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Öğe Association of age-related macular degeneration with age-related hearing loss(CAMBRIDGE UNIV PRESS, 2011) Bozkurt, M. K.; Ozturk, B. T.; Kerimoglu, H.; Ersan, I.; Arbag, H.; Bozkurt, B.Objective: To assess the association between age-related macular degeneration and age-related hearing loss in Turkish subjects aged 50 years or older. Study design and setting: Prospective, case-control study within a tertiary university hospital. Subjects and methods: Fifty subjects with age-related macular degeneration and 43 healthy subjects underwent ophthalmological and otolaryngological examination. Statistical analyses were conducted for the poorer eye and ear, comparing age-related hearing loss and pure tone average in the macular degeneration group versus controls. Results: Median pure tone average was significantly poorer in the macular degeneration group (35 dBHL) compared with controls (23 dBHL). In the macular degeneration group, hearing loss was significantly greater in dry type (43 dBHL) than wet type (32 dBHL) cases. There was a significant difference between the prevalence of varying degrees of hearing loss in the macular degeneration versus control groups, being respectively: mild, 50 and 35 per cent; moderate, 20 and 5 per cent; and severe, 6 and 0 per cent. There was a weak, but significant correlation between each patient's visual acuity and pure tone average results (r(s) = -0.37, p < 0.001). Conclusion: Age-related hearing loss is more common in patients with age-related macular degeneration. Such patients should be questioned regarding hearing difficulty, and referred to an otolaryngologist if appropriate.Öğe Association of polymorphisms in APOE, p53, and p21 with primary open-angle glaucoma in Turkish patients(MOLECULAR VISION, 2009) Saglar, E.; Yucel, D.; Bozkurt, B.; Ozgul, R. K.; Irkec, M.; Ogus, A.Purpose: To investigate the association between Apolipoprotein E (APOE), tumor suppressor protein p53 (p53), and cyclin-dependent kinase inhibitor 1A (p21) genes and primary open-angle glaucoma (POAG) in a cohort of Turkish subjects. Methods: Seventy-five POAG patients (49 women, 26 men) and 119 healthy subjects (67 women, 52 men) were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Allele and genotype frequencies between healthy subjects and glaucoma patients were compared by the chi(2) test, and intraocular pressure (IOP), cup/disc ratio (C/D) and visual field indices (MD and PSD) were compared among different APOE, p53, and p21 genotypes in POAG group. A p value <0.05 was considered as statistically significant. Results: The mean ages were 63.8 +/- 9.5 and 61.8 +/- 10.2 years in POAG and control groups, respectively (p=0.18). There were no significant differences in the distribution of APOE, p53, and p21 genotypes between the healthy subjects and POAG patients (p=0.38, p=0.12, and p=0.2, respectively). There were no significant differences in maximum IOP, MD, and PSD values among different groups of p53 and p21 genotypes (p>0.05). POAG subjects with the epsilon 2 epsilon 3 genotype had a worse PSD value (median=2.2) than those with the epsilon 3 epsilon 4 genotype (median=1.77; p=0.01) and POAG subjects with the epsilon 3 epsilon 3 genotype had worse MD and PSD values (median=-7.4 and 3.4, respectively) than those with the epsilon 3 epsilon 4 genotype (median=-4.1 and 1.77, respectively; p=0.034 and 0.028, respectively). Conclusions: Our study found no link between polymorphisms in APOE, p53, and p21 genes and POAG in Turkish patients, although a larger sample is required to elucidate the role of these polymorphisms in the pathogenesis and course of glaucoma.Öğe Corneal crosslinking treatment for keratoconus in children with vernal keratoconjunctivitis(WILEY, 2017) Bozkurt, B.; Mesen, A.; Dilek, R.; Okudan, S.