Intraphagocytic concentrations of free and liposome encapsulated ampicillin in sheep after intravenous infusion

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dc.contributor.authorYazar, E
dc.contributor.authorBas, AL
dc.contributor.authorYapar, K
dc.contributor.authorBirdane, YO
dc.contributor.authorElmas, M
dc.contributor.authorTras, B
dc.date.accessioned2020-03-26T17:03:46Z
dc.date.available2020-03-26T17:03:46Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntraphagocytic (neutrophil and monocyte) concentrations of free and liposome encapsulated ampicillin were investigated in sheep. The ampicillin (5 mg/kg b.wt.) was administered as intravenous infusion. Blood samples were collected at 0, 10, 30, and 60 min, and 2 and 4 h after the infusion. Neutrophils and monocytes were isolated and lysed. Ampicillin concentrations were measured by high performance liquid chromatography. As results, liposome encapsulated ampicillin caused higher intracellular concentrations in neutrophils (ratio of liposome encapsulated ampicillin/free ampicillin; from 1.736 to 2.511) and monocytes (ratio of liposome encapsulated ampicillin/free ampicillin from 2.041 to 4.384) than free ampicillin. Liposome encapsulated ampicillin also existed longer time within neutrophils (2 h) and monocytes (2 h) than free ampicillin (60 min). This formulation may be beneficial in the treatment of intracellular bacterial infections.en_US
dc.identifier.endpage261en_US
dc.identifier.issn0042-4870en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage259en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20550
dc.identifier.volume50en_US
dc.identifier.wosWOS:000238699900024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNATL VETERINARY RESEARCH INSTen_US
dc.relation.ispartofBULLETIN OF THE VETERINARY INSTITUTE IN PULAWYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsheepen_US
dc.subjectliposomeen_US
dc.subjectneutrophilsen_US
dc.subjectmonocytesen_US
dc.subjectampicillinen_US
dc.titleIntraphagocytic concentrations of free and liposome encapsulated ampicillin in sheep after intravenous infusionen_US
dc.typeArticleen_US

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