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    Simultaneous occurrence of chronic myelogenous leukemia and non-Hodgkin lymphoma at diagnosis
    (ELSEVIER SCIENCE INC, 1999) Acar, Hasan; Ecirli, Şamil; Gündoğan, Fahreddin; Bulay, Orhan; Acar, Aynur
    We describe a case with the simultaneous occurrence of chronic myelogenous leukemia (CML) and non-Hodgkin lymphoma (NHL). Peripheral blood (PB) and bone marrow (BM) smears showed typical CML features. Lymph node biopsy exhibited a large-cell NHL. The Philadelphia chromosome or ifs molecular counterpart, the BCR-ABL gene fusion, by detecting with dual color-(DC) fluorescence in situ hybridization (FISH) was detected reliably both in metaphase spreads from BM and in interphase nuclei from BM and follow-up PB cells, but was not detected in the lymph node cells. Clinical features and laboratory findings show this case having a coexistence of CML and NHL. (C) Elsevier Science Inc., 1998.