[Abstract not Available]Öğe Effect of Altered Eating Habits and Periods During Ramadan Fasting on Intraocular Pressure, Tear Secretion, Corneal and Anterior Chamber Parameters(NATURE PUBLISHING GROUP, 2010) Kerimoglu, H.; Öztürk, B.; Gündüz, K.; Bozkurt, B.; Kamış, U.; Okka, M.Purpose To determine whether altered eating habits and periods, especially the pre-dawn meal, during Ramadan fasting have any significant effect on intraocular pressure (IOP), tear secretion, corneal and anterior chamber parameters. Methods IOP, basal tear secretion (BTS), reflex tear secretion (RTS), and Pentacam measurements of 31 healthy volunteers were performed at 0800 and 1600 hours during Ramadan fasting and 1 month later during non-fasting period. Results Comparison of measurements between fasting and non-fasting periods at 0800 hours revealed significantly higher values for IOP (P = 0.005), RTS (P = 0.006), and BTS (P = 0.014) during fasting. Conversely at 1600 hours, IOP = was significantly lower during fasting (P = 0.013) and no statistically significant difference was noted for RTS and BTS. IOP showed a diurnal variation of 2.45 mmHg (P < 0.001) and BTS showed a 3.06 mm decrease (P = 0.04) during the fasting period. No significant differences could be found in the corneal and anterior chamber parameters during fasting and non-fasting periods. Conclusions Our results revealed that fluid loading at the pre-dawn meal during Ramadan fasting might increase the IOP = and tear secretion in the early morning period and these values decrease remarkably at the end of 12 h of fasting due to dehydration.Öğe Effect of radiation on cytokines, MMP-1 and type I collagen mRNA expressions in human gingival fibroblasts.(AMER SOC CLINICAL ONCOLOGY, 2011) Yavas, G.; Yavas, C.; Bozkurt, B.; Ata, O.; Hakki, S.[Abstract not Available]Öğe Exhaled nitric oxide levels in children with vernal keratoconjunctivitis(WILEY-BLACKWELL, 2016) Bozkurt, B.; Artac, H.; Ozdemir, H.; Dikener, H.[Abstract not Available]Öğe Follow-up of lupus choroidopathy with optical coherence tomography(SAGE PUBLICATIONS LTD, 2011) Ozturk, B. T.; Bozkurt, B.; Karademir, Z.; Kerimoglu, H.A 36-year-old female followed with the diagnosis of systemic lupus erythematosus complained of bilateral visual loss. Ophthalmological examination revealed disc edema with irregular borders, edematous and pale retina with widespread cotton wool spots, intraretinal hemorrhages and serous retinal detachment in both eyes. Optical coherence tomography (OCT) scans showed intraretinal and subretinal fluid creating cystic cavities with central subfield macular thickness values of 994 and 912 mu m in the right and left eye, respectively. The follow-up scans after the treatment with systemic steroid, acetylsalicylic acid and cyclosporine documented resolution of this fluid accumulation and a decrease in macular thickness measurements. These clearly demonstrated that OCT, which is a fast, objective and non-invasive technology, may be an adjunctive imaging tool for the diagnosis and follow-up of lupus choroidopathy. Lupus (2011) 20, 1076-1078.Öğe IgG4 related disease and ligneous conjunctivitis in a girl: A coexistence or a relationship(WILEY, 2019) Emiroglu, M.; Bozkurt, B.; Emiroglu, H. H.[Abstract not Available]Öğe In Vivo Confocal Microscopic Evaluation of the Inflammatory Response in Non-Epithelial Herpes Simplex Keratitis(Informa Healthcare, 2012) Mocan, M. C.; Irkec, M.; Mikropoulos, D. G.; Bozkurt, B.; Orhan, M.; Konstas, A. G. P.Purpose: To investigate the characteristics of the inflammatory response detected in corneas with active non-epithelial herpes simplex virus (HSV) keratitis. Materials and methods: The study was designed as a cross-sectional study undertaken at a university setting. Twenty-one eyes of 21 patients with a mean age of 40.1 +/- 13.0 years (range: 18-70 years) and whose corneal findings were compatible with active HSV keratitis were included. All patients were evaluated with in vivo confocal microscopy (Confoscan 3, Nidek). Fifty healthy, age-matched