The effect of morphine delta receptor activity on ischemic postconditioning in lung ischemia reperfusion injury
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH RESPIRATORY SOC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: In the context of the physiopathology of lung damage due to ischemia and reperfusion injury, we aimed to reveal the effects of the addition of morphine sulfate to ischemic postconditioning (PC) protocol. METHODS: In the present study, 48 Wistar albino female rats were employed. Group 1 was accepted as the Sham group that underwent thoracotomy through the fifth left intercostal space. Ischemia-reperfusion (IR) group: Thoracotomy and IR period. IRPC group: thoracotomy, IR period and ischemic PC. In IRPC3 and IRPC30 groups, in addition to ischemic PC different doses of morphine sulfate (3 mu mol and 30 mu mol) was administered. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-10 levels were measured in the biochemical assessment of the lung tissue samples obtained. RESULTS: TNF-alpha and IL-1 (pro-inflammatory cytokines) have lower values, and IL-10 (anti-inflammatory cytokine) have higher values both in the groups which have been subject to PC and morphine. TNF-alpha and IL-1 levels in lung tissue were statistically significant between the IRPC3 group and the IR and IRPC groups. In addition, IL-10 level in lung tissue was statistically significant between the IRPC3 group and the IRPC group. CONCLUSION: In the present study conducted with experimental animals where morphine was also injected beside ischemic PC protocols, statistically significant differences were determined in the lung tissue analyses when we compared pro-inflammatory and anti-inflammatory cytokine values. We firmly believe that adding morphine to the lung transplantation protocols and PC will decrease IR damage.
Açıklama
Anahtar Kelimeler
Ischemia and reperfusion injury, ischemic postconditioning, morphine sulfate
Kaynak
EURASIAN JOURNAL OF PULMONOLOGY
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
20
Sayı
2
