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Öğe Dermoid cyst presenting with tachyarrhythmia: a case report(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2013) Oncel, Murat; Calik, Mustafa; Sunam, Guven SadiIn this article, we report a 45-year-old female patient who was admitted with the complaints of cough, dyspnea and palpitation and referred to our clinic from Cardiology Outpatient Clinic due to tachyarrhythmia with a preliminary diagnosis of mediastinal mass. Thoracic computed tomography (CT) showed a smooth, lobulated contour and locally calcified cystic mass with a size of 7x6 cm in the right-sided middle mediastinum showing air-fluid level. The thorax was explorated from the fifth intercostal space with a right posterolateral thoracotomy incision. Exploration revealed a mediastinal mass originating from vena cava superior at the upper part and reaching the lower lobe. The mass was excised. The result of the histopathological examination was reported as a dermoid cyst containing hair, cartilage and sebaceous glands. We present this case as cardiac arrhythmia is a rare sign of mediastinal cysts.Öğe The effect of costal cartilage resection on the chest watt development: a morphornetric evaluation(OXFORD UNIV PRESS INC, 2007) Calik, Mustafa; Aribas, Olgun Kadir; Kanat, FikretObjective: In repair of thoracic wall deformities, there is a debate in the literature regarding the optimal age and the type and number of costal cartilage resections. We evaluated the effect of costal. cartilage resections on the chest wall development in young rabbits. Methods: Fifty apparently healthy, 6 weeks of age, mate New Zealand white rabbits were evaluated in five groups, each including 10 subjects. Group I served as control for the observation of normal thoracic development. Rabbits in group 2 underwent partial and rabbits in group 3 underwent total resections of the right third and fourth costal cartilages; those in group 4 underwent partial and rabbits in group 5 underwent total resections of the right third to sixth costal, cartilages. Anteroposterior, horizontal and vertical diameters of the chest were measured before operation and repeated at 24 weeks of age. Results: Upper and lower anteroposterior diameters of the thoracic wall and horizontal diameters of the left hemithorax differed significantly among groups (p = 0.011, p = 0.004, and p = 0.002, respectively). Upper anteroposterior diameter was 49 mm in group 1 and 44 mm in group 3 (p = 0.009). Lower anteroposterior diameter in group 5 (66 mm) was significantly less than that in group 1 (70 mm) (p = 0.039) and there was also a statistically significant difference between group 4 (71 mm) and group 5 (66 mm) (p = 0.002). Horizontal diameters of the left hemithorax in group 3 (32 mm; p = 0.005) and 5 (32 mm; p = 0.008) were significantly different when compared to group 1 (26 mm). Growth in right hemithorax was statistically less than that in left side in all operated groups except in group 2. Conclusions: Thoracic resections in young rabbits have demonstrated that the costal cartilage resection is not an innocent procedure as it severely affects the chest watt development especially in anteroposterior direction and the thoracic growth is markedly retarded when growth centers of the ribs are not preserved and/or four or more ribs are resected. (C) 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.Öğe The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis(CHURCHILL LIVINGSTONE, 2013) Yavas, Guler; Calik, Mustafa; Calik, Goknil; Yavas, Cagdas; Ata, Ozlem; Esme, HidirThe lung is one of the most sensitive organs to ionizing radiation, and damage to normal lung tissue remains a major dose limiting factor for patients receiving radiation to the thorax. Radiation induced lung injury (RILI) which is also named as "radiation pneumonpathy" is a continuous process and regarded as the result of an abnormal healing response. It has been shown that transforming growth factor beta-1 (TGF-beta 1) plays an integral role in the radiation induced lung fibrosis formation by promoting the chemoattraction of fibroblasts and their conversion to myofibroblasts. Halofuginone is a, low molecular weight plant derived alkaloid, isolated from the Dichroa febnfuga plant that exhibits antifibrotic activity and inhibition of type I collagen synthesis. Halofuginone has been shown to protect against radiation induced soft tissue fibrosis by virtue of inhibiting various members of TFG-beta signaling pathway. By the light of these findings, we hypothesize that Halofuginone may be able to ameliorate the radiation induced lung fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.Öğe The effect of morphine delta receptor activity on ischemic postconditioning in lung ischemia reperfusion injury(TURKISH RESPIRATORY SOC, 2018) Duzgun, Nuri; Esme, Hidir; Kilinc, Ibrahim; Calik, MustafaOBJECTIVE: In the context of the physiopathology of lung damage due to ischemia and reperfusion injury, we aimed to reveal the effects of the addition of morphine sulfate to ischemic postconditioning (PC) protocol. METHODS: In the present study, 48 Wistar albino female rats were employed. Group 1 was accepted as the Sham group that underwent thoracotomy through the fifth left intercostal space. Ischemia-reperfusion (IR) group: Thoracotomy and IR period. IRPC group: thoracotomy, IR period and ischemic PC. In IRPC3 and IRPC30 groups, in addition to ischemic PC different doses of morphine sulfate (3 mu mol and 30 mu mol) was administered. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-10 levels were measured in the biochemical assessment of the lung tissue samples obtained. RESULTS: TNF-alpha and IL-1 (pro-inflammatory cytokines) have lower values, and IL-10 (anti-inflammatory cytokine) have higher values both in the groups which have been subject to PC and morphine. TNF-alpha and IL-1 levels in lung tissue were statistically significant between the IRPC3 group and the IR and IRPC groups. In addition, IL-10 level in lung tissue was statistically significant between the IRPC3 group and the IRPC group. CONCLUSION: In the present study conducted with experimental animals where morphine was also injected beside ischemic PC protocols, statistically significant differences were determined in the lung tissue analyses when we compared pro-inflammatory and anti-inflammatory cytokine values. We firmly believe that adding morphine to the lung transplantation protocols and PC will decrease IR damage.Öğe Rib fractures: Could we accelerate the healing?(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2015) Calik, Mustafa; Calik, Saniye Goknil; Aribas, Olgun Kadir; Baltaci, Abdulkerim Kasim[Abstract not Available]
