The effect of morphine delta receptor activity on ischemic postconditioning in lung ischemia reperfusion injury

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dc.contributor.authorDuzgun, Nuri
dc.contributor.authorEsme, Hidir
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorCalik, Mustafa
dc.date.accessioned2020-03-26T19:56:03Z
dc.date.available2020-03-26T19:56:03Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: In the context of the physiopathology of lung damage due to ischemia and reperfusion injury, we aimed to reveal the effects of the addition of morphine sulfate to ischemic postconditioning (PC) protocol. METHODS: In the present study, 48 Wistar albino female rats were employed. Group 1 was accepted as the Sham group that underwent thoracotomy through the fifth left intercostal space. Ischemia-reperfusion (IR) group: Thoracotomy and IR period. IRPC group: thoracotomy, IR period and ischemic PC. In IRPC3 and IRPC30 groups, in addition to ischemic PC different doses of morphine sulfate (3 mu mol and 30 mu mol) was administered. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-10 levels were measured in the biochemical assessment of the lung tissue samples obtained. RESULTS: TNF-alpha and IL-1 (pro-inflammatory cytokines) have lower values, and IL-10 (anti-inflammatory cytokine) have higher values both in the groups which have been subject to PC and morphine. TNF-alpha and IL-1 levels in lung tissue were statistically significant between the IRPC3 group and the IR and IRPC groups. In addition, IL-10 level in lung tissue was statistically significant between the IRPC3 group and the IRPC group. CONCLUSION: In the present study conducted with experimental animals where morphine was also injected beside ischemic PC protocols, statistically significant differences were determined in the lung tissue analyses when we compared pro-inflammatory and anti-inflammatory cytokine values. We firmly believe that adding morphine to the lung transplantation protocols and PC will decrease IR damage.en_US
dc.identifier.doi10.4103/ejop.ejop_13_18en_US
dc.identifier.endpage64en_US
dc.identifier.issn2148-3620en_US
dc.identifier.issn2148-5402en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://dx.doi.org/10.4103/ejop.ejop_13_18
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37005
dc.identifier.volume20en_US
dc.identifier.wosWOS:000443872700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTURKISH RESPIRATORY SOCen_US
dc.relation.ispartofEURASIAN JOURNAL OF PULMONOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia and reperfusion injuryen_US
dc.subjectischemic postconditioningen_US
dc.subjectmorphine sulfateen_US
dc.titleThe effect of morphine delta receptor activity on ischemic postconditioning in lung ischemia reperfusion injuryen_US
dc.typeArticleen_US

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