin, Ertugrul
dc.contributor.authorTarcin, Orhan
dc.contributor.authorSonsuz, Abdullah
dc.date.accessioned2020-03-26T18:05:31Z
dc.date.available2020-03-26T18:05:31Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood. In the setting of excessive central adiposity, insulin resistance is the major underlying cause of fat accumulation in hepatocytes. Because of the difficulties with human trials, several animal models have been developed for this purpose mainly characterized as follows: genetically disturbed or murine fatty liver, methionine-choline deficient diet fed or murine steatohepatitis, and high-fat or sucrose diet fed models. Although these animal models have provided useful information, none of them accurately reflect genetic, metabolic and biochemical characteristics of the human disease. (C) 2010 Baishideng. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.v16.i18.2223en_US
dc.identifier.endpage2226en_US
dc.identifier.issn1007-9327en_US
dc.identifier.issn2219-2840en_US
dc.identifier.issue18en_US
dc.identifier.pmid20458758en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2223en_US
dc.identifier.urihttps://dx.doi.org/10.3748/wjg.v16.i18.2223
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25451
dc.identifier.volume16en_US
dc.identifier.wosWOS:000277696500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBAISHIDENG PUBLISHING GROUP INCen_US
dc.relation.ispartofWORLD JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNonalcoholic fatty liver diseaseen_US
dc.subjectPathogenesisen_US
dc.subjectRaten_US
dc.subjectRodentsen_US
dc.titleUnderstanding mechanisms of the pathogenesis of nonalcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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