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Öğe Adjuvant Carboplatin and Paclitaxel after Concurrent Cisplatin and Radiation Therapy in Patients with Locally Advanced Cervical Cancer(ELSEVIER SCIENCE INC, 2018) Yavas, G.; Yavas, C.; Sen, E.; Oner, I.; Celik, C.; Ata, O.[Abstract not Available]Öğe Anti-Mullerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer(INFORMA HEALTHCARE, 2015) Dogan, N. U.; Kerimoglu, O. S.; Karabagli, P.; Pekin, A.; Yilmaz, S. A.; Incesu, F.; Celik, C.Our aim was to evaluate serum levels of anti-Mullerian hormone (AMH) and also immunohistochemical (IHC) staining properties of AMH receptor type II (AMHRII) in patients with endometrial cancer (EC) and a control group. Preoperatively, serum levels of AMH were assessed and AMHRII expression was evaluated by immunohistochemistry in a benign and malignant group. AMH serum levels of the control group and EC patients were comparable. For EC patients, there was no difference with respect to the AMH levels and tumour stage; grade; histological type; deep myometrial invasion; lymphovascular space invasion or lymph node involvement. However, AMH levels in patients with extrauterine involvement were higher than patients with disease confined to the uterus. EC samples were more likely to be stained positive for AMHRII than benign lesions. Also, as the stage of the lesion worsens, the rate of IHC staining of AMHRII decreases. In conclusion, AMHRII is expressed in normal endometrial cells as well as endometrial cancer cells. AMH levels increase in EC, with extrauterine involvement at least in locally advanced disease. Also AMH expression decreases as the disease is staged-up.Öğe APPENDICEAL MUCINOUS NEOPLASM MIMICKING OVARIAN CANCER : TWO CASE REPORTS(LIPPINCOTT WILLIAMS & WILKINS, 2017) Sahin, G.; Ugurluoglu, C.; Akar, S.; Gul, A.; Celik, C.; Yilmaz, S. A.[Abstract not Available]Öğe Assessment of body composition with bioelectrical impedance analysis in pregnant women with hyperemesis gravidarum before and after treatment(TAYLOR & FRANCIS INC, 2015) Pekin, A. Tazegul; Yilmaz, S. A.; Kerimoglu, O. Secilmis; Celik, G.; Dogan, N. U.; Beyhekim, H.; Celik, C.More than half of pregnant women suffer from nausea and vomiting, in 0.5-1% of the pregnant women, if nausea and vomiting are severe and persistent, condition can progress to hyperemesis. We evaluated the fluid volume parameters in pregnant women with hyperemesis gravidarum, before and after treatment using the bioelectrical impedance vectors. A total of 70 pregnant women who had weight loss exceeding 5% of pre-pregnancy body weight were recruited for the study in the first trimester. The measurement of multi-frequency bioelectrical impedance analysis parameters was performed on the day of hospitalisation before any treatment and after treatment at 24 h and 72 h with the same procedure. Total body water, extracellular water, intracellular water, and fat-free mass index increased after treatment at 24 h (P < 0.01). Also, the mean pregnancy-unique quantification of emesis and nausea score was significantly lower after treatment (11.3 +/- 2.1 at enrolment, 5.1 +/- 1.4 at 24 h and 4.3 +/- 1.1 at 72 h) (P < 0.01), which correlated with the patients' clinical improvement and changes in hydration. In pregnant women with moderate-to-severe hyperemesis gravidarum, significant body composition changes occur and fluid replacement therapy performed during a short period of time, such as 24 h, provides improvement in body composition.Öğe ASSOCIATION OF ANTI-MULLERIAN HORMON (AMH) SERUM LEVELS AND ENDOMETRIAL AMH RECEPTOR II EXPRESSION IN PATIENTS WITH ENDOMETRIAL CANCER(LIPPINCOTT WILLIAMS & WILKINS, 2013) Celik, C.; Dogan, N. U.; Karabagli, P.; Kerimoglu, O. S.; Tazegul, A.; Incesu, F.[Abstract not Available]Öğe A CASE REPORT: A RETROPERITONEAL AGGRESSIVE FIBROMATOSIS (AF)(BMJ PUBLISHING GROUP, 2018) Gul, A.; Ugurluoglu, C.; Akar, S.; Sahin, G.; Bayramoglu, D.; Celik, C.