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Öğe Effect of dietary esterified glucomannan on performance, serum biochemistry and haematology in broilers exposed to aflatoxin(CZECH ACADEMY AGRICULTURAL SCIENCES, 2005) Basmacioglu, H; Oguz, H; Ergul, M; Col, R; Birdane, YOThe amelioration of aflatoxicosis in broiler chickens was examined by feeding two concentrations of yeast component (esterified glucomannan; EG). EG, incorporated into the diet at 0.5 and 1 g/kg, was evaluated for its ability to reduce the detrimental effects of 2 mg total aflatoxin (AF; 82.72% AFB(1), 5.50% AFB(2), 10.20% AFG(1) and 1.58% AFG(2)) in diet on growing broiler chicks from 1 to 21 d of age. A total of 240 male broiler chicks (Ross-308) were divided into 6 treatment groups [control, AF, EG (0.5 g/kg), AF plus EG (0.5 g/kg), EG (1 g/kg), and AF plus EG (1 g/kg)]. Compared to the control, AF treatment significantly decreased body weight gain from week 2 onwards. AF treatment also caused significant decreases in serum total protein, albumin, total cholesterol, triglyceride, glucose, inorganic phosphorus, creatinine levels and alanine-aminotransferase (ALAT) activity but increased the aspartate-aminotransferase (ASAT) activity. Red blood cell, haematocrit, haemoglobin, thrombocyte, and lymphocyte counts and tibial crude ash levels were significantly reduced by AF treatment, while significant increases were seen in heterophil counts. The addition of EG (I g/kg) to an AF-containing diet significantly improved the adverse effects of AF on haematological parameters, total protein, albumin values and ASAT activity. EG (I g/kg) also partially improved body weight gains (59%) and the other biochemical parameters influenced by AF treatment. The addition of EG (both 0.5 and 1 g/kg) to the AF-free diet did not cause any considerable changes in the investigated values. These results clearly indicated that EG (I g/kg) addition effectively diminished the adverse effects of AF on the investigated values. Also, the higher dietary concentration of EG (I g/kg) was found more effective than the lower concentration (0.5 g/kg) against the adverse effects of AF on the variables investigated in this study.Öğe Effects of vitamin E and prednisolone on biochemical and haematological parameters in endotoxaemic New Zealand white rabbits(NATL VETERINARY RESEARCH INST, 2004) Yazar, E; Col, R; Konyalioglu, S; Birdane, YO; Elmas, M; Bas, ALEffects of prednisolone and vitamin E on biochemical and haematological values were investigated in endotoxaemic rabbits. Forty rabbits were used and divided into four equal groups. Group I served as the control group; group 2 was infused with lipopolysaccharide (LPS) for 6 h; group 3 was injected with prednisolone before LPS administration; group 4 was injected with vitamin E for 4 consecutive days before LPS administration. Serum and blood samples were collected 8 h after the onset of LPS injection. Serum myoglobin, alanine aminotransferase, gamma glutamyl transferase, amylase, total bilirubin, direct bilirubin, creatinine, blood urea nitrogen, albumin, globulin, total protein, cholesterol, total lipids, triglycerides, low density lipoprotein, very low density lipoprotein, sodium, potassium and magnesium contents were measured. Red blood cell, white blood cell, platelet counts and percentage of differential leukocyte values were determined. It was found that prednisolone and vitamin E had a protective effect in endotoxaemic shock. Prednisolone was more effective in endotoxaemia than vitamin E.Öğe Effects of vitamin E and prednisolone on some oxidative stress markers in endotoxemic rabbits(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2004) Yazar, E; Konyalioglu, S; Col, R; Birdane, YO; Bas, AL; Elmas, MEffects of prednisolone (PR) and vitamin E (VE) on oxidative stress and antioxidant systems were investigated in endotoxemic rabbits. Forty rabbits were used and divided into four equal groups. Group I served as the control group. In group II, lipopolysaccharide (LPS, 100 mug/kg/h) was infused for 6 hours, whereas rabbits of groups III and IV received prior treatments with subcutaneous injection of prednisolone (10 mg/kg) (group III) or with intraperitoneous injections of vitamin E (10 mg/kg) for 4 consecutive days (group IV). Serum, liver, heart and kidney samples were obtained at 8 hours after infusion. Malonedialdehyde (MDA), glutathione (GSH) concentrations and superoxide dismutase (SOD), catalase (CAT) activities were spectrophotometrically determined in tissues plus in serum (for MDA). LPS caused statistically significant (p<0.05) increases of MDA and antioxidants in serum and in all tissues. PR and VE significantly (p<0.05) suppressed increases of MDA, SOD, CAT and GSH. As a consequence, prednisolone and vitamin E had protective effects on oxidative stress in endotoxemic rabbits.Öğe Intraphagocytic concentrations of free and liposome encapsulated ampicillin in sheep after intravenous infusion(NATL VETERINARY RESEARCH INST, 2006) Yazar, E; Bas, AL; Yapar, K; Birdane, YO; Elmas, M; Tras, BIntraphagocytic (neutrophil and monocyte) concentrations of free and liposome encapsulated ampicillin were investigated in sheep. The ampicillin (5 mg/kg b.wt.) was administered as intravenous infusion. Blood samples were collected at 0, 10, 30, and 60 min, and 2 and 4 h after the infusion. Neutrophils and monocytes were isolated and lysed. Ampicillin concentrations were measured by high performance liquid chromatography. As results, liposome encapsulated ampicillin caused higher intracellular concentrations in neutrophils (ratio of liposome encapsulated ampicillin/free ampicillin; from 1.736 to 2.511) and monocytes (ratio of liposome encapsulated ampicillin/free ampicillin from 2.041 to 4.384) than free ampicillin. Liposome encapsulated ampicillin also existed longer time within neutrophils (2 h) and monocytes (2 h) than free ampicillin (60 min). This formulation may be beneficial in the treatment of intracellular bacterial infections.
