Intraphagocytic concentrations of free and liposome encapsulated ampicillin in sheep after intravenous infusion
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
NATL VETERINARY RESEARCH INST
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Intraphagocytic (neutrophil and monocyte) concentrations of free and liposome encapsulated ampicillin were investigated in sheep. The ampicillin (5 mg/kg b.wt.) was administered as intravenous infusion. Blood samples were collected at 0, 10, 30, and 60 min, and 2 and 4 h after the infusion. Neutrophils and monocytes were isolated and lysed. Ampicillin concentrations were measured by high performance liquid chromatography. As results, liposome encapsulated ampicillin caused higher intracellular concentrations in neutrophils (ratio of liposome encapsulated ampicillin/free ampicillin; from 1.736 to 2.511) and monocytes (ratio of liposome encapsulated ampicillin/free ampicillin from 2.041 to 4.384) than free ampicillin. Liposome encapsulated ampicillin also existed longer time within neutrophils (2 h) and monocytes (2 h) than free ampicillin (60 min). This formulation may be beneficial in the treatment of intracellular bacterial infections.
Açıklama
Anahtar Kelimeler
sheep, liposome, neutrophils, monocytes, ampicillin
Kaynak
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
50
Sayı
2