subjects served as controls. The features and extent of corneal inflammation, degree of involvement of subbasal nerve plexus and endothelial cell density were evaluated. Results: Seven eyes (33.3%) demonstrated stromal keratitis, six (28.6%) endotheliitis and eight (38.1%) presented with keratouveitis. Intraepithelial inflammatory cell infiltration, consisting of dendritic and small round cells, was observed in 11 eyes (52.4%). Stromal involvement was detected in 95.2% of eyes in the form of focal and diffuse cellular infiltrates; of these, anterior, posterior and pan stromal infiltration was observed in 85.7, 71.4 and 47.6% of cases, respectively. No particular keratic precipitate morphology was found to be diagnostic for HSV keratitis. The mean endothelial cell density of eyes with HSV keratitis (2437 +/- 599 cells/mm(2)) was significantly lower (-18.8%) than that of controls (3003 +/- 250 cells/mm(2)); (p < 0.001). The mean subbasal nerve density of patients with HSV keratitis (474.5 +/- 227.8 mu m/frame) was significantly lower than that of controls (1589.6 +/- 499.0 mu m/frame) (p < 0.001). Conclusions: Non-epithelial HSV keratitis related inflammatory response is characterized by cellular infiltration of all corneal layers, attenuation of the subbasal nerve plexus and endothelial cell loss.Öğe K-ras oncogene mutation in pterygium(NATURE PUBLISHING GROUP, 2017) Ozturk, B. T.; Yildirim, M. S.; Zamani, A.; Bozkurt, B.Purpose Pterygium is claimed to be a benign proliferation triggered by prolonged exposure to ultraviolet radiation. The frequency of K-ras oncogene mutation, which is among the initial mutations in tumorigenesis, is evaluated in this study. Patients and methods In this prospective randomized clinical, trial pterygium tissues and normal conjunctiva tissue specimens are obtained from the superotemporal quadrant of patients who underwent primary pterygium excision with autograft transplantation. DNA extraction from tissues was performed using the QIAamp DNA FFPE tissue kit. A PCR reaction was performed to amplify sequences containing codons 12, 13, and 61 of the K-ras gene in DNA. These PCR products then underwent the ` pyrosequencing' procedure for mutations at these codons. Results Pterygium and normal conjunctival tissue samples of 25 patients (10 females, 15 males) were evaluated in the study. The mean age of the patients was 54.54 +/- 13.13 years. Genetic analysis revealed no K-ras mutations in normal conjunctival tissues, whereas pterygium tissues of the same cases demonstrated mutation at codon 12 in one case and mutations at codon 61 in seven cases, which was statistically significant (P<0.05). The point missense mutations at codon 61 were glutamine to arginine (Glu61Arg CAA>CGA) in four cases and glutamine to leucine (Glu61Leu CAA>CTA) in three cases. Conclusion The significantly higher frequency of codon 61 mutation of the ras oncogene in primary and bilateral pterygium specimens compared with normal conjunctiva supports the tumoral origin of pterygium, and thus set the stage for research into a targeted therapy for pterygium with better outcomes than surgical excision.Öğe Serum allergen specific immunoglobulin E levels in patients with allergic conjunctivitis(SAGE PUBLICATIONS LTD, 2008) Kocabeyoglu, S.; Bozkurt, B.; Bilen, O.; Irkec, M.; Orhan, M.PURPOSE. To evaluate serum allergen specific immunoglobulin E (IgE) levels in patients with various types of allergic conjunctivitis. METHODS. Twenty-five patients with seasonal allergic conjunctivitis (SAC), 17 patients with perennial allergic conjunctivitis (PAC), and 10 patients with vernal conjunctivitis, (VC) were included in the study. Specific IgE levels to Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df), mixed grass pollens, and animal epithelia were measured using Pharmacia CAP system (Pharmacia Diagnostic AB, Uppsala, Sweden). RESULTS. The percentage of subjects with specific IgE