In Vivo Confocal Microscopic Evaluation of the Inflammatory Response in Non-Epithelial Herpes Simplex Keratitis
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the characteristics of the inflammatory response detected in corneas with active non-epithelial herpes simplex virus (HSV) keratitis. Materials and methods: The study was designed as a cross-sectional study undertaken at a university setting. Twenty-one eyes of 21 patients with a mean age of 40.1 +/- 13.0 years (range: 18-70 years) and whose corneal findings were compatible with active HSV keratitis were included. All patients were evaluated with in vivo confocal microscopy (Confoscan 3, Nidek). Fifty healthy, age-matched subjects served as controls. The features and extent of corneal inflammation, degree of involvement of subbasal nerve plexus and endothelial cell density were evaluated. Results: Seven eyes (33.3%) demonstrated stromal keratitis, six (28.6%) endotheliitis and eight (38.1%) presented with keratouveitis. Intraepithelial inflammatory cell infiltration, consisting of dendritic and small round cells, was observed in 11 eyes (52.4%). Stromal involvement was detected in 95.2% of eyes in the form of focal and diffuse cellular infiltrates; of these, anterior, posterior and pan stromal infiltration was observed in 85.7, 71.4 and 47.6% of cases, respectively. No particular keratic precipitate morphology was found to be diagnostic for HSV keratitis. The mean endothelial cell density of eyes with HSV keratitis (2437 +/- 599 cells/mm(2)) was significantly lower (-18.8%) than that of controls (3003 +/- 250 cells/mm(2)); (p < 0.001). The mean subbasal nerve density of patients with HSV keratitis (474.5 +/- 227.8 mu m/frame) was significantly lower than that of controls (1589.6 +/- 499.0 mu m/frame) (p < 0.001). Conclusions: Non-epithelial HSV keratitis related inflammatory response is characterized by cellular infiltration of all corneal layers, attenuation of the subbasal nerve plexus and endothelial cell loss.
Açıklama
Anahtar Kelimeler
Herpetic keratitis, Inflammation, In vivo confocal microscopy
Kaynak
Current Eye Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
37
Sayı
12
Künye
Mocan, M. C., Irkec, M., Mikropoulos, D. G., Bozkurt, B., Orhan, M., Konstas, A. G. P., (2012). In Vivo Confocal Microscopic Evaluation of the Inflammatory Response in Non-Epithelial Herpes Simplex Keratitis. Informa Healthcare, 37(12), 1099-1106.
DOI: 10.3109/02713683.2012.707270
