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Öğe Frequency of Cytochrome 450 (CYP2C9 and CYP2C19) Genetic Polimorphisms in Patients with Colorectal Carsinoma(AKAD DOKTORLAR YAYINEVI, 2009) Buyukdogan, Murat; Boruban, M. Cem; Artac, Mehmet; Demirel, SennurColorectal cancers are important health problems particularly in developed countries, are multifactorial diseases developing by the effects of both genetic and environmental factors. In this case-control study, we evaluated the relationship between colorectal carcinoma and gene polymorphizms of CYP2C9 and CYP2C19 which are the members of CYP2C subfamily playing important roles in the metabolism of endogenous and exogenous compounds, and also assessed other possible relations with carcinogens and drugs as well as many other risk factors such as smoking, alcohol, family history of cancer and asbestos exposure. Eighty-five patients histopathologically diagnosed with colorectal carcinoma admitted to Departments of Medical Oncology and Surgery at Meram Medical Faculty and eighty-five healhty volunteers, who have no family history of cancer, were included in this study. Heterozygote and mutant genotypes of CYP2C9 and CYP2C19 genes were determined by CYP2C9*2,CYP2C9*3 and CYP2C19*2,CYP2C19*3 Mutation Detection Kits by Light Cycler Real Time Polymerase Chain Reaction. Results were statistically compared in these case-control subjects and odds ratios were used. There were no significant differences between patients with colorectal carcinoma and control groups. However, asbestos exposure ratio in patients with colorectal carcinoma was significantly higher (p < 0.05) than control subjects. Therefore, asbestos exposure may be considered as a risk factor for colorectal carcinoma.Öğe Kolorektal Kanserli Hastalarda Sitokrom P450 (CYP2C9 ve CYP2C19) Genetik Polimorfizm Sıklığı(2009) Büyükdoğan, Murat; Boruban, M. Cem; Artaç, Mehmet; Demirel, SennurÖzellikle gelişmiş ülkelerin önemli sağlık sorunlarından biri olan kolorektal kanserler, genetik ve çevresel faktörlerin katkılarıyla gelişen multifaktöriyel bir hastalıktır. Bu vaka kontrol çalışmasında kolorektal karsinoma ile CYP2C2 alt gurubunun bir üyesi olan endojen ve eksojen maddelerin karsinojenlerin ve ilaçların metabolizmasında önemli rol alan CYP2C9 ve CYP2C19 gen polimorfizmini ve aynı zamanda sigara, alkol, ailede kanser hikayesi, asbestoz maruziyeti gibi risk faktörlerini araştırdık. Çalışmaya ailesinde kanser hikayesi olmayan 85 sağlıklı gönüllü ile Meram Tıp Fakültesi Tıbbi Onkoloji ve Genel Cerrahi kliniklerine başvuran klinik ve histopatolojik olarak çoğunluğu adenokarsinom olan kolorektal kanserli 85 hasta alındı. CYP2C9 ve CYP2C19 genlerinin heterozigot ve mutant genotiplerini belirlemek için CYP2C9*2, CYP2C9*3 ve CYP2C19*2, CYP2C19*3 mutasyon saptama kitleri Light Cycler Real Time Polymerase Chain Reaction ile kullanıldı. Sonuçlar vaka ve kontrol guruplarında istatistiksel olarak karşılaştırıldı ve hesaplanan odds oranları kullanıldı. Kolorektal karsinomdaki risk faktörleri ve CYP2C9*2, CYP2C9*3 ve CYP2C19*2, CYP2C19*3 genlerinin polimorfik genotip sıklıklarının araştırıldığı bu vaka kontrol çalışmasında; kolorektal kanserli hastalar ve kontrol gurubu arasında anlamlı fark saptanamadı. (p > 0.05). Kolorektal kanserli hastalarda beyaz toprağa maruz kalanların oranı anlamlı oranda (p < 0.05) yüksek bulundu ve beyaz toprağın kolorektal kanser için bir risk faktörü olabileceği düşünüldü.Öğe The role of thrombomodulin in the increased tendency of hypercoagulability in patients treated with cisplatin based chemotherapy(AKAD DOKTORLAR YAYINEVI, 2008) Boruban, M. Cem; Onur, HandanOne of the reason why chemotherapeutics cause increased intencity to coagulation may be the endotelial damage. The exact mechanism is not known clearly. Trombomodulin is an important modulater of inravascular coagulation and is available on many of the endotelial, tumors. In this study the effect of F-VIII, vWF other coagulation factors and thrombomoduline in the increased coagulation due to vasculary toxicity and endothelial damage after cisplatin administration were evalutaed. Venous blood samples were taken from the patients before treatment and between 12 and 24 hours after treatment. PT, aPTT, TT, fibrinojen, D-Dimer, F-VIII and thrombomodulin levels were measured. TM levels before and after chemotherapy were measured in 27 of 28 patients. Mean TM level before treatment (TMBT) was 47.7 +/- 24.8 ng/ml (22-130 ng/ml) and mean TM level after treatment (TMAT) was 39.7 +/- 19.5 ng/ml (18-96 ng/ml). The difference was not significant. The diffrence of pre and post treatment levels of TT (P=0.02) and fibrinogen (P=0.005) were significant. The researches with more patients included, may reveal TM level as a sign of endothelial toxicity. The expacted changes in the parameters after treatment were not significant as thought to be related with the inadequate number of patients.Öğe Well-Differentiated Neuroendocrine Carcinoma of the Extrahepatic Biliary Duct(MODESTUM LTD, 2015) Koksal, Hande; Ugras, N. Serdar; Uysal, Bulent; Boruban, M. CemExtrahepatic bile duct tumors are uncommon, with the majority being adenocarcinomas. Primary neuroendocrine tumors of the extrahepatic bile ducts are extremely rare. Herein, we report a case of the extrahepatic biliary duct primary well-differentiated neuroendocrine carcinoma in a 45-year-old woman.