against Dp and,Df was statistically higher in VC (30%) compared to PAC (5.9%) and SAC (0%) (p=0.03). Specific IgE against mixed grass pollens was found in 30% of VC and 40% of SAC, whereas: 10% of VC and 8% of SAC patients were found to be hypersensitive to animal epithelia. CONCLUSIONS. Allergic reaction against house dust mites and pollens was common in VC, whereas specific IgE against grass pollens was remarkable in SAC. IgE levels specific to various antigens might be measured by UNICAP system, which is a rapid and practical technology. (Eur J Ophthalmol 2008; 18: 675-9)Öğe Vernal keratoconjunctivitis-A rare but serious comorbidity of allergic rhinitis and eustachian tube dysfunction(ELSEVIER IRELAND LTD, 2010) Bozkurt, M. K.; Bozkurt, B.; Artac, H.; Arslan, N.; Reisli, I.Objective: To determine the prevalence of symptoms and signs of allergic rhinitis (AR) in children with vernal keratoconjunctivitis (VKC) and evaluate eustachian tube (ET) function using tympanometry. Methods: The patients underwent an otolaryngological examination and symptoms of rhinorrhoea, nasal obstruction, nasal itching and sneezing were evaluated for the diagnosis of AR. Tympanometry was performed by a middle ear analyzer (Impedance audiometer AZ 26, Interacoustics A/S, Assens, Denmark). Blood samples were collected for determination of peripheral blood eosinophil count (PBEC) and serum total immunoglobulin E (IgE). Allergen sensitivity was also determined by skin prick test. Results: The study included 26 males (96.3%) and 1 female (3.7%) with a mean age of 12.1 +/- 4.4 years. Eight out of 27 subjects (29.6%) had blood eosinophilia and 11 out of 27 subjects had elevated serum IgE (40.7%). A positive skin prick test was identified for at least one allergen in 40% of patients (10/25 subjects). Symptoms and signs of AR were found in 10 subjects (37%). Median serum IgE level in subjects with AR (262.5 kU/L)was higher than without AR(40.2 kU/L)(p = 0.08),whereas there were no differences in PBEC or eosinophilia percentage (p > 0.05). Mean middle ear pressures in the right and left ears were -66.4 daPa (range between -268 and 4 daPa) and -57.3 daPa (range between -308 and 0 daPa), respectively. The tympanometry results were abnormal in 5 subjects (18.5%) (3 type C and 2 type B tympanogram). Three out of 10 VKC patients with AR (30%) and 2 out of 17 VKC patients without AR (11.8%) had abnormal tympanograms (p = 0.33). Conclusion: AR is commonly associated with VKC and subjects with AR are almost three times more likely to have ET dysfunction than those without. Therefore, opthalmologists should refer VKC patients to otolaryngologists to delineate associated AR and ET dysfunction. Conversely, patients with OME and/or AR who have persistent allergic eye symptoms may well benefit from opthalmologic evaluation for seasonal allergic conjunctivitis and VKC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.Öğe Vitamin D serum levels in children with allergic rhinitis(WILEY-BLACKWELL, 2015) Artac, H.; Ozdemir, H.; Unlu, A.; Bozkurt, M. K.; Bozkurt, B.[Abstract not Available]Öğe Warburg Micro Syndrome in Two Children From a Highly Inbred Turkish Family(MEDECINE ET HYGIENE, 2012) Yıldırım, M. S.; Zamani, A. G.; Bozkurt, B.Warburg micro syndrome in two children from a highly inbred Turkish family: Warburg Micro syndrome (WMS) was first reported by Warburg in 1993. The cardinal features are microcephaly, microphthalmia, congenital cataract and intellectual disability. We report on two children from a highly inbred family with microcephaly, congenital cataract, optic atrophy, hypotonia and severe psychomotor retardation. This phenotype is similar to other reported rare entities and especially to the family reported by Warburg. Four other children in the same family may also have been affected. In this report, the symptoms and features of our cases are compared with the Warburg Micro syndrome patients in literature.
