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Evaluation of Aflatoxin B1 Binding Capacity with Mix Toxin Binder using Central Composite Design
(Selçuk Üniversitesi, 2024 Nisan) Yalçın, Nihayet Fadime; Cantekin, Cafer; Uğuz, Halis; Alataş, Mustafa Selçuk; Sherazi, Syed Tufail Hussain; Topkafa, Mustafa
Aflatoxin B1 (afl B1) binding capacity of a mixed toxin binder used in poultry nutrition was determined using the central composite design technique. Experimental conditions such as pH, temperature, and incubation time for the determination of the binding capacity of the mixed binder were optimized for Central Composite Design. The impact of these three independent variables on the percentage binding of aflatoxin B1 was evaluated at different five levels (-1.68, -1, 0, 1, 1.68). The optimum experimental conditions were 5.8 pH, 42°C temperature, and 94.11 minutes incubation time, respectively, using a quadratic model and desirability function. A significant effect of each independent variable was observed on the percentage binding efficiency of aflatoxin B1. Under optimum experimental conditions, aflatoxin B1 binding capacity with mix toxin binder was found to be 97%. The results of the present study indicated that the mixed binder is very suitable for binding aflatoxin B1 and the central composite design can be used effectively in determining the optimized parameters for improving toxin binding capacity of aflatoxin B1.