[Abstract not Available]Öğe A comparison of liquid-based cytology with conventional cytology(ELSEVIER IRELAND LTD, 2008) Celik, C.; Gezginc, K.; Toy, H.; Findik, S.; Yilmaz, O.Objective: To evaluate the 2 methods of cytologic screening to detect abnormalities of the cervical epithelium. Methods: This study with 3 groups of women was performed at Selcuk University Meram Medical School between January 2004 and March 2006. In one group (paired sample for specimen collection) women were screened with conventional cytology; in another group (paired sample for specimen collection) they were screened with liquid-based cytology; and in the third group (split sample for specimen collection) they were screened by both methods. Results: The rate of unsatisfactory results was lower in the liquid-based than in the conventional cytology group (6.1% vs. 2.6%; P < 0.05). More smears containing atypical squamous cells of undetermined significance were detected by the liquid-based method, but the difference was not statistically significant. Also, no statistically significant differences between liquid-based and conventional cytology were observed in the detection of other epithelial abnormalities (P > 0.05). Conclusion: The liquid-based and conventional cytology methods were found to be equivalent in the detection of cervical epithelial abnormalities. (c) 2007 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe COMPARISON OF THE EFFECT OF HUMAN PAPILLOMA VIRUS (HPV) SCREENING ON PATIENT ANXIETY WITH CONVENTIONAL METHODS(LIPPINCOTT WILLIAMS & WILKINS, 2017) Ilhan, T. T.; Sahin, G.; Akar, S.; Gul, A.; Celik, C.; Ucar, M. G.[Abstract not Available]Öğe Does omentum density have prognostic importance for endometrial cancer? Preliminary result(LIPPINCOTT WILLIAMS & WILKINS, 2016) Ilhan, T. T.; Gul, A.; Celik, C.[Abstract not Available]Öğe Effect of drainage on postoperative pain after laparoscopic ovarian cystectomy(INFORMA HEALTHCARE, 2015) Kerimoglu, O. S.; Yilmaz, S. A.; Pekin, A.; Incesu, F.; Dogan, N. U.; Ilhan, T. T.; Celik, C.The aim of this prospective study was to investigate the effect of drainage on postoperative shoulder and abdominal pain after uncomplicated laparoscopic ovarian cystectomy (LOC). Allocation to drain or not to drain was non-randomised. There were 55 patients with drainage and 56 patients without drainage. Postoperative shoulder and abdominal pain was assessed using a 10-point visual analogue scale. Postoperative hospital stay in the drainage group was longer than the non-drainage group (p = 0.040). Postoperative shoulder pain scores at 6 h and 24 h were similar between the drainage and non-drainage groups (p = 0.376 and p = 0.847, respectively). Postoperative abdominal pain was higher in the drainage group at 6 h (p = 0.009), but was similar at 24 h (p = 0.097) between the groups. These data suggest that for LOC, drainage may not be useful to prevent postoperative shoulder pain and also increases postoperative abdominal pain and length of hospital stay.Öğe The effect of gynecologic cancer on patient's depression and anxiety: prospective study(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015) Ilhan, T. T.; Kebapcilar, A. K.; Ilhan, T. I.; Cakir, T. C.; Yilmaz, S. A.; Celik, C.; Bakbak, B. B. B.[Abstract not Available]Öğe The effect of radical gynecologic surgery on urinary incontinence(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015) Ilhan, T. T.; Kebapcilar, A. K.; Bakbak, B. B. B.; Ilhan, T. I.; Yilmaz, S. A.; Cakir, T. C.; Celik, C.[Abstract not Available]Öğe The effects of hormone replacement therapy on the myocardial velocities and myocardial performance index(OXFORD UNIV PRESS, 2007) Duzenli, M. A.; Ozdemir, K.; Sokmen, A.; Soylu, A.; Gezginc, K.; Celik, C.; Tokac, M.[Abstract not Available]Öğe The Effects of Intrathecal Morphine on Patient-controlled Analgesia, Morphine Consumption, Postoperative Pain and Satisfaction Scores in Patients Undergoing Gynaecological Oncological Surgery(SAGE PUBLICATIONS LTD, 2012) Kara, I.; Apiligullari, S.; Oc, B.; Celik, J. B.; Duman, A.; Celik, C.; Dogan, N. U.OBJECTIVE: Gynaecological oncological surgery (GOS) includes a wide variety of surgical procedures and postoperative pain is a major concern. This study compared the impact of intrathecal morphine (ITM) plus patient-controlled analgesia (PCA) with PCA alone on morphine consumption, pain relief and patient satisfaction after GOS. METHODS: Sixty women undergoing GOS under general anaesthesia were randomized to receive either 0.3 mg ITM or placebo. On arrival at the postanaesthesia care unit each patient received a morphine PCA pump. The three primary outcome measures were pain, patient satisfaction scores evaluated using a 100-mm visual analogue scale and cumulative PCA morphine consumption. RESULTS: No significant differences were observed in the demographic data. Cumulative PCA morphine consumption was significantly lower in the ITM group compared with the control group. Fatigue scores were lower in the ITM group compared with the control group but did not reach statistical significance. Pain, sedation and patient satisfaction scores, and the rate of side-effects were similar for the two groups. CONCLUSIONS: Administering ITM in GOS could improve postoperative analgesia and reduce morphine consumption without serious side-effects.Öğe EPIDEMIOLOGICAL ASSESSMENT OF GYNECOLOGIC ONCOLOGY CASES(LIPPINCOTT WILLIAMS & WILKINS, 2015) Asghari, N.; Kara, F.; Ilhan, T.; Celik, C.[Abstract not Available]Öğe EPITHELIOID TROPHOBLASTIC TUMOR IN YOUNG WOMAN(LIPPINCOTT WILLIAMS & WILKINS, 2015) Ilhan, T.; Kebapcilar, A.; Kerimoglu, O.; Ilhan, T.; Cakir, T.; Celik, C.[Abstract not Available]Öğe EVALUATION OF THE EFFECT OF HUMAN PAPILLOMA VIRUS (HPV) POSITIVITY ON PATIENT ANXIETY(LIPPINCOTT WILLIAMS & WILKINS, 2017) Sahin, G.; Ilhan, T. T.; Akar, S.; Gul, A.; Celik, C.; Kerimoglu, O. Secilmis[Abstract not Available]Öğe EVALUATION OF THE EFFECT OF HUMAN PAPILLOMA VIRUS (HPV) POSITIVITY ON PATIENT ANXIETY -- 2(LIPPINCOTT WILLIAMS & WILKINS, 2017) Sahin, G.; Ilhan, T. T.; Akar, S.; Gul, A.; Celik, C.; Secilmis Kerimoglu, O.[Abstract not Available]Öğe The evaluation of the reliability and contribution of frozen section pathology to staging endometrioid adenocarcinomas(SPRINGER, 2013) Karabagli, P.; Yilmaz, B.; Celik, C.; Ugras, S.[Abstract not Available]Öğe Expression of cyclin A, cyclin E and p27 in normal, hyperplastic and frankly malignant endometrial samples(INFORMA HEALTHCARE, 2013) Gezginc, S. T.; Celik, C.; Dogan, N. U.; Toy, H.; Tazegul, A.; Colakoglu, M. C.Cellular growth is under the control of certain molecules such as cyclins and cyclin dependent kinases. Dysregulation of these proteins disrupt cell cycle and may trigger malignant transformation. Cyclins and kinase inhibitors also play essential roles in endometrial cellular proliferation. But the exact roles of these mediators in the disease process is not clear. We evaluated expression of cyclin A, cyclin E and p27 in normal, hyperplastic and malignant endometrial samples assuming different expression patterns in physiological and pathological processes. A total of 75 patients with histopathological diagnosis of normal proliferative, hyperplastic or malignant endometrial samples were evaluated with different cellular proliferation markers, cyclin A, cyclin E and p27. For cyclin E, endometrial cancer samples had higher rate of immunoreactivity than normal proliferative and hyperplastic endometrial samples. Staining properties for cyclin A were comparable for three groups. However, p27 immunoreactivity decreased progressively as lesions progress from proliferative benign endometrium to frank carcinoma. Further large-scale studies with clinical follow-up will reveal the exact role of cyclins on endometrial carcinogenesis.
